Beyond Allergies—Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis

Mast cells (MCs) are an important part of the immune system, responding both to pathogens and toxins, but they also play an important role in allergic diseases, where recent data show that non-IgE-mediated activation is also of relevance, especially in chronic urticaria (CU) and atopic dermatitis (A...

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Published in:Cells (Basel, Switzerland) Vol. 13; no. 3; p. 220
Main Authors: Lerner, Liron, Babina, Magda, Zuberbier, Torsten, Stevanovic, Katarina
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01.01.2024
Subjects:
Allergic diseases
Allergies
Atopic dermatitis
Care and treatment
Chronic Urticaria - drug therapy
Degranulation
Dermatitis
Dermatitis, Atopic - drug therapy
Dermatitis, Atopic - metabolism
Drugs
G protein-coupled receptors
Health care
Humans
Hypersensitivity - metabolism
Immune system
Immunoglobulin E
Investigations
Mast cells
Mast Cells - metabolism
MRGPRX2
Nerve Tissue Proteins - metabolism
Pathogenesis
Pathophysiology
Physiological aspects
Proteins
Receptors, G-Protein-Coupled - metabolism
Receptors, Neuropeptide - metabolism
Skin diseases
skin mast cells
Therapeutic targets
Urticaria
Germany
skin mast cells
atopic dermatitis
MRGPRX2
urticaria
ISSN:2073-4409, 2073-4409
Online Access:Get full text
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Abstract Mast cells (MCs) are an important part of the immune system, responding both to pathogens and toxins, but they also play an important role in allergic diseases, where recent data show that non-IgE-mediated activation is also of relevance, especially in chronic urticaria (CU) and atopic dermatitis (AD). Skin MCs express Mas-related G-protein-coupled receptor X2 (MRGPRX2), a key protein in non-IgE-dependent MC degranulation, and its overactivity is one of the triggering factors for the above-mentioned diseases, making MRGPRX2 a potential therapeutic target. Reviewing the latest literature revealed our need to focus on the discovery of MRGPRX2 activators as well as the ongoing vast research towards finding specific MRGPRX2 inhibitors for potential therapeutic approaches. Most of these studies are in their preliminary stages, with one drug currently being investigated in a clinical trial. Future studies and improved model systems are needed to verify whether any of these inhibitors may have the potential to be the next therapeutic treatment for CU, AD, and other pseudo-allergic reactions.
AbstractList Mast cells (MCs) are an important part of the immune system, responding both to pathogens and toxins, but they also play an important role in allergic diseases, where recent data show that non-IgE-mediated activation is also of relevance, especially in chronic urticaria (CU) and atopic dermatitis (AD). Skin MCs express Mas-related G-protein-coupled receptor X2 (MRGPRX2), a key protein in non-IgE-dependent MC degranulation, and its overactivity is one of the triggering factors for the above-mentioned diseases, making MRGPRX2 a potential therapeutic target. Reviewing the latest literature revealed our need to focus on the discovery of MRGPRX2 activators as well as the ongoing vast research towards finding specific MRGPRX2 inhibitors for potential therapeutic approaches. Most of these studies are in their preliminary stages, with one drug currently being investigated in a clinical trial. Future studies and improved model systems are needed to verify whether any of these inhibitors may have the potential to be the next therapeutic treatment for CU, AD, and other pseudo-allergic reactions.
Mast cells (MCs) are an important part of the immune system, responding both to pathogens and toxins, but they also play an important role in allergic diseases, where recent data show that non-IgE-mediated activation is also of relevance, especially in chronic urticaria (CU) and atopic dermatitis (AD). Skin MCs express Mas-related G-protein-coupled receptor X2 (MRGPRX2), a key protein in non-IgE-dependent MC degranulation, and its overactivity is one of the triggering factors for the above-mentioned diseases, making MRGPRX2 a potential therapeutic target. Reviewing the latest literature revealed our need to focus on the discovery of MRGPRX2 activators as well as the ongoing vast research towards finding specific MRGPRX2 inhibitors for potential therapeutic approaches. Most of these studies are in their preliminary stages, with one drug currently being investigated in a clinical trial. Future studies and improved model systems are needed to verify whether any of these inhibitors may have the potential to be the next therapeutic treatment for CU, AD, and other pseudo-allergic reactions.Mast cells (MCs) are an important part of the immune system, responding both to pathogens and toxins, but they also play an important role in allergic diseases, where recent data show that non-IgE-mediated activation is also of relevance, especially in chronic urticaria (CU) and atopic dermatitis (AD). Skin MCs express Mas-related G-protein-coupled receptor X2 (MRGPRX2), a key protein in non-IgE-dependent MC degranulation, and its overactivity is one of the triggering factors for the above-mentioned diseases, making MRGPRX2 a potential therapeutic target. Reviewing the latest literature revealed our need to focus on the discovery of MRGPRX2 activators as well as the ongoing vast research towards finding specific MRGPRX2 inhibitors for potential therapeutic approaches. Most of these studies are in their preliminary stages, with one drug currently being investigated in a clinical trial. Future studies and improved model systems are needed to verify whether any of these inhibitors may have the potential to be the next therapeutic treatment for CU, AD, and other pseudo-allergic reactions.
Audience Academic
Author Stevanovic, Katarina
Zuberbier, Torsten
Lerner, Liron
Babina, Magda
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SSID ssj0000816105
Score 2.3354385
Snippet Mast cells (MCs) are an important part of the immune system, responding both to pathogens and toxins, but they also play an important role in allergic...
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StartPage 220
SubjectTerms Allergic diseases
Allergies
Atopic dermatitis
Care and treatment
Chronic Urticaria - drug therapy
Degranulation
Dermatitis
Dermatitis, Atopic - drug therapy
Dermatitis, Atopic - metabolism
Drugs
G protein-coupled receptors
Health care
Humans
Hypersensitivity - metabolism
Immune system
Immunoglobulin E
Investigations
Mast cells
Mast Cells - metabolism
MRGPRX2
Nerve Tissue Proteins - metabolism
Pathogenesis
Pathophysiology
Physiological aspects
Proteins
Receptors, G-Protein-Coupled - metabolism
Receptors, Neuropeptide - metabolism
Skin diseases
skin mast cells
Therapeutic targets
Urticaria
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Title Beyond Allergies—Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis
URI https://www.ncbi.nlm.nih.gov/pubmed/38334612
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Volume 13
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