Structure and Formation of Z-DNA and Z-RNA

Despite structural differences between the right-handed conformations of A-RNA and B-DNA, both nucleic acids adopt very similar, left-handed Z-conformations. In contrast to their structural similarities and sequence preferences, RNA and DNA exhibit differences in their ability to adopt the Z-conform...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 28; no. 2; p. 843
Main Authors: Krall, Jeffrey B., Nichols, Parker J., Henen, Morkos A., Vicens, Quentin, Vögeli, Beat
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 14.01.2023
MDPI
Subjects:
Acids
Biology
chemical modifications
DNA - chemistry
DNA, Z-Form
hydration
junctions
Nucleic Acid Conformation
Nucleic Acids
Oxygen
Phosphates
Review
RNA
sequence preference
Z-DNA
Z-RNA
Z-RNA
sequence preference
Z-DNA
hydration
chemical modifications
junctions
ISSN:1420-3049, 1420-3049
Online Access:Get full text
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Summary:Despite structural differences between the right-handed conformations of A-RNA and B-DNA, both nucleic acids adopt very similar, left-handed Z-conformations. In contrast to their structural similarities and sequence preferences, RNA and DNA exhibit differences in their ability to adopt the Z-conformation regarding their hydration shells, the chemical modifications that promote the Z-conformation, and the structure of junctions connecting them to right-handed segments. In this review, we highlight the structural and chemical properties of both Z-DNA and Z-RNA and delve into the potential factors that contribute to both their similarities and differences. While Z-DNA has been extensively studied, there is a gap of knowledge when it comes to Z-RNA. Where such information is lacking, we try and extend the principles of Z-DNA stability and formation to Z-RNA, considering the inherent differences of the nucleic acids.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28020843