Protective Effect of Quercetin 3-O-Glucuronide against Cisplatin Cytotoxicity in Renal Tubular Cells
Quercetin, a flavonoid with promising therapeutic potential, has been shown to protect from cisplatin nephrotoxicity in rats following intraperitoneal injection, but its low bioavailability curtails its prospective clinical utility in oral therapy. We recently developed a micellar formulation (P-que...
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| Published in: | Molecules (Basel, Switzerland) Vol. 27; no. 4; p. 1319 |
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| Abstract | Quercetin, a flavonoid with promising therapeutic potential, has been shown to protect from cisplatin nephrotoxicity in rats following intraperitoneal injection, but its low bioavailability curtails its prospective clinical utility in oral therapy. We recently developed a micellar formulation (P-quercetin) with enhanced solubility and bioavailability, and identical nephroprotective properties. As a first aim, we herein evaluated the oral treatment with P-quercetin in rats, which displayed no nephroprotection. In order to unravel this discrepancy, quercetin and its main metabolites were measured by HPLC in the blood and urine after intraperitoneal and oral administrations. Whilst quercetin was absorbed similarly, the profile of its metabolites was different, which led us to hypothesize that nephroprotection might be exerted in vivo by a metabolic derivate. Consequently, we then aimed to evaluate the cytoprotective capacity of quercetin and its main metabolites (quercetin 3-O-glucoside, rutin, tamarixetin, isorhamnetin and quercetin 3-O-glucuronide) against cisplatin toxicity, in HK-2 and NRK-52E tubular cell lines. Cells were incubated for 6 h with quercetin, its metabolites or vehicle (pretreatment), and subsequently 18 h in cotreatment with 10–300 μM cisplatin. Immediately after treatment, cell cultures were subject to the MTT technique as an index of cytotoxicity and photographed under light microscopy for phenotypic assessment. Quercetin afforded no direct cytoprotection and quercetin-3-O-glucuronide was the only metabolite partially preventing the effect of cisplatin in cultured tubule cells. Our results identify a metabolic derivative of quercetin contributing to its nephroprotection and prompt to further explore exogenous quercetin-3-O-glucuronide in the prophylaxis of tubular nephrotoxicity. |
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| AbstractList | Quercetin, a flavonoid with promising therapeutic potential, has been shown to protect from cisplatin nephrotoxicity in rats following intraperitoneal injection, but its low bioavailability curtails its prospective clinical utility in oral therapy. We recently developed a micellar formulation (P-quercetin) with enhanced solubility and bioavailability, and identical nephroprotective properties. As a first aim, we herein evaluated the oral treatment with P-quercetin in rats, which displayed no nephroprotection. In order to unravel this discrepancy, quercetin and its main metabolites were measured by HPLC in the blood and urine after intraperitoneal and oral administrations. Whilst quercetin was absorbed similarly, the profile of its metabolites was different, which led us to hypothesize that nephroprotection might be exerted in vivo by a metabolic derivate. Consequently, we then aimed to evaluate the cytoprotective capacity of quercetin and its main metabolites (quercetin 3-O-glucoside, rutin, tamarixetin, isorhamnetin and quercetin 3-O-glucuronide) against cisplatin toxicity, in HK-2 and NRK-52E tubular cell lines. Cells were incubated for 6 h with quercetin, its metabolites or vehicle (pretreatment), and subsequently 18 h in cotreatment with 10–300 μM cisplatin. Immediately after treatment, cell cultures were subject to the MTT technique as an index of cytotoxicity and photographed under light microscopy for phenotypic assessment. Quercetin afforded no direct cytoprotection and quercetin-3-O-glucuronide was the only metabolite partially preventing the effect of cisplatin in cultured tubule cells. Our results identify a metabolic