AID is required for c-myc/IgH chromosome translocations in vivo

Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class swi...

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Bibliographic Details
Published in:Cell Vol. 118; no. 4; p. 431
Main Authors: Ramiro, Almudena R, Jankovic, Mila, Eisenreich, Thomas, Difilippantonio, Simone, Chen-Kiang, Selina, Muramatsu, Masamichi, Honjo, Tasuku, Nussenzweig, André, Nussenzweig, Michel C
Format: Journal Article
Language:English
Published: United States 20.08.2004
Subjects:
Animals
B-Lymphocytes - metabolism
Cell Separation
Chromosomes - ultrastructure
Cytidine Deaminase - genetics
Cytidine Deaminase - metabolism
Cytidine Deaminase - physiology
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Immunoglobulin G - chemistry
Immunoglobulins - chemistry
Interleukin-6 - metabolism
Mice
Mice, Inbred BALB C
Mice, Transgenic
Models, Genetic
Polymerase Chain Reaction
Protein Transport
Proto-Oncogene Proteins c-myc - metabolism
Time Factors
Translocation, Genetic
ISSN:0092-8674
Online Access:Get more information
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Summary:Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class switch recombination (CSR). However, a direct link between CSR and chromosome translocations has not been established. We have examined c-myc/IgH translocations in IL6 transgenic mice that are mutant for activation induced cytidine deaminase (AID), the enzyme that initiates CSR. Here we report that AID is essential for the c-myc/IgH chromosome translocations induced by IL6.
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ISSN:0092-8674
DOI:10.1016/j.cell.2004.08.006