Lipid profile is associated with the incidence of cognitive dysfunction in viral cirrhotic patients: A data-mining analysis

Aim:  Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision‐...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Hepatology research Ročník 43; číslo 4; s. 418 - 424
Hlavní autoři: Taniguchi, Eitaro, Kawaguchi, Takumi, Sakata, Masahiro, Itou, Minoru, Oriishi, Tetsuharu, Sata, Michio
Médium: Journal Article
Jazyk:angličtina
Vydáno: Melbourne, Australia Blackwell Publishing Asia 01.04.2013
Témata:
Algorithms
decision-tree algorithm
fatty acid
minimal hepatic encephalopathy
neuropsychiatric test
neurospsychiatric test
ISSN:1386-6346, 1872-034X
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Aim:  Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision‐tree algorithm. Methods:  In this study, 27 viral cirrhotic patients were enrolled. All subjects underwent neuropsychiatric tests; two or more abnormal results were defined as CD. A logistic regression model was used for multivariate stepwise analysis. A decision‐tree algorithm was constructed, and the categorical differences based on the decision‐tree model were analyzed by χ2‐tests. Results:  Multivariate stepwise analysis showed the levels of total bilirubin, triglycerides and free fatty acids (FFA) as independent bioparameters associated with the incidence of CD in cirrhotic patients. The decision‐tree algorithm showed that among patients with FFA of 514 mEq/L or more, 77.8% had CD. Meanwhile, among patients with FFA of less than 514 mEq/L and triglycerides of 106 mg/dL or more, 20.0% had CD. The sensitivity, specificity and accuracy for the incidence of CD using the lipid profile (FFA >514 mEq/L or triglycerides <106 mg/dL) were 85.7% (12/14), 61.5% (8/13) and 74.1% (20/27), respectively. Conclusion:  The levels of total bilirubin, FFA and triglycerides are independently associated with the incidence of CD in cirrhotic patients. In addition, a decision‐tree algorithm revealed that FFA of more than 514 mEq/L or triglycerides of less than 106 mg/dL is a profile associated with the incidence of CD. Thus, this lipid profile could be a possible screening bioparameter for CD in cirrhotic patients.
AbstractList Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision-tree algorithm.AIM  Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision-tree algorithm.  In this study, 27 viral cirrhotic patients were enrolled. All subjects underwent neuropsychiatric tests; two or more abnormal results were defined as CD. A logistic regression model was used for multivariate stepwise analysis. A decision-tree algorithm was constructed, and the categorical differences based on the decision-tree model were analyzed by χ(2) -tests.METHODS  In this study, 27 viral cirrhotic patients were enrolled. All subjects underwent neuropsychiatric tests; two or more abnormal results were defined as CD. A logistic regression model was used for multivariate stepwise analysis. A decision-tree algorithm was constructed, and the categorical differences based on the decision-tree model were analyzed by χ(2) -tests.  Multivariate stepwise analysis showed the levels of total bilirubin, triglycerides and free fatty acids (FFA) as independent bioparameters associated with the incidence of CD in cirrhotic patients. The decision-tree algorithm showed that among patients with FFA of 514 mEq/L or more, 77.8% had CD. Meanwhile, among patients with FFA of less than 514 mEq/L and triglycerides of 106 mg/dL or more, 20.0% had CD. The sensitivity, specificity and accuracy for the incidence of CD using the lipid profile (FFA >514 mEq/L or triglycerides <106 mg/dL) were 85.7% (12/14), 61.5% (8/13) and 74.1% (20/27), respectively.RESULTS  Multivariate stepwise analysis showed the levels of total bilirubin, triglycerides and free fatty acids (FFA) as independent bioparameters associated with the incidence of CD in cirrhotic patients. The decision-tree algorithm showed that among patients with FFA of 514 mEq/L or more, 77.8% had CD. Meanwhile, among patients with FFA of less than 514 mEq/L and triglycerides of 106 mg/dL or more, 20.0% had CD. The sensitivity, specificity and accuracy for the incidence of CD using the lipid profile (FFA >514 mEq/L or triglycerides <106 mg/dL) were 85.7% (12/14), 61.5% (8/13) and 74.1% (20/27), respectively.  The levels of total bilirubin, FFA and triglycerides are independently associated with the incidence of CD in cirrhotic patients. In addition, a decision-tree algorithm revealed that FFA of more than 514 mEq/L or triglycerides of less than 106 mg/dL is a profile associated with the incidence of CD. Thus, this lipid profile could be a possible screening bioparameter for CD in cirrhotic patients.CONCLUSION  The levels of total bilirubin, FFA and triglycerides are independently associated with the incidence of CD in cirrhotic patients. In addition, a decision-tree algorithm revealed that FFA of more than 514 mEq/L or triglycerides of less than 106 mg/dL is a profile associated with the incidence of CD. Thus, this lipid profile could be a possible screening bioparameter for CD in cirrhotic patients.
Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision-tree algorithm.   In this study, 27 viral cirrhotic patients were enrolled. All subjects underwent neuropsychiatric tests; two or more abnormal results were defined as CD. A logistic regression model was used for multivariate stepwise analysis. A decision-tree algorithm was constructed, and the categorical differences based on the decision-tree model were analyzed by χ(2) -tests.   Multivariate stepwise analysis showed the levels of total bilirubin, triglycerides and free fatty acids (FFA) as independent bioparameters associated with the incidence of CD in cirrhotic patients. The decision-tree algorithm showed that among patients with FFA of 514 mEq/L or more, 77.8% had CD. Meanwhile, among patients with FFA of less than 514 mEq/L and triglycerides of 106 mg/dL or more, 20.0% had CD. The sensitivity, specificity and accuracy for the incidence of CD using the lipid profile (FFA >514 mEq/L or triglycerides <106 mg/dL) were 85.7% (12/14), 61.5% (8/13) and 74.1% (20/27), respectively.   The levels of total bilirubin, FFA and triglycerides are independently associated with the incidence of CD in cirrhotic patients. In addition, a decision-tree algorithm revealed that FFA of more than 514 mEq/L or triglycerides of less than 106 mg/dL is a profile associated with the incidence of CD. Thus, this lipid profile could be a possible screening bioparameter for CD in cirrhotic patients.
Aim: Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision-tree algorithm. Methods: In this study, 27 viral cirrhotic patients were enrolled. All subjects underwent neuropsychiatric tests; two or more abnormal results were defined as CD. A logistic regression model was used for multivariate stepwise analysis. A decision-tree algorithm was constructed, and the categorical differences based on the decision-tree model were analyzed by chi 2-tests. Results: Multivariate stepwise analysis showed the levels of total bilirubin, triglycerides and free fatty acids (FFA) as independent bioparameters associated with the incidence of CD in cirrhotic patients. The decision-tree algorithm showed that among patients with FFA of 514mEq/L or more, 77.8% had CD. Meanwhile, among patients with FFA of less than 514mEq/L and triglycerides of 106mg/dL or more, 20.0% had CD. The sensitivity, specificity and accuracy for the incidence of CD using the lipid profile (FFA >514mEq/L or triglycerides <106mg/dL) were 85.7% (12/14), 61.5% (8/13) and 74.1% (20/27), respectively. Conclusion: The levels of total bilirubin, FFA and triglycerides are independently associated with the incidence of CD in cirrhotic patients. In addition, a decision-tree algorithm revealed that FFA of more than 514mEq/L or triglycerides of less than 106mg/dL is a profile associated with the incidence of CD. Thus, this lipid profile could be a possible screening bioparameter for CD in cirrhotic patients.
Aim:  Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision‐tree algorithm. Methods:  In this study, 27 viral cirrhotic patients were enrolled. All subjects underwent neuropsychiatric tests; two or more abnormal results were defined as CD. A logistic regression model was used for multivariate stepwise analysis. A decision‐tree algorithm was constructed, and the categorical differences based on the decision‐tree model were analyzed by χ 2 ‐tests. Results:  Multivariate stepwise analysis showed the levels of total bilirubin, triglycerides and free fatty acids (FFA) as independent bioparameters associated with the incidence of CD in cirrhotic patients. The decision‐tree algorithm showed that among patients with FFA of 514 mEq/L or more, 77.8% had CD. Meanwhile, among patients with FFA of less than 514 mEq/L and triglycerides of 106 mg/dL or more, 20.0% had CD. The sensitivity, specificity and accuracy for the incidence of CD using the lipid profile (FFA >514 mEq/L or triglycerides <106 mg/dL) were 85.7% (12/14), 61.5% (8/13) and 74.1% (20/27), respectively. Conclusion:  The levels of total bilirubin, FFA and triglycerides are independently associated with the incidence of CD in cirrhotic patients. In addition, a decision‐tree algorithm revealed that FFA of more than 514 mEq/L or triglycerides of less than 106 mg/dL is a profile associated with the incidence of CD. Thus, this lipid profile could be a possible screening bioparameter for CD in cirrhotic patients.