derivative of quercetin contributing to its nephroprotection and prompt to further explore exogenous quercetin-3-O-glucuronide in the prophylaxis of tubular nephrotoxicity. Quercetin, a flavonoid with promising therapeutic potential, has been shown to protect from cisplatin nephrotoxicity in rats following intraperitoneal injection, but its low bioavailability curtails its prospective clinical utility in oral therapy. We recently developed a micellar formulation (P-quercetin) with enhanced solubility and bioavailability, and identical nephroprotective properties. As a first aim, we herein evaluated the oral treatment with P-quercetin in rats, which displayed no nephroprotection. In order to unravel this discrepancy, quercetin and its main metabolites were measured by HPLC in the blood and urine after intraperitoneal and oral administrations. Whilst quercetin was absorbed similarly, the profile of its metabolites was different, which led us to hypothesize that nephroprotection might be exerted in vivo by a metabolic derivate. Consequently, we then aimed to evaluate the cytoprotective capacity of quercetin and its main metabolites (quercetin 3- -glucoside, rutin, tamarixetin, isorhamnetin and quercetin 3- -glucuronide) against cisplatin toxicity, in HK-2 and NRK-52E tubular cell lines. Cells were incubated for 6 h with quercetin, its metabolites or vehicle (pretreatment), and subsequently 18 h in cotreatment with 10-300 μM cisplatin. Immediately after treatment, cell cultures were subject to the MTT technique as an index of cytotoxicity and photographed under light microscopy for phenotypic assessment. Quercetin afforded no direct cytoprotection and quercetin-3- -glucuronide was the only metabolite partially preventing the effect of cisplatin in cultured tubule cells. Our results identify a metabolic derivative of quercetin contributing to its nephroprotection and prompt to further explore exogenous quercetin-3- -glucuronide in the prophylaxis of tubular nephrotoxicity. Quercetin, a flavonoid with promising therapeutic potential, has been shown to protect from cisplatin nephrotoxicity in rats following intraperitoneal injection, but its low bioavailability curtails its prospective clinical utility in oral therapy. We recently developed a micellar formulation (P-quercetin) with enhanced solubility and bioavailability, and identical nephroprotective properties. As a first aim, we herein evaluated the oral treatment with P-quercetin in rats, which displayed no nephroprotection. In order to unravel this discrepancy, quercetin and its main metabolites were measured by HPLC in the blood and urine after intraperitoneal and oral administrations. Whilst quercetin was absorbed similarly, the profile of its metabolites was different, which led us to hypothesize that nephroprotection might be exerted in vivo by a metabolic derivate. Consequently, we then aimed to evaluate the cytoprotective capacity of quercetin and its main metabolites (quercetin 3-O-glucoside, rutin, tamarixetin, isorhamnetin and quercetin 3-O-glucuronide) against cisplatin toxicity, in HK-2 and NRK-52E tubular cell lines. Cells were incubated for 6 h with quercetin, its metabolites or vehicle (pretreatment), and subsequently 18 h in cotreatment with 10-300 μM cisplatin. Immediately after treatment, cell cultures were subject to the MTT technique as an index of cytotoxicity and photographed under light microscopy for phenotypic assessment. Quercetin afforded no direct cytoprotection and quercetin-3-O-glucuronide was the only metabolite partially preventing the effect of cisplatin in cultured tubule cells. Our results identify a metabolic derivative of quercetin contributing to its nephroprotection and prompt to further explore exogenous quercetin-3-O-glucuronide in the prophylaxis of tubular nephrotoxicity.Quercetin, a flavonoid with promising therapeutic potential, has been shown to protect from cisplatin nephrotoxicity in rats following intraperitoneal injection, but its low bioavailability curtails its prospective clinical utility in oral therapy. We recently developed a micellar formulation (P-quercetin) with