Unique Growth Pattern Presentation of a Papillary Renal Cell Carcinoma

Papillary renal cell carcinoma (PRCC) is defined by the WHO 2022 classification as a malignant tumor derived from the renal tubular epithelium. However, the WHO 2016 classification subdivided PRCC into two types, with type 1 PRCC showing papillae covered by a single layer of neoplastic cells, and ty...

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Bibliographic Details
Published in:Diagnostics (Basel) Vol. 12; no. 8; p. 1904
Main Authors: Harich, Octavia Oana, Olteanu, Gheorghe-Emilian, Mihai, Ioana Maria, Benta, Marius, Isabella, Gavriliuc Oana, Virgil, Paunescu, Bojin, Florina Maria
Format: Journal Article
Language:English
Published: Basel MDPI AG 01.08.2022
MDPI
Subjects:
Biopsy
Carcinoma, Renal cell
Case Report
Case studies
Development and progression
Diagnosis
Emergency medical care
growth pattern
Hematuria
Histology
IHC
Kidney cancer
Kinases
NGS
papillary renal cell carcinoma
Pathology
Tumors
Romania
United States > US
ISSN:2075-4418, 2075-4418
Online Access:Get full text
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Summary:Papillary renal cell carcinoma (PRCC) is defined by the WHO 2022 classification as a malignant tumor derived from the renal tubular epithelium. However, the WHO 2016 classification subdivided PRCC into two types, with type 1 PRCC showing papillae covered by a single layer of neoplastic cells, and type II PRCC, which can show multiple types of histologies and is more aggressive. The WHO 2022 classification eliminated the subcategorization of PRCC. Here, we present a histopathological case study with a 4-year follow-up diagnosed in 2018 as type I PRCC (WHO 2016) with intra-pyelocalyceal growth pattern in a 59-year-old male patient with a history of Type II diabetes mellitus, left-sided renal–ureteral lithiasis, and benign hypertrophy of the prostate. Microscopically the tumor was composed of small cuboidal cells with inconspicuous nucleoli, arranged on a single layer of tubulo-papillary cores, and scant, foamy macrophages. The tumor had a non-infiltrative, expansive pyelocalyceal growth pattern. Immunohistochemically (IHC), the tumor cells were CK7-intense and diffusely positive, and stained granular for AMACR. Next-generation sequencing (NGS) was performed for the tumor and the normal adjacent tissue for in-depth pathological characterization. To our knowledge, this is the first reported case where a PRCC displays this unique intra-pyelocalyceal growth pattern, mimicking a urothelial cell carcinoma of the renal pelvis system.
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These authors contributed equally to this work.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12081904