Aim:  Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision‐tree algorithm. Methods:  In this study, 27 viral cirrhotic patients were enrolled. All subjects underwent neuropsychiatric tests; two or more abnormal results were defined as CD. A logistic regression model was used for multivariate stepwise analysis. A decision‐tree algorithm was constructed, and the categorical differences based on the decision‐tree model were analyzed by χ2‐tests. Results:  Multivariate stepwise analysis showed the levels of total bilirubin, triglycerides and free fatty acids (FFA) as independent bioparameters associated with the incidence of CD in cirrhotic patients. The decision‐tree algorithm showed that among patients with FFA of 514 mEq/L or more, 77.8% had CD. Meanwhile, among patients with FFA of less than 514 mEq/L and triglycerides of 106 mg/dL or more, 20.0% had CD. The sensitivity, specificity and accuracy for the incidence of CD using the lipid profile (FFA >514 mEq/L or triglycerides <106 mg/dL) were 85.7% (12/14), 61.5% (8/13) and 74.1% (20/27), respectively. Conclusion:  The levels of total bilirubin, FFA and triglycerides are independently associated with the incidence of CD in cirrhotic patients. In addition, a decision‐tree algorithm revealed that FFA of more than 514 mEq/L or triglycerides of less than 106 mg/dL is a profile associated with the incidence of CD. Thus, this lipid profile could be a possible screening bioparameter for CD in cirrhotic patients.
Author Kawaguchi, Takumi
Taniguchi, Eitaro
Oriishi, Tetsuharu
Sata, Michio
Sakata, Masahiro
Itou, Minoru
Author_xml – sequence: 1
  givenname: Eitaro
  surname: Taniguchi
  fullname: Taniguchi, Eitaro
  email: eitaro@med.kurume-u.ac.jp
  organization: Division of Gastroenterology, Department of Medicine
– sequence: 2
  givenname: Takumi
  surname: Kawaguchi
  fullname: Kawaguchi, Takumi
  organization: Division of Gastroenterology, Department of Medicine
– sequence: 3
  givenname: Masahiro
  surname: Sakata
  fullname: Sakata, Masahiro
  organization: Division of Gastroenterology, Department of Medicine
– sequence: 4
  givenname: Minoru
  surname: Itou
  fullname: Itou, Minoru
  organization: Division of Gastroenterology, Department of Medicine
– sequence: 5
  givenname: Tetsuharu
  surname: Oriishi
  fullname: Oriishi, Tetsuharu
  organization: Division of Gastroenterology, Department of Medicine
– sequence: 6
  givenname: Michio
  surname: Sata
  fullname: Sata, Michio
  organization: Division of Gastroenterology, Department of Medicine
BackLink https://cir.nii.ac.jp/crid/1571698601100499200$$DView record in CiNii
https://www.ncbi.nlm.nih.gov/pubmed/22882558$$D View this record in MEDLINE/PubMed
BookMark eNqVkU1v1DAQhiNURD_gLyAfOHBJaju243BAqqp-SSuoEAhulmM73Vmyztb2trviz-OwZQ-cig_2yPPMO5p5j4sDP3pXFIjgiuRzuqiIbGiJa_ajopjQChPciGrzojjaJw5yXEtRipqJw-I4xgXGpMGUvSoOKZWSci6Pil8zWIFFqzD2MDgEEekYRwM6OYseIc1Rmudvb8A6bxwae2TGOw8JHhyy29ivvUkw-oygBwh6QAZCmI8JDFrpBM6n-AGdIauTLpfgwd8h7fWwjRBfFy97PUT35uk9Kb5dXnw9vy5nn69uzs9mpWEtE6UUllmhDe170vWs70zb84Y2lje6s8J1knHpupzkVFtJLMc846xztubY1PVJ8X6nm6e8X7uY1BKiccOgvRvXUZGaSdZi0bBnoJS1AuN2Un37hK67pbNqFWCpw1b93W0G5A4wYYwxuH6PEKwmG9VCTW6pyS012aj-2Kg2ufTjP6UGkp72nIKG4T8EHrOr22c3VtcXt1-mMAu82wl4gNx8uglviGilwIRgzNqWYpyxcodBTG6z76PDTyWauuHq-6crNSPstpX8Uon6N0FQ0f4
CitedBy_id crossref_primary_10_1111_hepr_12271
crossref_primary_10_1111_hepr_12192
crossref_primary_10_1111_liv_12235
crossref_primary_10_1177_0884533613496432
crossref_primary_10_1515_cclm_2015_0394
crossref_primary_10_3892_br_2016_640
crossref_primary_10_1111_hepr_12864
crossref_primary_10_3892_or_2013_2700
crossref_primary_10_1007_s10620_017_4862_x
crossref_primary_10_1111_hepr_12144
crossref_primary_10_1155_2012_135780
Cites_doi 10.1053/j.gastro.2010.08.061
10.1093/jn/136.2.553S
10.1016/S0168-8278(03)00267-8
10.1111/j.1478-3231.2009.02009.x
10.1002/hep.21533
10.1111/j.1572-0241.2007.01424.x
10.1007/s11011-006-9042-1
10.1210/en.2007-1722
10.1111/j.1440-1746.2010.06318.x
10.1038/ajg.2010.455
10.1093/ajcn/36.5.950
10.1097/MOP.0b013e32833252f2
10.1016/S0022-2275(20)36723-7
10.1093/oxfordjournals.jbchem.a121860
10.1002/hep.23128
10.1038/ncpgasthep0999
10.1002/hep.24228
10.1159/000171577
10.1016/j.jhep.2010.05.017
10.1126/science.283.5400.397
10.1002/hep.21907
10.1212/WNL.0b013e31820b7656
10.1111/j.1872-034X.2009.00607.x
10.1111/j.1872-034X.2008.00437.x
10.1002/hep.25554
10.1111/j.1572-0241.2001.04130.x
10.1002/hep.510260606
10.1111/j.1872-034X.2008.00441.x
10.1016/j.cmpb.2011.10.005
10.1038/ajg.2010.460
10.1016/j.jhep.2004.11.028
10.1111/j.1872-034X.2008.00374.x
10.1016/S0140-6736(75)90392-X
10.1002/hep.23965
10.2174/156720507780362191
10.1007/BF00684528
10.3748/wjg.v13.i21.3003
10.1111/j.1872-034X.2012.01014.x
10.1016/S0002-9440(10)63408-6
10.1002/hep.25507
10.1016/S0197-4580(03)00087-3
10.1097/MOG.0b013e3283409c25
10.3945/ajcn.2010.29211
10.1002/hep.20095
10.1016/0016-5085(78)90795-3
10.1097/MEG.0b013e32834d1938
10.1016/j.hepres.2004.07.001
10.1038/ajg.2010.413
10.1111/j.1872-034X.2011.00799.x
10.1002/hep.510290115
10.3748/wjg.14.3609
10.1136/gut.2007.122176
10.1007/s11606-009-0918-8
10.1016/j.jhep.2008.04.022
10.1007/s00535-012-0529-8
10.1016/S0021-9258(17)40797-6
ContentType Journal Article
Copyright 2012 The Japan Society of Hepatology
2012 The Japan Society of Hepatology.
Copyright_xml – notice: 2012 The Japan Society of Hepatology
– notice: 2012 The Japan Society of Hepatology.
DBID BSCLL
RYH
AAYXX
CITATION
NPM
7X8
7U9
H94
DOI 10.1111/j.1872-034X.2012.01076.x
DatabaseName Istex
CiNii Complete
CrossRef
PubMed
MEDLINE - Academic
Virology and AIDS Abstracts
AIDS and Cancer Research Abstracts
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
AIDS and Cancer Research Abstracts
Virology and AIDS Abstracts
DatabaseTitleList MEDLINE - Academic
PubMed
AIDS and Cancer Research Abstracts
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1872-034X
EndPage 424
ExternalDocumentID 22882558
10_1111_j_1872_034X_2012_01076_x
HEPR1076
10031194554
ark_67375_WNG_L14P985F_6
Genre shortCommunication
Journal Article
GroupedDBID ---
--K
.3N
.GA
.Y3
05W
0R~
10A
1B1
1OC
1~5
29I
31~
33P
3SF
4.4
4G.
