Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial

Most patients with irritable bowel syndrome (IBS) are managed in primary care. When first-line therapies for IBS are ineffective, the UK National Institute for Health and Care Excellence guideline suggests considering low- dose tricyclic antidepressants as second-line treatment, but their effectiven...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	The Lancet (British edition) Ročník 402; číslo 10414; s. 1773 - 1785
Hlavní autoři:	Ford, Alexander C, Wright-Hughes, Alexandra, Alderson, Sarah L, Ow, Pei-Loo, Ridd, Matthew J, Foy, Robbie, Bianco, Gina, Bishop, Felicity L, Chaddock, Matthew, Cook, Heather, Cooper, Deborah, Fernandez, Catherine, Guthrie, Elspeth A, Hartley, Suzanne, Herbert, Amy, Howdon, Daniel, Muir, Delia P, Nath, Taposhi, Newman, Sonia, Smith, Thomas, Taylor, Christopher A, Teasdale, Emma J, Thornton, Ruth, Farrin, Amanda J, Everitt, Hazel A, Ford, Alexander C., Wright-Hughes, Alex, Alderson, Sarah L., Ridd, Matthew J., Barratt, Maggie, Bishop, Felicity L., Brindle, Richard, Brown, Sarah, Christodoulou, Aimee, Day, Florence, Dowse, Aaron, Durnell, Jill, Emmerson, Jake, Fellows, Alasdair, Guthrie, Elspeth A., Hindmarch, Damien, Malik, Aminah, Morris, Tom, Muir, Delia P., Longo, Roberta, Lopes Goncalves Graca, Sandra, Parker, Catriona, Taylor, Christopher A., Teasdale, Emma J., Tubeuf, Sandy, West, Amy, Williamson, Emma-Jane, Farrin, Amanda J., Everitt, Hazel A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 11.11.2023 Elsevier Limited
Témata:	Adverse events Amitriptyline Amitriptyline - adverse effects Antidepressants C-reactive protein Disease Double-Blind Method Double-blind studies Drug dosages Effectiveness England Female Health care Humans Informed consent Intestine Irritable bowel syndrome Irritable Bowel Syndrome - drug therapy Laxatives Male Middle Aged Pandemics Placebos Primary care Primary Health Care Quality of life Serology Technology assessment Titration Treatment Outcome Tricyclic antidepressants England United Kingdom > UK United States > US
ISSN:	0140-6736, 1474-547X, 1474-547X
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!