Recombinant FGF21 Protects Against Blood-Brain Barrier Leakage Through Nrf2 Upregulation in Type 2 Diabetes Mice

Blood-brain barrier (BBB) damage is a characteristic feature of diabetes mellitus pathology and plays significant roles in diabetes-associated neurological disorders. However, effective treatments for diabetes targeting BBB damage are yet to be developed. Fibroblast growth factor 21 (FGF21) is a pot...

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Bibliographic Details
Published in:	Molecular neurobiology Vol. 56; no. 4; pp. 2314 - 2327
Main Authors:	Yu, Zhanyang, Lin, Li, Jiang, Yinghua, Chin, Ian, Wang, Xiaojie, Li, Xiaokun, Lo, Eng H., Wang, Xiaoying
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.04.2019 Springer Nature B.V
Subjects:	Animals Biomedical and Life Sciences Biomedicine Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - pathology Brain injury Cell Biology Cell Membrane Permeability - drug effects Cells, Cultured Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Drug development Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Fibroblast growth factor receptor 1 Fibroblast Growth Factors - pharmacology Fibroblast Growth Factors - therapeutic use Glucose metabolism Humans Hyperglycemia Hyperglycemia - pathology Interleukin 1 Interleukin-1beta - metabolism Kelch-Like ECH-Associated Protein 1 - metabolism Lipid metabolism Male Membrane permeability Mice Microvasculature Models, Biological Neurobiology Neurological diseases Neurology Neurosciences NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Permeability Protein Binding - drug effects Proteins Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Signal Transduction - drug effects Up-regulation Up-Regulation - drug effects Hyperglycemia Nrf2 Fibroblast growth factor 21 (FGF21) Blood-brain barrier (BBB) Keap1 Inflammation Diabetes FGFR1
ISSN:	0893-7648, 1559-1182, 1559-1182
Online Access:	Get full text
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