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5GY
5HH
5LA
5VS
66C
7-5
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAEDT
AAESR
AAEVG
AAHQN
AAIPD
AALRI
AAMMB
AAMNL
AANHP
AANLZ
AAONW
AAQFI
AAQXK
AASGY
AAXRX
AAXUO
AAYCA
AAZKR
ABCQN
ABCUV
ABDBF
ABEML
ABIJN
ABJNI
ABPVW
ABQWH
ABWVN
ABXGK
ACAHQ
ACBWZ
ACCZN
ACGFO
ACGFS
ACGOF
ACIUM
ACMXC
ACPOU
ACPRK
ACRPL
ACSCC
ACUHS
ACVFH
ACXBN
ACXQS
ACYXJ
ADBBV
ADBTR
ADCNI
ADEOM
ADIZJ
ADKYN
ADMGS
ADMUD
ADNMO
ADOZA
ADXAS
ADZMN
AEFGJ
AEGXH
AEIGN
AEIMD
AENEX
AEUPX
AEUYR
AEYWJ
AFBPY
AFFPM
AFGKR
AFPUW
AFWVQ
AFZJQ
AGHNM
AGQPQ
AGXDD
AGYGG
AHBTC
AIACR
AIAGR
AIDQK
AIDYY
AIGII
AITUG
AITYG
AIURR
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
ASPBG
ATUGU
AVWKF
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BSCLL
BY8
C45
CAG
COF
CS3
D-6
D-7
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
DU5
EBD
EBS
EJD
ESX
EX3
F00
F01
F04
F5P
FDB
FEDTE
FGOYB
FUBAC
G-Q
G-S
G.N
GODZA
H.X
HF~
HGLYW
HVGLF
HZ~
IHE
IX1
J0M
K48
KBYEO
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
M41
MEWTI
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
NQ-
O66
O9-
OIG
OVD
P2P
P2W
P2X
P2Z
P4B
P4D
Q.N
Q11
QB0
R.K
R2-
ROL
RPZ
RX1
SEW
SSZ
SUPJJ
TEORI
TUS
UB1
UHS
V8K
W8V
W99
WBKPD
WHWMO
WIH
WIJ
WIK
WOHZO
WOW
WQJ
WVDHM
WXI
WXSBR
XG1
ZZTAW
~IA
~WT
AAHHS
ACCFJ
ADZOD
AEEZP
AEQDE
AIWBW
AJBDE
RYH
AEUQT
AFPWT
RIG
WRC
9DU
AAYXX
CITATION
O8X
NPM
7X8
7U9
H94
ID FETCH-LOGICAL-c4946-86d4d6ac2ff1bf4fbc9f5727d57abd6eb8458ebf1b52ad81d5056ac4bed350c33
IEDL.DBID DRFUL
ISICitedReferencesCount 11
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000317304900011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1386-6346
IngestDate Sun Nov 09 09:23:18 EST 2025
Wed Oct 01 14:59:14 EDT 2025
Mon Jul 21 06:06:47 EDT 2025
Sat Nov 29 03:13:47 EST 2025
Tue Nov 18 21:53:58 EST 2025
Wed Jan 22 16:32:46 EST 2025
Thu Jun 26 22:30:53 EDT 2025
Sun Sep 21 06:20:08 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
License http://onlinelibrary.wiley.com/termsAndConditions#vor
2012 The Japan Society of Hepatology.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4946-86d4d6ac2ff1bf4fbc9f5727d57abd6eb8458ebf1b52ad81d5056ac4bed350c33
Notes ark:/67375/WNG-L14P985F-6
ArticleID:HEPR1076
istex:E3BFACB029384615CE6E939D8B503FA45194D8F9
This study was supported, in part, by a Grant‐in‐Aid for Young Scientists (B) (no. 22790874 to T. K.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by Health and Labor Sciences Research Grants for Research on Hepatitis from the Ministry of Health, Labour and Welfare of Japan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Conflict of interest
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
PMID 22882558
PQID 1324960093
PQPubID 23479
PageCount 7
ParticipantIDs proquest_miscellaneous_1348490674
proquest_miscellaneous_1324960093
pubmed_primary_22882558
crossref_primary_10_1111_j_1872_034X_2012_01076_x
crossref_citationtrail_10_1111_j_1872_034X_2012_01076_x
wiley_primary_10_1111_j_1872_034X_2012_01076_x_HEPR1076
nii_cinii_1571698601100499200
istex_primary_ark_67375_WNG_L14P985F_6
PublicationCentury 2000
PublicationDate 2013-04
2013-04-01
April 2013
2013-04-00
2013-Apr
20130401
PublicationDateYYYYMMDD 2013-04-01
PublicationDate_xml – month: 04
  year: 2013
  text: 2013-04
PublicationDecade 2010
PublicationPlace Melbourne, Australia
PublicationPlace_xml – name: Melbourne, Australia
– name: Netherlands
PublicationTitle Hepatology research
PublicationTitleAlternate Hepatol Res
PublicationYear 2013
Publisher Blackwell Publishing Asia
Publisher_xml – name: Blackwell Publishing Asia
References Roman E, Cordoba J, Torrens M et al. Minimal hepatic encephalopathy is associated with falls. Am J Gastroenterol 2011; 106: 476-82.
Raffaitin C, Feart C, Le Goff M et al. Metabolic syndrome and cognitive decline in French elders: the Three-City Study. Neurology 2011; 76: 518-25.
Bajaj JS, Saeian K, Schubert CM et al. Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test. Hepatology 2009; 50: 1175-83.
Bajaj JS, Pinkerton SD, Sanyal AJ, Heuman DM. Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis. Hepatology 2012; 55: 1164-71.
Hashem AM, Rasmy ME, Wahba KM, Shaker OG. Single stage and multistage classification models for the prediction of liver fibrosis degree in patients with chronic hepatitis C infection. Comput Methods Programs Biomed 2012; 105: 194-209.
Kawaguchi T, Yoshida T, Harada M et al. Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3. Am J Pathol 2004; 165: 1499-508.
Bajaj JS, Ananthakrishnan AN, McGinley EL, Hoffmann RG, Brasel KJ. Deleterious effect of cirrhosis on outcomes after motor vehicle crashes using the nationwide inpatient sample. Am J Gastroenterol 2008; 103: 1674-81.
Soltys BJ, Hsia C. Human serum albumin. I. On the relationship of fatty acid and bilirubin binding sites and the nature of fatty acid allosteric effects-a monoanionic spin label study. J Biol Chem 1978; 253: 3023-8.
Lee A, Joynt GM, Ho AM, Keitz S, McGinn T, Wyer PC. Tips for teachers of evidence-based medicine: making sense of decision analysis using a decision tree. J Gen Intern Med 2009; 24: 642-8.
Bajaj JS. Minimal hepatic encephalopathy matters in daily life. World J Gastroenterol 2008; 14: 3609-15.
Kato A, Watanabe Y, Sawara K, Suzuki K. Diagnosis of sub-clinical hepatic encephalopathy by Neuropsychological Tests (NP-tests). Hepatol Res 2008; 38: S122-S7.
Ono J, Hutson DG, Dombro RS, Levi JU, Livingstone A, Zeppa R. Tryptophan and hepatic coma. Gastroenterology 1978; 74: 196-200.
Bach AC, Babayan VK. Medium-chain triglycerides: an update. Am J Clin Nutr 1982; 36: 950-62.
Fernstrom JD, Fernstrom MH. Exercise, serum free tryptophan, and central fatigue. J Nutr 2006; 136: 553S-9S.
Bajaj JS, Heuman DM, Wade JB et al. Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy. Gastroenterology 2011; 140: 478-87. e1.
Otsuka M, Uchida Y, Kawaguchi T et al. Fish to meat intake ratio and cooking oils are associated with hepatitis C virus carriers with persistently normal alanine aminotransferase levels. Hepatol Res 2012; in press.
Wein C, Koch H, Popp B, Oehler G, Schauder P. Minimal hepatic encephalopathy impairs fitness to drive. Hepatology 2004; 39: 739-45.
Blei AT, Cordoba J. Subclinical encephalopathy. Dig Dis 1996; 14 (Suppl 1): 2-11.
Sidhu SS, Goyal O, Mishra BP, Sood A, Chhina RS, Soni RK. Rifaximin improves psychometric performance and health-related quality of life in patients with minimal hepatic encephalopathy (the RIME Trial). Am J Gastroenterol 2011; 106: 307-16.
Bao ZJ, Qiu DK, Ma X et al. Assessment of health-related quality of life in Chinese patients with minimal hepatic encephalopathy. World J Gastroenterol 2007; 13: 3003-8.