enhanced solubility and bioavailability, and identical nephroprotective properties. As a first aim, we herein evaluated the oral treatment with P-quercetin in rats, which displayed no nephroprotection. In order to unravel this discrepancy, quercetin and its main metabolites were measured by HPLC in the blood and urine after intraperitoneal and oral administrations. Whilst quercetin was absorbed similarly, the profile of its metabolites was different, which led us to hypothesize that nephroprotection might be exerted in vivo by a metabolic derivate. Consequently, we then aimed to evaluate the cytoprotective capacity of quercetin and its main metabolites (quercetin 3-O-glucoside, rutin, tamarixetin, isorhamnetin and quercetin 3-O-glucuronide) against cisplatin toxicity, in HK-2 and NRK-52E tubular cell lines. Cells were incubated for 6 h with quercetin, its metabolites or vehicle (pretreatment), and subsequently 18 h in cotreatment with 10-300 μM cisplatin. Immediately after treatment, cell cultures were subject to the MTT technique as an index of cytotoxicity and photographed under light microscopy for phenotypic assessment. Quercetin afforded no direct cytoprotection and quercetin-3-O-glucuronide was the only metabolite partially preventing the effect of cisplatin in cultured tubule cells. Our results identify a metabolic derivative of quercetin contributing to its nephroprotection and prompt to further explore exogenous quercetin-3-O-glucuronide in the prophylaxis of tubular nephrotoxicity. |
| Author | Muñoz-Reyes, Daniel Martín, Ángel Casanova, Alfredo G. González-Paramás, Ana María Morales, Ana I. Santos-Buelga, Celestino López-Hernández, Francisco J. Prieto, Marta |
| AuthorAffiliation | 4 Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain 5 National Network for Kidney Research REDINREN, RD016/0009/0025, Instituto de Salud Carlos III, 28029 Madrid, Spain 6 Polyphenols Research Group (GIP-USAL), Nutrition and Bromatology Unit, Faculty of Pharmacy, Universidad de Salamanca, 37007 Salamanca, Spain; paramas@usal.es (A.M.G.-P.); csb@usal.es (C.S.-B.) 3 Group of Translational Research on Renal and Cardiovascular Diseases (TRECARD), 37007 Salamanca, Spain 1 Toxicology Unit, Universidad de Salamanca, 37007 Salamanca, Spain; danimr@usal.es (D.M.-R.); alfredogcp@usal.es (A.G.C.); amorales@usal.es (A.I.M.); martapv@usal.es (M.P.) 2 Department of Physiology and Pharmacology, Universidad de Salamanca, 37007 Salamanca, Spain 7 High Pressure Processes Group, BioEcoUVa, Bioeconomy Research Institute, Department of Chemical Engineering and Environmental Technology, Universidad de Valladolid, 47011 Valladolid, Spain; mamaan@iq.uva.es |
| AuthorAffiliation_xml | – name: 3 Group of Translational Research on Renal and Cardiovascular Diseases (TRECARD), 37007 Salamanca, Spain – name: 2 Department of Physiology and Pharmacology, Universidad de Salamanca, 37007 Salamanca, Spain – name: 1 Toxicology Unit, Universidad de Salamanca, 37007 Salamanca, Spain; danimr@usal.es (D.M.-R.); alfredogcp@usal.es (A.G.C.); amorales@usal.es (A.I.M.); martapv@usal.es (M.P.) – name: 4 Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain – name: 6 Polyphenols Research Group (GIP-USAL), Nutrition and Bromatology Unit, Faculty of Pharmacy, Universidad de Salamanca, 37007 Salamanca, Spain; paramas@usal.es (A.M.G.-P.); csb@usal.es (C.S.-B.) – name: 7 High Pressure Processes Group, BioEcoUVa, Bioeconomy Research Institute, Department of Chemical Engineering and Environmental Technology, Universidad de Valladolid, 47011 Valladolid, Spain; mamaan@iq.uva.es – name: 5 National Network for Kidney Research REDINREN, RD016/0009/0025, Instituto de Salud Carlos III, 28029 Madrid, Spain |
