Protective Effect of Quercetin 3-O-Glucuronide against Cisplatin Cytotoxicity in Renal Tubular Cells

Quercetin, a flavonoid with promising therapeutic potential, has been shown to protect from cisplatin nephrotoxicity in rats following intraperitoneal injection, but its low bioavailability curtails its prospective clinical utility in oral therapy. We recently developed a micellar formulation (P-que...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Jg. 27; H. 4; S. 1319
Hauptverfasser:	Muñoz-Reyes, Daniel, Casanova, Alfredo G., González-Paramás, Ana María, Martín, Ángel, Santos-Buelga, Celestino, Morales, Ana I., López-Hernández, Francisco J., Prieto, Marta
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 15.02.2022 MDPI
Schlagworte:	Animals Apoptosis Bioavailability Cell division Cell Line Cells, Cultured Chemotherapy Chromatography, High Pressure Liquid cisplatin Cisplatin - adverse effects Cisplatin - pharmacology Creatinine cytoprotection Cytoprotection - drug effects Cytotoxicity Drug dosages Epithelial Cells - drug effects Flavonoids Glomerular Filtration Rate Kidney Function Tests - methods Kidney Tubules - cytology Kidney Tubules - drug effects Kinases Metabolites nephrotoxicity Oral administration Plasma Protective Agents - pharmacology quercetin Quercetin - analogs & derivatives Quercetin - pharmacology quercetin 3-O-glucuronide Rats Small intestine Urine quercetin quercetin 3-O-glucuronide cytoprotection nephrotoxicity cisplatin
ISSN:	1420-3049, 1420-3049
Online-Zugang:	Volltext
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