Kawaguchi T, Sakisaka S, Sata M, Mori M, Tanikawa K. Different lobular distributions of altered hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis. Hepatology 1999; 29: 205-16.
Nakayama N, Oketani M, Kawamura Y et al. Algorithm to determine the outcome of patients with acute liver failure: a data-mining analysis using decision trees. J Gastroenterol 2012; 47: 644-77.
Kachaamy T, Bajaj JS. Diet and cognition in chronic liver disease. Curr Opin Gastroenterol 2011; 27: 174-9.
Amodio P, Campagna F, Olianas S et al. Detection of minimal hepatic encephalopathy: normalization and optimization of the Psychometric Hepatic Encephalopathy Score. A neuropsychological and quantified EEG study. J Hepatol 2008; 49: 346-53.
Randolph C, Hilsabeck R, Kato A et al. Neuropsychological assessment of hepatic encephalopathy: ISHEN practice guidelines. Liver Int 2009; 29: 629-35.
Ortiz M, Jacas C, Cordoba J. Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol 2005; 42: S45-53.
Yaffe K. Metabolic syndrome and cognitive decline. Curr Alzheimer Res 2007; 4: 123-6.
Dhiman RK, Saraswat VA, Sharma BK et al. Minimal hepatic encephalopathy: consensus statement of a working party of the Indian National Association for Study of the Liver. J Gastroenterol Hepatol 2010; 25: 1029-41.
Luo M, Li L, Lu CZ, Cao WK. Clinical efficacy and safety of lactulose for minimal hepatic encephalopathy: a meta-analysis. Eur J Gastroenterol Hepatol 2011; 23: 1250-7.
Kurosaki M, Matsunaga K, Hirayama I et al. A predictive model of response to peginterferon ribavirin in chronic hepatitis C using classification and regression tree analysis. Hepatol Res 2010; 40: 251-60.
Reger MA, Henderson ST, Hale C et al. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging 2004; 25: 311-14.
Lantos PL, Aminoff MJ. Fine structural changes in the sural nerve of patients with acanthocytosis. Acta Neuropathol 1972; 22: 257-63.
Prasad S, Dhiman RK, Duseja A, Chawla YK, Sharma A, Agarwal R. Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology 2007; 45: 549-59.
Michitaka K, Tokumoto Y, Uesugi K et al. Neuropsychiatric dysfunction in patients with chronic hepatitis and liver cirrhosis. Hepatol Res 2008; 38: 1069-75.
Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 1999; 283: 397-401.
Farr SA, Yamada KA, Butterfield DA et al. Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology 2008; 149: 2628-36.
Shawcross DL, Wright G, Olde Damink SW, Jalan R. Role of ammonia and inflammation in minimal hepatic encephalopathy. Metab Brain Dis 2007; 22: 125-38.
Bajaj JS, Hafeezullah M, Hoffmann RG, Saeian K. Minimal hepatic encephalopathy: a vehicle for accidents and traffic violations. Am J Gastroenterol 2007; 102: 1903-9.
Buonuomo PS, Ruggiero A, Valeriani M, Mariotti P. Familial hypobetalipoproteinemia: early neurological, hematological, and ocular manifestations in two affected twins responding to vitamin supplementation. Curr Opin Pediatr 2009; 21: 824-7.
Butterworth RF. Hepatic encephalopathy: a central neuroinflammatory disorder? Hepatology 2011; 53: 1372-6.
Kato A, Kato M, Ishii H et al. Development of quantitative neuropsychological tests for diagnosis of subclinical hepatic encephalopathy in liver cirrhosis patients and establishment of diagnostic criteria-multicenter collaborative study in Japanese. Hepatol Res 2004; 30: 71-8.
Butterworth RF. Editorial: rifaximin and minimal hepatic encephalopathy. Am J Gastroenterol 2011; 106: 317-18.
Stewart CA, Smith GE. Minimal hepatic encephalopathy. Nat Clin Pract Gastroenterol Hepatol 2007; 4: 677-85.
Vaisman N, Katzman H, Carmiel-Haggai M, Lusthaus M, Niv E. Breakfast improves cognitive function in cirrhotic patients with cognitive impairment. Am J Clin Nutr 2010; 92: 137-40.
Haussinger D, Schliess F. Pathogenetic mechanisms of hepatic encephalopathy. Gut 2008; 57: 1156-65.
Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007; 46: 922-38.
Gupta A, Dhiman RK, Kumari S et al. Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy. J Hepatol 2010; 53: 849-55.
Kawaguchi T, Kakuma T, Yatsuhashi H et al. Data mining reveals complex interactions of risk factors and clinical feature profiling associated with the staging of non-hepatitis B virus/non-hepatitis C virus-related hepatocellular carcinoma. Hepatol Res 2011; 41: 564-71.
Butterworth RF. Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies. J Hepatol 2003; 39: 278-85.
Lal S, Young SN, Sourkes TL. Letter: 5-hydroxytryptamine and hepatic coma. Lancet 1975; 2: 979-80.
Soriano G, Roman E, Cordoba J et al. Cognitive dysfunction in cirrhosis is associated with falls: a prospective study. Hepatology 2012; 55: 1922-30.
Spector AA. Fatty acid binding to plasma albumin. J Lipid Res 1975; 16: 165-79.
Oida T. 1H-NMR study on the interactions of human serum albumin with free fatty acid. J Biochem 1986; 100: 1533-42.
Watanabe A, Sakai T, Sato S et al. Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy. Hepatology 1997; 26: 1410-14.
Seyama Y, Kokudo N. Assessment of liver function for safe hepatic resection. Hepatol Res 2009; 39: 107-16.
Romero-Gomez M, Boza F, Garcia-Valdecasas MS, Garcia E, Aguilar-Reina J. Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy. Am J Gastroenterol 2001; 96: 2718-23.
Rossi S, Ravetta V, Rosa L et al. Repeated radiofrequency ablation for management of patients with cirrhosis with small hepatocellular carcinomas: a long-term cohort study. Hepatology 2011; 53: 136-47.
2004; 165
2007; 102
2010; 53
1978; 74
2004; 25
1975; 16
2008; 38
2011; 53
1999; 283
1978; 253
2008; 149
2008; 103
2012; 55
2006; 136
2004; 30
2010; 25
2009; 50
2004; 39
1986; 100
1975; 2
2007; 4
2011; 23
2011; 27
2007; 22
2001; 96
1982; 36
2009; 24
2009; 21
2012
1999; 29
1997; 26
2008; 14
2005; 42
2008; 57
2011; 76
2003; 39
1996; 14
2012; 105
1972; 22
2007; 13
2010; 40
2009; 29
2011; 106
2008; 49
2011; 41
2012; 47
2010; 92
2011; 140
2007; 45
2007; 46
2009; 39
e_1_2_5_27_2
e_1_2_5_48_2
e_1_2_5_25_2
e_1_2_5_46_2
e_1_2_5_23_2
e_1_2_5_44_2
e_1_2_5_21_2
e_1_2_5_42_2
e_1_2_5_29_2
e_1_2_5_40_2
e_1_2_5_13_2
e_1_2_5_38_2
e_1_2_5_59_2
e_1_2_5_9_2
e_1_2_5_15_2
e_1_2_5_36_2
e_1_2_5_57_2
e_1_2_5_7_2
e_1_2_5_34_2
e_1_2_5_55_2
e_1_2_5_5_2
e_1_2_5_11_2
e_1_2_5_32_2
e_1_2_5_53_2
e_1_2_5_3_2
e_1_2_5_17_2
e_1_2_5_19_2
e_1_2_5_30_2
e_1_2_5_51_2
e_1_2_5_26_2
e_1_2_5_49_2
e_1_2_5_24_2
e_1_2_5_47_2
e_1_2_5_22_2
e_1_2_5_45_2
e_1_2_5_20_2
Bajaj JS (e_1_2_5_56_2) 2008; 103
e_1_2_5_28_2
e_1_2_5_41_2
e_1_2_5_14_2
e_1_2_5_37_2
e_1_2_5_16_2
e_1_2_5_35_2
e_1_2_5_58_2
e_1_2_5_8_2
e_1_2_5_10_2
e_1_2_5_33_2
e_1_2_5_6_2
e_1_2_5_12_2
e_1_2_5_31_2
e_1_2_5_54_2
e_1_2_5_4_2
e_1_2_5_2_2
e_1_2_5_18_2
e_1_2_5_39_2
Soltys BJ (e_1_2_5_43_2) 1978; 253
e_1_2_5_52_2
e_1_2_5_50_2
References_xml – reference: Sidhu SS, Goyal O, Mishra BP, Sood A, Chhina RS, Soni RK. Rifaximin improves psychometric performance and health-related quality of life in patients with minimal hepatic encephalopathy (the RIME Trial). Am J Gastroenterol 2011; 106: 307-16.