| Author_xml | – sequence: 1 givenname: Daniel orcidid: 0000-0001-8464-1996 surname: Muñoz-Reyes fullname: Muñoz-Reyes, Daniel – sequence: 2 givenname: Alfredo G. orcidid: 0000-0002-0725-6637 surname: Casanova fullname: Casanova, Alfredo G. – sequence: 3 givenname: Ana María orcidid: 0000-0001-5477-0703 surname: González-Paramás fullname: González-Paramás, Ana María – sequence: 4 givenname: Ángel surname: Martín fullname: Martín, Ángel – sequence: 5 givenname: Celestino orcidid: 0000-0001-6592-5299 surname: Santos-Buelga fullname: Santos-Buelga, Celestino – sequence: 6 givenname: Ana I. orcidid: 0000-0001-6836-6138 surname: Morales fullname: Morales, Ana I. – sequence: 7 givenname: Francisco J. orcidid: 0000-0001-7778-7495 surname: López-Hernández fullname: López-Hernández, Francisco J. – sequence: 8 givenname: Marta orcidid: 0000-0002-2540-4461 surname: Prieto fullname: Prieto, Marta |
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| Cites_doi | 10.1038/nrneph.2010.16 10.1038/sj.ki.5002786 10.1079/BJN20061809 10.1002/mnfr.201100378 10.1080/10408390600846291 10.1016/j.ejphar.2014.07.025 10.1111/1541-4337.12342 10.1002/jsfa.5697 10.1016/j.neurobiolaging.2016.12.024 10.1093/ndt/12.12.2478 10.1093/ndt/gfq840 10.1093/toxsci/kfr098 10.3390/antiox10060909 10.1093/ndt/gfr195 10.1007/s40620-017-0392-z 10.2174/0929867325666180706104829 10.2174/1568011033353470 10.1186/cc2872 10.1039/c2fo10268d 10.1016/j.bcp.2011.01.004 10.1007/s002800100318 10.1371/journal.pone.0032673 10.1186/cc5713 10.1124/jpet.102.040220 10.1021/ie5001136 10.1016/j.phrs.2014.07.005 10.1080/10715760600823128 10.1002/jsfa.8197 10.3390/ijms22020729 10.1038/srep35460 10.1097/MAJ.0b013e31812dfe1e 10.1016/j.bcp.2017.08.017 10.1016/j.bbrc.2018.09.018 10.1016/j.tifs.2016.07.004 10.3109/10408444.2011.602662 10.3390/ijms18030531 10.1258/000456307779595940 10.1016/j.cbi.2011.07.002 10.12659/MSM.909259 10.1039/C4FO00413B 10.1016/j.fct.2017.06.047 10.1124/dmd.116.069575 10.1038/sj.bjp.0704064 |
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| Keywords | quercetin quercetin 3-O-glucuronide cytoprotection nephrotoxicity cisplatin |
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| References | Baral (ref_30) 2017; 52 Lash (ref_24) 2002; 303 Deiana (ref_32) 2011; 193 Gluba (ref_9) 2010; 6 Wang (ref_10) 2016; 56 Nemeth (ref_27) 2007; 47 Vanholder (ref_20) 2011; 26 Manohar (ref_2) 2018; 31 Morales (ref_3) 2011; 26 Steffen (ref_35) 2021; 146 Yang (ref_36) 2016; 6 Kuhlmann (ref_4) 1997; 12 DeHaan (ref_8) 2001; 48 ref_12 Duarte (ref_42) 2006; 40 Russo (ref_11) 2014; 5 (ref_13) 2019; 26 Almeida (ref_26) 2018; 17 Menendez (ref_38) 2011; 55 Mullen (ref_44) 2006; 96 Duarte (ref_37) 2012; 92 Chen (ref_31) 2003; 3 ref_16 Perez (ref_39) 2014; 89 Cueva (ref_45) 2017; 97 Yao (ref_1) 2007; 334 Prieto (ref_15) 2017; 107 Pabla (ref_6) 2008; 73 Khwaja (ref_19) 2012; 120 Asai (ref_33) 2018; 504 Morales (ref_22) 2011; 41 Galindo (ref_25) 2012; 3 Piedrafita (ref_5) 2011; 122 Diskin (ref_21) 2007; 44 ref_23 Semenova (ref_28) 2017; 145 ref_40 Mehta (ref_18) 2007; 11 Iwamura (ref_34) 2016; 44 Dasari (ref_7) 2014; 740 Bellomo (ref_17) 2004; 8 Yang (ref_14) 2018; 24 Wong (ref_29) 2011; 81 Duarte (ref_41) 2001; 133 Fraile (ref_43) 2014; 53 |
| References_xml | – volume: 6 start-page: 224 year: 2010 ident: ref_9 article-title: The Role of Toll-like Receptors in Renal Diseases publication-title: Nat. Rev. Nephrol. doi: 10.1038/nrneph.2010.16 – volume: 73 start-page: 994 year: 2008 ident: ref_6 article-title: Cisplatin Nephrotoxicity: Mechanisms and Renoprotective Strategies publication-title: Kidney Int. doi: 10.1038/sj.ki.5002786 – volume: 96 start-page: 107 year: 2006 ident: ref_44 article-title: Absorption, Excretion and Metabolite Profiling of Methyl-, Glucuronyl-, Glucosyl- and Sulpho-Conjugates of Quercetin in Human Plasma and Urine after Ingestion of Onions publication-title: Br. J. Nutr. doi: 10.1079/BJN20061809 – volume: 55 start-page: 1780 year: 2011 ident: ref_38 article-title: Vascular Deconjugation of Quercetin Glucuronide: The Flavonoid Paradox Revealed? publication-title: Mol. Nutr. Food Res. doi: 10.1002/mnfr.201100378 – volume: 47 start-page: 397 year: 2007 ident: ref_27 article-title: Food Content, Processing, Absorption and Metabolism of Onion Flavonoids publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408390600846291 – volume: 120 start-page: c179 year: 2012 ident: ref_19 article-title: KDIGO Clinical Practice Guidelines for Acute Kidney Injury publication-title: Nephron – volume: 740 start-page: 364 year: 2014 ident: ref_7 article-title: Cisplatin