Well-differentiated liposarcoma causing non-islet cell tumor hypoglycemia

Non-islet cell tumor hypoglycemia (NICTH) is a paraneoplastic syndrome that causes severe hypoglycemia. The tumor involved produces high-molecular-weight insulin-like growth factor-II (IGF-II). NICTH can be caused by various benign and malignant tumors. However, NICTH due to liposarcoma (LPS) is rar...

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Bibliographic Details
Published in:International cancer conference journal Vol. 11; no. 3; pp. 210 - 214
Main Authors: Igarashi, Yosuke, Hirukawa, Hiroshi, Nakano, Tetsuya, Morimoto, Yuta, Fukuda, Shintaro, Tada, Tetsuya
Format: Journal Article
Language:English
Published: Singapore Springer Nature Singapore 01.07.2022
Springer Nature B.V
Subjects:
Abdomen
Antibodies
Autoimmune diseases
Case Report
Case reports
Cell differentiation
Conflicts of interest
Emergency medical care
Glucose
Hormones
Hypoglycemia
Insulin
Insulin-like growth factor I
Insulin-like growth factor II
Insulin-like growth factors
Laboratories
Lipopolysaccharides
Liposarcoma
Medicine
Medicine & Public Health
Mesentery
Molecular weight
Oncology
Paraneoplastic syndrome
Patients
Peptides
Small intestine
Surgery
Surgical Oncology
Tomography
Tumors
Unconsciousness
Vomiting
Non-islet cell tumor hypoglycemia
Well-differentiated liposarcoma
Hypoglycemia
IGF-II
ISSN:2192-3183, 2192-3183
Online Access:Get full text
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Summary:Non-islet cell tumor hypoglycemia (NICTH) is a paraneoplastic syndrome that causes severe hypoglycemia. The tumor involved produces high-molecular-weight insulin-like growth factor-II (IGF-II). NICTH can be caused by various benign and malignant tumors. However, NICTH due to liposarcoma (LPS) is rare. A 38-year-old man was brought to the hospital emergency department with complaints of vomiting and unconsciousness. His abdomen was distended, and a large tumor was palpable. He had severe hypoglycemia that required continuous glucose infusion. Radiological examination revealed a large 40-cm mass that filled the abdominal cavity, and LPS of the mesentery was suspected. Laboratory data showed low levels of insulin, C-peptide, and IGF-I concentrations. Subsequently, an LPS-induced NICTH was suspected. Complete resection of the tumor and the encased small intestine was performed. The pathological diagnosis was well-differentiated liposarcoma (WDLPS). The Western immunoblot showed that the high-molecular-weight IGF-II confirmed in the serum preoperatively, had almost disappeared postoperatively. Based on these findings, NICTH caused by a WDLPS was diagnosed. The postoperative course was uneventful. In the last 4 years since the primary operation, the patient had not experienced further hypoglycemia symptoms. Here, we report a case of NICTH caused by a large WDLPS. NICTH should be considered in patients with both severe hypoglycemia and large tumors. In these cases, appropriate treatment including semi-urgent surgery should be provided.
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ISSN:2192-3183
2192-3183
DOI:10.1007/s13691-022-00550-1