Resolution of Inflammation after Skeletal Muscle Ischemia–Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and Maresins

Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress. In addition to overabundance of pro-inflammatory stimuli, excessive and uncontrolled...

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Veröffentlicht in:Antioxidants Jg. 11; H. 6; S. 1213
Hauptverfasser: Barnig, Cindy, Lutzweiler, Gaetan, Giannini, Margherita, Lejay, Anne, Charles, Anne-Laure, Meyer, Alain, Geny, Bernard
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel MDPI AG 20.06.2022
MDPI
Schlagworte:
Antioxidants
Apoptosis
Chemokines
Cytokines
death
Dehydrogenases
Heparan sulfate
Homeostasis
Inflammation
Ischemia
Kidneys
Kinases
leukocytes
Leukocytes (polymorphonuclear)
lipid mediators
Lipid peroxidation
Lipids
lipoxin
Macrophages
Metabolism
Microorganisms
Mitochondria
Mitochondrial DNA
Multiple organ dysfunction syndrome
muscles
Musculoskeletal system
Neutrophils
Oxidative stress
Peptides
Permeability
Physiology
Polyunsaturated fatty acids
protectins and maresins
Proteins
Reperfusion
resolvins
Review
Signal transduction
Skeletal muscle
Therapeutic applications
therapeutics
Tumor necrosis factor-TNF
ISSN:2076-3921, 2076-3921
Online-Zugang:Volltext
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Zusammenfassung:Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress. In addition to overabundance of pro-inflammatory stimuli, excessive and uncontrolled inflammation can also result from defects in resolution signaling. Importantly, the resolution of inflammation is an active process also based on specific lipid mediators including lipoxins, resolvins and maresins that orchestrate the potential return to tissue homeostasis. Thus, lipid mediators have received growing attention since they dampen deleterious effects related to ischemia–reperfusion. For instance, the treatment of skeletal muscles with resolvins prior to ischemia decreases polymorphonuclear leukocyte (PMN) infiltration. Additionally, remote alterations in lungs or kidneys are reduced when enhancing lipid mediators’ functions. Accordingly, lipoxins prevented oxidative-stress-mediated tissue injuries, macrophage polarization was modified and in mice lacking DRV2 receptors, ischemia/reperfusion resulted in excessive leukocyte accumulation. In this review, we first aimed to describe the inflammatory response during ischemia and reperfusion in skeletal muscle and then discuss recent discoveries in resolution pathways. We focused on the role of specialized pro-resolving mediators (SPMs) derived from polyunsaturated fatty acids (PUFAs) and their potential therapeutic applications.
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ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11061213