in Cancer Therapy: Molecular Mechanisms of Action publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2014.07.025 – volume: 17 start-page: 714 year: 2018 ident: ref_26 article-title: Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation: Variability in Quercetin Bioavailability publication-title: Compr. Rev. Food Sci. Food Saf. doi: 10.1111/1541-4337.12342 – volume: 92 start-page: 1822 year: 2012 ident: ref_37 article-title: The Flavonoid Paradox: Conjugation and Deconjugation as Key Steps for the Biological Activity of Flavonoids: The Flavonoid Paradox publication-title: J. Sci. Food Agric. doi: 10.1002/jsfa.5697 – volume: 146 start-page: 1009 year: 2021 ident: ref_35 article-title: Analgesic Drug Therapy in Kidney Patients publication-title: Dtsch. Med. Wochenschr. – volume: 52 start-page: 39 year: 2017 ident: ref_30 article-title: Quercetin-3-O-Glucuronide Promotes the Proliferation and Migration of Neural Stem Cells publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2016.12.024 – volume: 12 start-page: 2478 year: 1997 ident: ref_4 article-title: Insights into Potential Cellular Mechanisms of Cisplatin Nephrotoxicity and Their Clinical Application publication-title: Nephrol. Dial. Transplant. doi: 10.1093/ndt/12.12.2478 – volume: 26 start-page: 3211 year: 2011 ident: ref_20 article-title: Serum Urea Concentration Is Probably Not Related to Outcome in ICU Patients with AKI and Renal Replacement Therapy publication-title: Nephrol. Dial. Transplant. doi: 10.1093/ndt/gfq840 – volume: 122 start-page: 73 year: 2011 ident: ref_5 article-title: Necrotic Concentrations of Cisplatin Activate the Apoptotic Machinery but Inhibit Effector Caspases and Interfere with the Execution of Apoptosis publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfr098 – ident: ref_12 doi: 10.3390/antiox10060909 – volume: 26 start-page: 3484 year: 2011 ident: ref_3 article-title: Quercetin Reduces Cisplatin Nephrotoxicity in Rats without Compromising Its Anti-Tumour Activity publication-title: Nephrol. Dial. Transplant. doi: 10.1093/ndt/gfr195 – volume: 31 start-page: 15 year: 2018 ident: ref_2 article-title: Cisplatin Nephrotoxicity: A Review of the Literature publication-title: J. Nephrol. doi: 10.1007/s40620-017-0392-z – volume: 26 start-page: 6976 year: 2019 ident: ref_13 article-title: The Mechanisms Behind the Biological Activity of Flavonoids publication-title: Curr. Med. Chem. doi: 10.2174/0929867325666180706104829 – volume: 3 start-page: 139 year: 2003 ident: ref_31 article-title: Glucuronides in Anti-Cancer Therapy publication-title: Curr. Med. Chem.-Anti-Cancer Agents doi: 10.2174/1568011033353470 – volume: 8 start-page: R204 year: 2004 ident: ref_17 article-title: Acute Renal Failure—Definition, Outcome Measures, Animal Models, Fluid Therapy and Information Technology Needs: The Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group publication-title: Crit Care doi: 10.1186/cc2872 – volume: 3 start-page: 643 year: 2012 ident: ref_25 article-title: Different Cardiovascular Protective Effects of Quercetin Administered Orally or Intraperitoneally in Spontaneously Hypertensive Rats publication-title: Food Funct. doi: 10.1039/c2fo10268d – volume: 81 start-page: 942 year: 2011 ident: ref_29 article-title: Flavonoid Conjugates Interact with Organic Anion Transporters (OATs) and Attenuate Cytotoxicity of Adefovir Mediated by Organic Anion Transporter 1 (OAT1/SLC22A6) publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2011.01.004 – volume: 48 start-page: 383 year: 2001 ident: ref_8 article-title: Regulation of P53 Target Gene Expression by Cisplatin-Induced Extracellular Signal-Regulated Kinase publication-title: Cancer Chemother. Pharm. doi: 10.1007/s002800100318 – ident: ref_40 doi: 10.1371/journal.pone.0032673 – volume: 11 start-page: R31 year: 2007 ident: ref_18 article-title: Acute Kidney Injury Network: Report of an Initiative to Improve Outcomes in Acute Kidney Injury publication-title: Crit Care doi: 10.1186/cc5713 – volume: 303 start-page: 476 year: 2002 ident: ref_24 article-title: Protection of NRK-52E Cells, a Rat Renal Proximal Tubular Cell Line, from Chemical-Induced