– reference: Blei AT, Cordoba J. Subclinical encephalopathy. Dig Dis 1996; 14 (Suppl 1): 2-11.
– reference: Otsuka M, Uchida Y, Kawaguchi T et al. Fish to meat intake ratio and cooking oils are associated with hepatitis C virus carriers with persistently normal alanine aminotransferase levels. Hepatol Res 2012; in press.
– reference: Farr SA, Yamada KA, Butterfield DA et al. Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology 2008; 149: 2628-36.
– reference: Kato A, Kato M, Ishii H et al. Development of quantitative neuropsychological tests for diagnosis of subclinical hepatic encephalopathy in liver cirrhosis patients and establishment of diagnostic criteria-multicenter collaborative study in Japanese. Hepatol Res 2004; 30: 71-8.
– reference: Watanabe A, Sakai T, Sato S et al. Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy. Hepatology 1997; 26: 1410-14.
– reference: Bajaj JS. Minimal hepatic encephalopathy matters in daily life. World J Gastroenterol 2008; 14: 3609-15.
– reference: Kurosaki M, Matsunaga K, Hirayama I et al. A predictive model of response to peginterferon ribavirin in chronic hepatitis C using classification and regression tree analysis. Hepatol Res 2010; 40: 251-60.
– reference: Fernstrom JD, Fernstrom MH. Exercise, serum free tryptophan, and central fatigue. J Nutr 2006; 136: 553S-9S.
– reference: Ono J, Hutson DG, Dombro RS, Levi JU, Livingstone A, Zeppa R. Tryptophan and hepatic coma. Gastroenterology 1978; 74: 196-200.
– reference: Kawaguchi T, Sakisaka S, Sata M, Mori M, Tanikawa K. Different lobular distributions of altered hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis. Hepatology 1999; 29: 205-16.
– reference: Dhiman RK, Saraswat VA, Sharma BK et al. Minimal hepatic encephalopathy: consensus statement of a working party of the Indian National Association for Study of the Liver. J Gastroenterol Hepatol 2010; 25: 1029-41.
– reference: Lal S, Young SN, Sourkes TL. Letter: 5-hydroxytryptamine and hepatic coma. Lancet 1975; 2: 979-80.
– reference: Prasad S, Dhiman RK, Duseja A, Chawla YK, Sharma A, Agarwal R. Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology 2007; 45: 549-59.
– reference: Yaffe K. Metabolic syndrome and cognitive decline. Curr Alzheimer Res 2007; 4: 123-6.
– reference: Bajaj JS, Pinkerton SD, Sanyal AJ, Heuman DM. Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis. Hepatology 2012; 55: 1164-71.
– reference: Bach AC, Babayan VK. Medium-chain triglycerides: an update. Am J Clin Nutr 1982; 36: 950-62.
– reference: Soriano G, Roman E, Cordoba J et al. Cognitive dysfunction in cirrhosis is associated with falls: a prospective study. Hepatology 2012; 55: 1922-30.
– reference: Haussinger D, Schliess F. Pathogenetic mechanisms of hepatic encephalopathy. Gut 2008; 57: 1156-65.
– reference: Buonuomo PS, Ruggiero A, Valeriani M, Mariotti P. Familial hypobetalipoproteinemia: early neurological, hematological, and ocular manifestations in two affected twins responding to vitamin supplementation. Curr Opin Pediatr 2009; 21: 824-7.
– reference: Reger MA, Henderson ST, Hale C et al. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging 2004; 25: 311-14.
– reference: Butterworth RF. Hepatic encephalopathy: a central neuroinflammatory disorder? Hepatology 2011; 53: 1372-6.
– reference: Kawaguchi T, Yoshida T, Harada M et al. Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3. Am J Pathol 2004; 165: 1499-508.
– reference: Rossi S, Ravetta V, Rosa L et al. Repeated radiofrequency ablation for management of patients with cirrhosis with small hepatocellular carcinomas: a long-term cohort study. Hepatology 2011; 53: 136-47.
– reference: Butterworth RF. Editorial: rifaximin and minimal hepatic encephalopathy. Am J Gastroenterol 2011; 106: 317-18.
– reference: Amodio P, Campagna F, Olianas S et al. Detection of minimal hepatic encephalopathy: normalization and optimization of the Psychometric Hepatic Encephalopathy Score. A neuropsychological and quantified EEG study. J Hepatol 2008; 49: 346-53.
– reference: Bajaj JS, Heuman DM, Wade JB et al. Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy. Gastroenterology 2011; 140: 478-87. e1.
– reference: Bao ZJ, Qiu DK, Ma X et al. Assessment of health-related quality of life in Chinese patients with minimal hepatic encephalopathy. World J Gastroenterol 2007; 13: 3003-8.
– reference: Luo M, Li L, Lu CZ, Cao WK. Clinical efficacy and safety of lactulose for minimal hepatic encephalopathy: a meta-analysis. Eur J Gastroenterol Hepatol 2011; 23: 1250-7.
– reference: Bajaj JS, Ananthakrishnan AN, McGinley EL, Hoffmann RG, Brasel KJ. Deleterious effect of cirrhosis on outcomes after motor vehicle crashes using the nationwide inpatient sample. Am J Gastroenterol 2008; 103: 1674-81.
– reference: Wein C, Koch H, Popp B, Oehler G, Schauder P. Minimal hepatic encephalopathy impairs fitness to drive. Hepatology 2004; 39: 739-45.
– reference: Vaisman N, Katzman H, Carmiel-Haggai M, Lusthaus M, Niv E. Breakfast improves cognitive function in cirrhotic patients with cognitive impairment. Am J Clin Nutr 2010; 92: 137-40.
– reference: Randolph C, Hilsabeck R, Kato A et al. Neuropsychological assessment of hepatic encephalopathy: ISHEN practice guidelines. Liver Int 2009; 29: 629-35.
– reference: Kato A, Watanabe Y, Sawara K, Suzuki K. Diagnosis of sub-clinical hepatic encephalopathy by Neuropsychological Tests (NP-tests). Hepatol Res 2008; 38: S122-S7.
– reference: Ortiz M, Jacas C, Cordoba J. Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol 2005; 42: S45-53.
– reference: Shawcross DL, Wright G, Olde Damink SW, Jalan R. Role of ammonia and inflammation in minimal hepatic encephalopathy. Metab Brain Dis 2007; 22: 125-38.
– reference: Lee A, Joynt GM, Ho AM, Keitz S, McGinn T, Wyer PC. Tips for teachers of evidence-based medicine: making sense of decision analysis using a decision tree. J Gen Intern Med 2009; 24: 642-8.
– reference: Hashem AM, Rasmy ME, Wahba KM, Shaker OG. Single stage and multistage classification models for the prediction of liver fibrosis degree in patients with chronic hepatitis C infection. Comput Methods Programs Biomed 2012; 105: 194-209.
– reference: Lantos PL, Aminoff MJ. Fine structural changes in the sural nerve of patients with acanthocytosis. Acta Neuropathol 1972; 22: 257-63.
– reference: Roman E, Cordoba J, Torrens M et al. Minimal hepatic encephalopathy is associated with falls. Am J Gastroenterol 2011; 106: 476-82.
– reference: Gupta A, Dhiman RK, Kumari S et al. Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy. J Hepatol 2010; 53: 849-55.
– reference: Spector AA. Fatty acid binding to plasma albumin. J Lipid Res 1975; 16: 165-79.
– reference: Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 1999; 283: 397-401.
– reference: Seyama Y, Kokudo N. Assessment of liver function for safe hepatic resection. Hepatol Res 2009; 39: 107-16.
– reference: Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007; 46: 922-38.
– reference: Michitaka K, Tokumoto Y, Uesugi K et al. Neuropsychiatric dysfunction in patients with chronic hepatitis and liver cirrhosis. Hepatol Res 2008; 38: 1069-75.
– reference: Bajaj JS, Saeian K, Schubert CM et al. Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test. Hepatology 2009; 50: 1175-83.
– reference: Nakayama N, Oketani M, Kawamura Y et al. Algorithm to determine the outcome of patients with acute liver failure: a data-mining analysis using decision trees. J Gastroenterol 2012; 47: 644-77.
