Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells

Cyclophilin A (CypA) is a peptidyl-prolyl isomerase that binds to the capsid protein (CA) of human immunodeficiency virus type 1 (HIV-1) and by doing so facilitates HIV-1 replication. Although CypA is incorporated into HIV-1 virions by virtue of CypA-Gag interactions that occur during virion assembl...

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Veröffentlicht in:	Journal of virology Jg. 79; H. 1; S. 176
Hauptverfasser:	Hatziioannou, Theodora, Perez-Caballero, David, Cowan, Simone, Bieniasz, Paul D
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2005
Schlagworte:	Animals Antiviral Restriction Factors Capsid - metabolism Capsid Proteins - genetics Capsid Proteins - metabolism Carrier Proteins - metabolism Cell Line Cyclophilin A - genetics Cyclophilin A - metabolism Cyclosporine - metabolism HeLa Cells HIV-1 - genetics HIV-1 - metabolism HIV-1 - pathogenicity Humans Jurkat Cells Mutation Peptidylprolyl Isomerase - genetics Peptidylprolyl Isomerase - metabolism Tripartite Motif Proteins Ubiquitin-Protein Ligases Virion - metabolism Virus Replication
ISSN:	0022-538X
Online-Zugang:	Weitere Angaben
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