Apoptosis by Overexpression of a Mitochondrial Glutathione Transporter publication-title: J. Pharm. Exp. doi: 10.1124/jpet.102.040220 – volume: 53 start-page: 4318 year: 2014 ident: ref_43 article-title: Enhanced Delivery of Quercetin by Encapsulation in Poloxamers by Supercritical Antisolvent Process publication-title: Ind. Eng. Chem. Res. doi: 10.1021/ie5001136 – volume: 89 start-page: 11 year: 2014 ident: ref_39 article-title: The Flavonoid Quercetin Induces Acute Vasodilator Effects in Healthy Volunteers: Correlation with Beta-Glucuronidase Activity publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2014.07.005 – volume: 40 start-page: 1054 year: 2006 ident: ref_42 article-title: Endothelial Function and Cardiovascular Disease: Effects of Quercetin and Wine Polyphenols publication-title: Free Radic. Res. doi: 10.1080/10715760600823128 – volume: 97 start-page: 3433 year: 2017 ident: ref_45 article-title: Chemical Characterization and in Vitro Colonic Fermentation of Grape Pomace Extracts publication-title: J. Sci. Food Agric. doi: 10.1002/jsfa.8197 – ident: ref_16 doi: 10.3390/ijms22020729 – volume: 6 start-page: 35460 year: 2016 ident: ref_36 article-title: Pharmacokinetic Comparison between Quercetin and Quercetin 3-O-β-Glucuronide in Rats by UHPLC-MS/MS publication-title: Sci. Rep. doi: 10.1038/srep35460 – volume: 334 start-page: 115 year: 2007 ident: ref_1 article-title: Cisplatin Nephrotoxicity: A Review publication-title: Am. J. Med. Sci. doi: 10.1097/MAJ.0b013e31812dfe1e – volume: 145 start-page: 147 year: 2017 ident: ref_28 article-title: Distribution, Properties, and Inhibitor Sensitivity of Zebrafish Catechol-O-Methyl Transferases (COMT) publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2017.08.017 – volume: 504 start-page: 538 year: 2018 ident: ref_33 article-title: Indoxyl Glucuronide, a Protein-Bound Uremic Toxin, Inhibits Hypoxia-Inducible Factor—dependent Erythropoietin Expression through Activation of Aryl Hydrocarbon Receptor publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2018.09.018 – volume: 56 start-page: 21 year: 2016 ident: ref_10 article-title: The Biological Activities, Chemical Stability, Metabolism and Delivery Systems of Quercetin: A Review publication-title: Trends Food Sci. Technol. doi: 10.1016/j.tifs.2016.07.004 – volume: 41 start-page: 803 year: 2011 ident: ref_22 article-title: An Integrative View of the Pathophysiological Events Leading to Cisplatin Nephrotoxicity publication-title: Crit. Rev. Toxicol. doi: 10.3109/10408444.2011.602662 – ident: ref_23 doi: 10.3390/ijms18030531 – volume: 44 start-page: 16 year: 2007 ident: ref_21 article-title: Creatinine and Glomerular Filtration Rate: Evolution of an Accommodation publication-title: Ann. Clin. Biochem. doi: 10.1258/000456307779595940 – volume: 193 start-page: 232 year: 2011 ident: ref_32 article-title: Hydroxytyrosol Glucuronides Protect Renal Tubular Epithelial Cells against H2O2 Induced Oxidative Damage publication-title: Chem.-Biol. Interact. doi: 10.1016/j.cbi.2011.07.002 – volume: 24 start-page: 4760 year: 2018 ident: ref_14 article-title: Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease publication-title: Med. Sci. Monit. doi: 10.12659/MSM.909259 – volume: 5 start-page: 2393 year: 2014 ident: ref_11 article-title: The Pleiotropic Flavonoid Quercetin: From Its Metabolism to the Inhibition of Protein Kinases in Chronic Lymphocytic Leukemia publication-title: Food Funct. doi: 10.1039/C4FO00413B – volume: 107 start-page: 226 year: 2017 ident: ref_15 article-title: Differential Effect of Quercetin on Cisplatin-Induced Toxicity in Kidney and Tumor Tissues publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2017.06.047 – volume: 44 start-page: 888 year: 2016 ident: ref_34 article-title: Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.116.069575 – volume: 133 start-page: 117 year: 2001 ident: ref_41 article-title: Antihypertensive Effects of the Flavonoid Quercetin in Spontaneously Hypertensive Rats: Quercetin and Hypertension publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0704064 |
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