Usefulness of 18F-FDOPA PET for the management of primary brain tumors: a systematic review of the literature

Contrast-enhanced magnetic resonance imaging is currently the standard of care in the management of primary brain tumors, although certain limitations remain. Metabolic imaging has proven useful for an increasing number of indications in oncology over the past few years, most particularly 18 F-FDG P...

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Vydáno v:Cancer imaging Ročník 20; číslo 1; s. 1 - 13
Hlavní autoři: Somme, François, Bender, Laura, Namer, Izzie Jacques, Noël, Georges, Bund, Caroline
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 06.10.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Accuracy
Amino acids
Bioengineering
Brain
Brain cancer
Brain tumors
Cable television broadcasting industry
Cancer
Cancer Research
Evaluation
F-DOPA
Fluorine isotopes
Glioma
Gliomas
Imaging
Imaging techniques
Life Sciences
Literature reviews
Magnetic resonance imaging
Management
Medical imaging
Medicine
Medicine & Public Health
Metabolism
Neurons and Cognition
Nuclear Medicine
Oncology
Positron emission tomography
Primary brain tumor
Radioactive tracers
Radioisotopes
Radiology
Recurrence (Disease)
Review
Surgery
Systematic review
Tumors
United States
Systematic review
Glioma
Primary brain tumor
F-DOPA
ISSN:1470-7330, 1740-5025, 1470-7330
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Shrnutí:Contrast-enhanced magnetic resonance imaging is currently the standard of care in the management of primary brain tumors, although certain limitations remain. Metabolic imaging has proven useful for an increasing number of indications in oncology over the past few years, most particularly 18 F-FDG PET/CT. In neuro-oncology, 18 F-FDG was insufficient to clearly evaluate brain tumors. Amino-acid radiotracers such as 18 F-FDOPA were then evaluated in the management of brain diseases, notably tumoral diseases. Even though European guidelines on the use of amino-acid PET in gliomas have been published, it is crucial that future studies standardize acquisition and interpretation parameters. The aim of this article was to systematically review the potential effect of this metabolic imaging technique in numerous steps of the disease: primary and recurrence diagnosis, grading, local and systemic treatment assessment, and prognosis. A total of 41 articles were included and analyzed in this review. It appears that 18 F-FDOPA PET holds promise as an effective additional tool in the management of gliomas. More consistent prospective studies are still needed.
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PMCID: PMC7541204
ISSN:1470-7330
1740-5025
1470-7330
DOI:10.1186/s40644-020-00348-5