A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma

Pancreatic cancer expression profiles largely reflect a classical or basal-like phenotype. The extent to which these profiles vary within a patient is unknown. We integrated evolutionary analysis and expression profiling in multiregion-sampled metastatic pancreatic cancers, finding that squamous fea...

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Bibliographic Details
Published in:	Nature cancer Vol. 1; no. 1; pp. 59 - 74
Main Authors:	Hayashi, Akimasa, Fan, Jun, Chen, Ruoyao, Ho, Yu-jui, Makohon-Moore, Alvin P., Lecomte, Nicolas, Zhong, Yi, Hong, Jungeui, Huang, Jinlong, Sakamoto, Hitomi, Attiyeh, Marc A., Kohutek, Zachary A., Zhang, Lance, Boumiza, Aida, Kappagantula, Rajya, Baez, Priscilla, Bai, Jessica, Lisi, Marta, Chadalavada, Kalyani, Melchor, Jerry P., Wong, Winston, Nanjangud, Gouri J., Basturk, Olca, O’Reilly, Eileen M., Klimstra, David S., Hruban, Ralph H., Wood, Laura D., Overholtzer, Michael, Iacobuzio-Donahue, Christine A.
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.01.2020
Subjects:	Autopsies Carcinoma, Pancreatic Ductal - genetics Carcinoma, Squamous Cell - genetics Chromatin Evolution & development Genomes Humans Labeling Medical prognosis Metastasis Morphology Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - genetics Patients Phylogeny Taxonomy
ISSN:	2662-1347, 2662-1347
Online Access:	Get full text
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