– reference: Romero-Gomez M, Boza F, Garcia-Valdecasas MS, Garcia E, Aguilar-Reina J. Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy. Am J Gastroenterol 2001; 96: 2718-23.
– reference: Kawaguchi T, Kakuma T, Yatsuhashi H et al. Data mining reveals complex interactions of risk factors and clinical feature profiling associated with the staging of non-hepatitis B virus/non-hepatitis C virus-related hepatocellular carcinoma. Hepatol Res 2011; 41: 564-71.
– reference: Oida T. 1H-NMR study on the interactions of human serum albumin with free fatty acid. J Biochem 1986; 100: 1533-42.
– reference: Kachaamy T, Bajaj JS. Diet and cognition in chronic liver disease. Curr Opin Gastroenterol 2011; 27: 174-9.
– reference: Stewart CA, Smith GE. Minimal hepatic encephalopathy. Nat Clin Pract Gastroenterol Hepatol 2007; 4: 677-85.
– reference: Butterworth RF. Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies. J Hepatol 2003; 39: 278-85.
– reference: Soltys BJ, Hsia C. Human serum albumin. I. On the relationship of fatty acid and bilirubin binding sites and the nature of fatty acid allosteric effects-a monoanionic spin label study. J Biol Chem 1978; 253: 3023-8.
– reference: Bajaj JS, Hafeezullah M, Hoffmann RG, Saeian K. Minimal hepatic encephalopathy: a vehicle for accidents and traffic violations. Am J Gastroenterol 2007; 102: 1903-9.
– reference: Raffaitin C, Feart C, Le Goff M et al. Metabolic syndrome and cognitive decline in French elders: the Three-City Study. Neurology 2011; 76: 518-25.
– volume: 50
  start-page: 1175
  year: 2009
  end-page: 83
  article-title: Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test
  publication-title: Hepatology
– volume: 55
  start-page: 1164
  year: 2012
  end-page: 71
  article-title: Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost‐effectiveness analysis
  publication-title: Hepatology
– volume: 29
  start-page: 205
  year: 1999
  end-page: 16
  article-title: Different lobular distributions of altered hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis
  publication-title: Hepatology
– volume: 29
  start-page: 629
  year: 2009
  end-page: 35
  article-title: Neuropsychological assessment of hepatic encephalopathy: ISHEN practice guidelines
  publication-title: Liver Int
– volume: 16
  start-page: 165
  year: 1975
  end-page: 79
  article-title: Fatty acid binding to plasma albumin
  publication-title: J Lipid Res
– volume: 4
  start-page: 677
  year: 2007
  end-page: 85
  article-title: Minimal hepatic encephalopathy
  publication-title: Nat Clin Pract Gastroenterol Hepatol
– volume: 76
  start-page: 518
  year: 2011
  end-page: 25
  article-title: Metabolic syndrome and cognitive decline in French elders: the Three‐City Study
  publication-title: Neurology
– volume: 149
  start-page: 2628
  year: 2008
  end-page: 36
  article-title: Obesity and hypertriglyceridemia produce cognitive impairment
  publication-title: Endocrinology
– volume: 47
  start-page: 644
  year: 2012
  end-page: 77
  article-title: Algorithm to determine the outcome of patients with acute liver failure: a data‐mining analysis using decision trees
  publication-title: J Gastroenterol
– volume: 24
  start-page: 642
  year: 2009
  end-page: 8
  article-title: Tips for teachers of evidence‐based medicine: making sense of decision analysis using a decision tree
  publication-title: J Gen Intern Med
– volume: 74
  start-page: 196
  year: 1978
  end-page: 200
  article-title: Tryptophan and hepatic coma
  publication-title: Gastroenterology
– volume: 38
  start-page: 1069
  year: 2008
  end-page: 75
  article-title: Neuropsychiatric dysfunction in patients with chronic hepatitis and liver cirrhosis
  publication-title: Hepatol Res
– volume: 25
  start-page: 311
  year: 2004
  end-page: 14
  article-title: Effects of beta‐hydroxybutyrate on cognition in memory‐impaired adults
  publication-title: Neurobiol Aging
– volume: 14
  start-page: 3609
  year: 2008
  end-page: 15
  article-title: Minimal hepatic encephalopathy matters in daily life
  publication-title: World J Gastroenterol
– volume: 13
  start-page: 3003
  year: 2007
  end-page: 8
  article-title: Assessment of health‐related quality of life in Chinese patients with minimal hepatic encephalopathy
  publication-title: World J Gastroenterol
– volume: 26
  start-page: 1410
  year: 1997
  end-page: 14
  article-title: Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy
  publication-title: Hepatology
– volume: 4
  start-page: 123
  year: 2007
  end-page: 6
  article-title: Metabolic syndrome and cognitive decline
  publication-title: Curr Alzheimer Res
– volume: 41
  start-page: 564
  year: 2011
  end-page: 71
  article-title: Data mining reveals complex interactions of risk factors and clinical feature profiling associated with the staging of non‐hepatitis B virus/non‐hepatitis C virus‐related hepatocellular carcinoma
  publication-title: Hepatol Res
– volume: 53
  start-page: 1372
  year: 2011
  end-page: 6
  article-title: Hepatic encephalopathy: a central neuroinflammatory disorder?
  publication-title: Hepatology
– volume: 14
  start-page: 2
  issue: 1
  year: 1996
  end-page: 11
  article-title: Subclinical encephalopathy
  publication-title: Dig Dis
– volume: 27
  start-page: 174
  year: 2011
  end-page: 9
  article-title: Diet and cognition in chronic liver disease
  publication-title: Curr Opin Gastroenterol
– volume: 100
  start-page: 1533
  year: 1986
  end-page: 42
  article-title: 1H‐NMR study on the interactions of human serum albumin with free fatty acid
  publication-title: J Biochem
– volume: 102
  start-page: 1903
  year: 2007
  end-page: 9
  article-title: Minimal hepatic encephalopathy: a vehicle for accidents and traffic violations
  publication-title: Am J Gastroenterol
– volume: 39
  start-page: 278
  year: 2003
  end-page: 85
  article-title: Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies
  publication-title: J Hepatol
– volume: 42
  start-page: S45
  year: 2005
  end-page: 53
  article-title: Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations
  publication-title: J Hepatol
– year: 2012
  article-title: Fish to meat intake ratio and cooking oils are associated with hepatitis C virus carriers with persistently normal alanine aminotransferase levels
  publication-title: Hepatol Res
– volume: 283
  start-page: 397
  year: 1999
  end-page: 401
  article-title: Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
  publication-title: Science
– volume: 22
  start-page: 125
  year: 2007
  end-page: 38
  article-title: Role of ammonia and inflammation in minimal hepatic encephalopathy
  publication-title: Metab Brain Dis
– volume: 40
  start-page: 251
  year: 2010
  end-page: 60
  article-title: A predictive model of response to peginterferon ribavirin in chronic hepatitis C using classification and regression tree analysis
  publication-title: Hepatol Res
– volume: 103
  start-page: 1674
  year: 2008
  end-page: 81
  article-title: Deleterious effect of cirrhosis on outcomes after motor vehicle crashes using the nationwide inpatient sample
  publication-title: Am J Gastroenterol
– volume: 253
  start-page: 3023
  year: 1978
  end-page: 8
  article-title: Human serum albumin. I. On the relationship of fatty acid and bilirubin binding sites and the nature of fatty acid allosteric effects–a monoanionic spin label study
  publication-title: J Biol Chem
– volume: 39
  start-page: 739
  year: 2004
  end-page: 45
  article-title: Minimal hepatic encephalopathy impairs fitness to drive
  publication-title: Hepatology
– volume: 46
  start-page: 922
  year: 2007
  end-page: 38
  article-title: Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
  publication-title: Hepatology
– volume: 136
  start-page: 553S
  year: 2006
  end-page: 9S
  article-title: Exercise, serum free tryptophan, and central fatigue
  publication-title: J Nutr
– volume: 106
  start-page: 317
  year: 2011
  end-page: 18
  article-title: Editorial: rifaximin and minimal hepatic encephalopathy
  publication-title: Am J Gastroenterol
– volume: 22
  start-page: 257
  year: 1972
  end-page: 63
  article-title: Fine structural changes in the sural nerve of patients with acanthocytosis
  publication-title: Acta Neuropathol
– volume: 36
  start-page: 950
  year: 1982
  end-page: 62
  article-title: Medium‐chain triglycerides: an update
  publication-title: Am J Clin Nutr
– volume: 38
  start-page: S122
  year: 2008
  end-page: S7
  article-title: Diagnosis of sub‐clinical hepatic encephalopathy by Neuropsychological Tests (NP‐tests)
  publication-title: Hepatol Res
– volume: 57
  start-page: 1156
  year: 2008
  end-page: 65
  article-title: Pathogenetic mechanisms of hepatic encephalopathy
  publication-title: Gut
– volume: 49
  start-page: 346
  year: 2008
  end-page: 53
  article-title: Detection of minimal hepatic encephalopathy: normalization and optimization of the Psychometric Hepatic Encephalopathy Score. A neuropsychological and quantified EEG study
  publication-title: J Hepatol
– volume: 53
  start-page: 136
  year: 2011
  end-page: 47
  article-title: Repeated radiofrequency ablation for management of patients with cirrhosis with small hepatocellular carcinomas: a long‐term cohort study
  publication-title: Hepatology
– volume: 140
  start-page: 478
  year: 2011
  end-page: 87
  article-title: Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
  publication-title: Gastroenterology
– volume: 39
  start-page: 107
  year: 2009
  end-page: 16
  article-title: Assessment of liver function for safe hepatic resection
  publication-title: Hepatol Res
– volume: 45
  start-page: 549
  year: 2007
  end-page: 59
  article-title: Lactulose improves cognitive functions and health‐related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy
  publication-title: Hepatology
– volume: 21
  start-page: 824
  year: 2009
  end-page: 7
  article-title: Familial hypobetalipoproteinemia: early neurological, hematological, and ocular manifestations in two affected twins responding to vitamin supplementation
  publication-title: Curr Opin Pediatr
– volume: 106
  start-page: 307
  year: 2011
  end-page: 16
  article-title: Rifaximin improves psychometric performance and health‐related quality of life in patients with minimal hepatic encephalopathy (the RIME Trial)
  publication-title: Am J Gastroenterol
– volume: 55
  start-page: 1922
  year: 2012
  end-page: 30
  article-title: Cognitive dysfunction in cirrhosis is associated with falls: a prospective study
  publication-title: Hepatology
– volume: 53
  start-page: 849
  year: 2010
  end-page: 55
  article-title: Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy
  publication-title: J Hepatol
– volume: 2
  start-page: 979
  year: 1975
  end-page: 80
  article-title: Letter: 5‐hydroxytryptamine and hepatic coma
  publication-title: Lancet
– volume: 96
  start-page: 2718
  year: 2001
  end-page: 23
  article-title: Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy
  publication-title: Am J Gastroenterol
– volume: 105
  start-page: 194
  year: 2012
  end-page: 209
  article-title: Single stage and multistage classification models for the prediction of liver fibrosis degree in patients with chronic hepatitis C infection
  publication-title: Comput Methods Programs Biomed
– volume: 25
  start-page: 1029
  year: 2010
  end-page: 41
  article-title: Minimal hepatic encephalopathy: consensus statement of a working party of the Indian National Association for Study of the Liver
  publication-title: J Gastroenterol Hepatol
– volume: 30
  start-page: 71
  year: 2004
  end-page: 8
  article-title: Development of quantitative neuropsychological tests for diagnosis of subclinical hepatic encephalopathy in liver cirrhosis patients and establishment of diagnostic criteria‐multicenter collaborative study in Japanese
  publication-title: Hepatol Res
– volume: 106
  start-page: 476
  year: 2011
  end-page: 82
  article-title: Minimal hepatic encephalopathy is associated with falls
  publication-title: Am J Gastroenterol
– volume: 23
  start-page: 1250
  year: 2011
  end-page: 7
  article-title: Clinical efficacy and safety of lactulose for minimal hepatic encephalopathy: a meta‐analysis
  publication-title: Eur J Gastroenterol Hepatol
– volume: 92
  start-page: 137
  year: 2010
  end-page: 40
  article-title: Breakfast improves cognitive function in cirrhotic patients with cognitive impairment
  publication-title: Am J Clin Nutr
– volume: 165
  start-page: 1499
  year: 2004
  end-page: 508
  article-title: Hepatitis C virus down‐regulates insulin receptor substrates 1 and 2 through up‐regulation of suppressor of cytokine signaling 3
  publication-title: Am J Pathol
– ident: e_1_2_5_22_2
  doi: 10.1053/j.gastro.2010.08.061
– ident: e_1_2_5_44_2
  doi: 10.1093/jn/136.2.553S
– ident: e_1_2_5_36_2
  doi: 10.1016/S0168-8278(03)00267-8
– ident: e_1_2_5_38_2
  doi: 10.1111/j.1478-3231.2009.02009.x
– ident: e_1_2_5_9_2
  doi: 10.1002/hep.21533
– ident: e_1_2_5_12_2
  doi: 10.1111/j.1572-0241.2007.01424.x
– ident: e_1_2_5_20_2
  doi: 10.1007/s11011-006-9042-1
– ident: e_1_2_5_48_2
  doi: 10.1210/en.2007-1722
– ident: e_1_2_5_7_2
  doi: 10.1111/j.1440-1746.2010.06318.x
– ident: e_1_2_5_10_2
  doi: 10.1038/ajg.2010.455
– ident: e_1_2_5_51_2
  doi: 10.1093/ajcn/36.5.950
– ident: e_1_2_5_53_2
  doi: 10.1097/MOP.0b013e32833252f2
– ident: e_1_2_5_41_2
  doi: 10.1016/S0022-2275(20)36723-7
– ident: e_1_2_5_42_2
  doi: 10.1093/oxfordjournals.jbchem.a121860
– ident: e_1_2_5_14_2
  doi: 10.1002/hep.23128
– ident: e_1_2_5_37_2
  doi: 10.1038/ncpgasthep0999
– ident: e_1_2_5_39_2
  doi: 10.1002/hep.24228
– ident: e_1_2_5_24_2
  doi: 10.1159/000171577
– ident: e_1_2_5_18_2
  doi: 10.1016/j.jhep.2010.05.017
– ident: e_1_2_5_47_2
  doi: 10.1126/science.283.5400.397
– ident: e_1_2_5_2_2
  doi: 10.1002/hep.21907
– ident: e_1_2_5_49_2
  doi: 10.1212/WNL.0b013e31820b7656
– ident: e_1_2_5_29_2
  doi: 10.1111/j.1872-034X.2009.00607.x
– ident: e_1_2_5_58_2
  doi: 10.1111/j.1872-034X.2008.00437.x
– ident: e_1_2_5_57_2
  doi: 10.1002/hep.25554
– ident: e_1_2_5_6_2
  doi: 10.1111/j.1572-0241.2001.04130.x
– ident: e_1_2_5_19_2
  doi: 10.1002/hep.510260606
– ident: e_1_2_5_31_2
  doi: 10.1111/j.1872-034X.2008.00441.x
– ident: e_1_2_5_30_2
  doi: 10.1016/j.cmpb.2011.10.005
– ident: e_1_2_5_55_2
  doi: 10.1038/ajg.2010.460
– ident: e_1_2_5_5_2
  doi: 10.1016/j.jhep.2004.11.028
– ident: e_1_2_5_33_2
  doi: 10.1111/j.1872-034X.2008.00374.x
– ident: e_1_2_5_16_2
  doi: 10.1002/hep.25554
– ident: e_1_2_5_45_2
  doi: 10.1016/S0140-6736(75)90392-X
– ident: e_1_2_5_3_2
  doi: 10.1002/hep.23965
– ident: e_1_2_5_50_2
  doi: 10.2174/156720507780362191
– ident: e_1_2_5_52_2
  doi: 10.1007/BF00684528
– volume: 103
  start-page: 1674
  year: 2008
  ident: e_1_2_5_56_2
  article-title: Deleterious effect of cirrhosis on outcomes after motor vehicle crashes using the nationwide inpatient sample
  publication-title: Am J Gastroenterol
– ident: e_1_2_5_8_2
  doi: 10.3748/wjg.v13.i21.3003
– ident: e_1_2_5_27_2
  doi: 10.1111/j.1872-034X.2012.01014.x
– ident: e_1_2_5_35_2
  doi: 10.1016/S0002-9440(10)63408-6
– ident: e_1_2_5_17_2
  doi: 10.1002/hep.25507
– ident: e_1_2_5_54_2
  doi: 10.1016/S0197-4580(03)00087-3
– ident: e_1_2_5_25_2
  doi: 10.1097/MOG.0b013e3283409c25
– ident: e_1_2_5_40_2
  doi: 10.3945/ajcn.2010.29211
– ident: e_1_2_5_11_2
  doi: 10.1002/hep.20095
– ident: e_1_2_5_46_2
  doi: 10.1016/0016-5085(78)90795-3
– ident: e_1_2_5_23_2
  doi: 10.1097/MEG.0b013e32834d1938
– ident: e_1_2_5_4_2
  doi: 10.1016/j.hepres.2004.07.001
– ident: e_1_2_5_15_2
  doi: 10.1038/ajg.2010.413
– ident: e_1_2_5_26_2
  doi: 10.1111/j.1872-034X.2011.00799.x
– ident: e_1_2_5_34_2
  doi: 10.1002/hep.510290115
– ident: e_1_2_5_13_2
  doi: 10.3748/wjg.14.3609
– ident: e_1_2_5_21_2
  doi: 10.1136/gut.2007.122176
– ident: e_1_2_5_28_2
  doi: 10.1007/s11606-009-0918-8
– ident: e_1_2_5_59_2
  doi: 10.1016/j.jhep.2008.04.022
– ident: e_1_2_5_32_2
  doi: 10.1007/s00535-012-0529-8
– volume: 253
  start-page: 3023
  year: 1978
  ident: e_1_2_5_43_2
  article-title: Human serum albumin. I. On the relationship of fatty acid and bilirubin binding sites and the nature of fatty acid allosteric effects–a monoanionic spin label study
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(17)40797-6
SSID ssj0017024
Score 2.0560665
Snippet Aim:  Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We...
Aim:  Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We...
Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated...
Aim: Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We...
SourceID proquest
pubmed
crossref
wiley
nii
istex
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 418
SubjectTerms Algorithms
decision-tree algorithm
fatty acid
minimal hepatic encephalopathy
neuropsychiatric test
neurospsychiatric test
Title Lipid profile is associated with the incidence of cognitive dysfunction in viral cirrhotic patients: A data-mining analysis
URI https://api.istex.fr/ark:/67375/WNG-L14P985F-6/fulltext.pdf
https://cir.nii.ac.jp/crid/1571698601100499200
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1872-034X.2012.01076.x
https://www.ncbi.nlm.nih.gov/pubmed/22882558
https://www.proquest.com/docview/1324960093
https://www.proquest.com/docview/1348490674
Volume 43
WOSCitedRecordID wos000317304900011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVWIB
  databaseName: Wiley Online Library - Journals
  customDbUrl:
  eissn: 1872-034X
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017024
  issn: 1386-6346
  databaseCode: DRFUL
  dateStart: 20070101
  isFulltext: true
  titleUrlDefault: https://onlinelibrary.wiley.com
  providerName: Wiley-Blackwell
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELboLkJceD8CtDIS4pZq4_gVbhV06aGsVhUVe7Mc21EjShYlLYIDEj-B38gvYSZxI1aqUIW4RFESJ854JvONPZmPkBcAuZ3UzKayUnnKlc1SDV4jdcwF8C8zF7ztySbUYqFXq2IZ85_wX5ihPsQ44YaW0X-v0cBt2W0auVYsneV8hRlabBciCyV3AU9OGagxn5Dpm6P58eG4pqBmkeJWy1TmXG7m9Vx6rw1nNUW5w6Gtpq4vw6Ob8Lb3T_Pb__PN7pBbEaXSvUGt7pJroblHbryL6_D3yXekvPY0En7TuqM2DnPwFKd2KeBKitP4PWUpXVd0zFOi_luH3hQ1Ai6hmGV8Sl3dtidreByNlV67V3SPYv7qrx8_P_UsFtTGAioPyPF8__3rgzQSOaSOF1zC6HvupXWsqrKy4lXpikoAcPJC2dLLUGoudCjhpGDWA4JGWGYdL4PPxczl-UMyadZNeEwohIxV0KWUTgcOYKMQgvkilLZi2lnGEqIuRsy4WOUcyTZOzR_RDkjXoHQNStf00jVfE5KNLT8PlT6u0OZlrxRjA9t-xEw5JcyHxVtzmPFlocXcyIRsg9ZAj3CbCSxRpOVQrq8o4EOVkOcX-mTAvnHRxjZhfd6ZDBAvRJmzIv_bNVzzAnAHT8ijQRnHHjEGMZQQGgTT69yV380c7C-PcPfJP7d8Sm6ynj0EE52ekclZex62yXX35azu2h2ypVZ6J1rpby1_Nzk
linkProvider Wiley-Blackwell
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1fi9QwEA-6K-qLf0-tehpBfOvRpkma-nborSvuLctxh_sW0iTF4tmV7Z3og-BH8DP6SZxpc8WFQw7xpZS2adPJTOc3yXR-hDwHyG2lYiaWVZ7FPDdprMBrxJZZD_4lsd6Zjmwin8_VclksAh0Q_gvT14cYJtzQMrrvNRo4TkhvWrnKWZxkfIkpWmwHQotc7gCgHHPQKjEi49cHk6PZsKiQJ4HjVslYZlxuJvace68NbzVGwcOhy01dnwdIN_Ft56AmN__rq90iNwJOpbu9Yt0ml3xzh1zdDyvxd8l3JL12NFB-07qlJgy0dxQndykgS4oT-R1pKV1VdMhUou5bi_4UdQIuoZhnfExtvV5_WMHjaKj12r6kuxQzWH_9-Pmp47GgJpRQ2SJHk73DV9M4UDnElhdcwvg77qSxrKrSsuJVaYtKAHRyIjelk75UXChfwknBjAMMjcDMWF56l4nEZtk9MmpWjX9AKASNlVellFZ5DnCjEIK5wpemYsoaxiKSnw2ZtqHOOdJtHOs_4h2QrkbpapSu7qSrv0YkHVp-7mt9XKDNi04rhgZm_RFz5XKh38_f6FnKF4USEy0jsg1qAz3CbSqwSJGSfcG-ooBPVUSenSmUBgvHZRvT-NVpq1PAvBBnJkX2t2u44gUgDx6R-702Dj1iDKIoIRQIplO6C7-bnu4tDnD34T-3fEquTQ_3Z3r2dv7uEbnOOi4RTHt6TEYn61O_Ta7YLyd1u34SjPU3g3g6QQ
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELagiyou_BcWKBgJcUuVOLZjc6toQxHLalVRsTfL8Y9YUXar3RbBAYlH4Bl5EmYSN2KlClWISxQlceKMZzLf2JP5CHkOkNtJxWwmY1VmvLJFpsBrZI65AP4ld8HblmyiGo_VdKoniQ4I_4Xp6kP0E25oGe33Gg08nPi4buWqYlle8immaLEdCC0quQOAcsCFlmClg73D-mjULypUeeK4VTKTJZfriT0X3mvNWw1Q8HDo6nw2uwiQruPb1kHVN__rq90iNxJOpbudYt0mV8L8Dtl8l1bi75LvSHrtaaL8prMVtWmgg6c4uUsBWVKcyG9JS-ki0j5TifpvK_SnqBNwCcU842PqZsvlxwU8jqZar6uXdJdiBuuvHz8_tzwW1KYSKvfIUb3__tVBlqgcMsc1lzD-nntpHYuxaCKPjdNRAHTyorKNl6FRXKjQwEnBrAcMjcDMOt4EX4rcleUW2Zgv5uEBoRA0xqAaKZ0KHOCGFoJ5HRobmXKWsSGpzofMuFTnHOk2js0f8Q5I16B0DUrXtNI1X4ek6FuedLU-LtHmRasVfQO7_IS5cpUwH8avzajgE61EbeSQbIPaQI9wWwgsUqRkV7BPa_hUDcmzc4UyYOG4bGPnYXG2MgVgXogzc13-7RquuAbkwYfkfqeNfY8YgyhKCAWCaZXu0u9mDvYnh7j78J9bPiWbk73ajN6M3z4i11lLJYJZT4_JxunyLGyTa-7L6Wy1fJJs9Te2Fjm8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lipid+profile+is+associated+with+the+incidence+of+cognitive+dysfunction+in+viral+cirrhotic+patients%3A+A+data-mining+analysis&rft.jtitle=Hepatology+research&rft.au=Taniguchi%2C+Eitaro&rft.au=Kawaguchi%2C+Takumi&rft.au=Sakata%2C+Masahiro&rft.au=Itou%2C+Minoru&rft.date=2013-04-01&rft.pub=Blackwell+Publishing+Asia&rft.issn=1386-6346&rft.eissn=1872-034X&rft.volume=43&rft.issue=4&rft.spage=418&rft.epage=424&rft_id=info:doi/10.1111%2Fj.1872-034X.2012.01076.x&rft.externalDBID=n%2Fa&rft.externalDocID=ark_67375_WNG_L14P985F_6
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1386-6346&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1386-6346&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1386-6346&client=summon