Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata
High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from Selaginella pulvinate Carbonisat...
Saved in:
| Published in: | Molecules (Basel, Switzerland) Vol. 25; no. 3; p. 446 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
MDPI AG
21.01.2020
MDPI |
| Subjects: | |
| ISSN: | 1420-3049, 1420-3049 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from Selaginella pulvinate Carbonisata (STC) for the first time. The haemostatic effect of STC-NPs prepared at 300, 350, and 400 °C were investigated in mouse tail amputation and liver scratch experiments. STC-NPs obtained at 400 °C had the strongest haemostatic effect, and were accordingly characterised by ultraviolet–visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. STC-NPs averaged 1.4–2.8 nm and exhibited a quantum yield of 6.06% at a maximum excitation wavelength of 332 nm and emission at 432 nm. STC-NPs displayed low toxicity against mouse monocyte macrophage RAW 264.7 cells by CCK-8 assay, and STC-NP treatment significantly shortened bleeding time in rat and mouse models. Coagulation assays showed that the haemostatic effects of STC-NPs were related to improving the fibrinogen and platelet contents, as well as decreasing the prothrombin time that resulted from stimulating extrinsic blood coagulation and activating the fibrinogen system. The STC-NPs had remarkable haemostatic effects in the tail amputation and liver scratch models; these effects may be associated with the exogenous coagulation pathway and activation of the brinogen system, according to the evaluation of the mouse coagulation parameters. This novel evaluation supports the material basis of STC use in traditional Chinese medicine, and this article is worthy of study by authors of clinical pharmacy. |
|---|---|
| AbstractList | High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from Selaginella pulvinate Carbonisata (STC) for the first time. The haemostatic effect of STC-NPs prepared at 300, 350, and 400 °C were investigated in mouse tail amputation and liver scratch experiments. STC-NPs obtained at 400 °C had the strongest haemostatic effect, and were accordingly characterised by ultraviolet–visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. STC-NPs averaged 1.4–2.8 nm and exhibited a quantum yield of 6.06% at a maximum excitation wavelength of 332 nm and emission at 432 nm. STC-NPs displayed low toxicity against mouse monocyte macrophage RAW 264.7 cells by CCK-8 assay, and STC-NP treatment significantly shortened bleeding time in rat and mouse models. Coagulation assays showed that the haemostatic effects of STC-NPs were related to improving the fibrinogen and platelet contents, as well as decreasing the prothrombin time that resulted from stimulating extrinsic blood coagulation and activating the fibrinogen system. The STC-NPs had remarkable haemostatic effects in the tail amputation and liver scratch models; these effects may be associated with the exogenous coagulation pathway and activation of the brinogen system, according to the evaluation of the mouse coagulation parameters. This novel evaluation supports the material basis of STC use in traditional Chinese medicine, and this article is worthy of study by authors of clinical pharmacy. High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from (STC) for the first time. The haemostatic effect of STC-NPs prepared at 300, 350, and 400 °C were investigated in mouse tail amputation and liver scratch experiments. STC-NPs obtained at 400 °C had the strongest haemostatic effect, and were accordingly characterised by ultraviolet-visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. STC-NPs averaged 1.4-2.8 nm and exhibited a quantum yield of 6.06% at a maximum excitation wavelength of 332 nm and emission at 432 nm. STC-NPs displayed low toxicity against mouse monocyte macrophage RAW 264.7 cells by CCK-8 assay, and STC-NP treatment significantly shortened bleeding time in rat and mouse models. Coagulation assays showed that the haemostatic effects of STC-NPs were related to improving the fibrinogen and platelet contents, as well as decreasing the prothrombin time that resulted from stimulating extrinsic blood coagulation and activating the fibrinogen system. The STC-NPs had remarkable haemostatic effects in the tail amputation and liver scratch models; these effects may be associated with the exogenous coagulation pathway and activation of the brinogen system, according to the evaluation of the mouse coagulation parameters. This novel evaluation supports the material basis of STC use in traditional Chinese medicine, and this article is worthy of study by authors of clinical pharmacy. High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from Selaginella pulvinate Carbonisata (STC) for the first time. The haemostatic effect of STC-NPs prepared at 300, 350, and 400 °C were investigated in mouse tail amputation and liver scratch experiments. STC-NPs obtained at 400 °C had the strongest haemostatic effect, and were accordingly characterised by ultraviolet−visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. STC-NPs averaged 1.4−2.8 nm and exhibited a quantum yield of 6.06% at a maximum excitation wavelength of 332 nm and emission at 432 nm. STC-NPs displayed low toxicity against mouse monocyte macrophage RAW 264.7 cells by CCK-8 assay, and STC-NP treatment significantly shortened bleeding time in rat and mouse models. Coagulation assays showed that the haemostatic effects of STC-NPs were related to improving the fibrinogen and platelet contents, as well as decreasing the prothrombin time that resulted from stimulating extrinsic blood coagulation and activating the fibrinogen system. The STC-NPs had remarkable haemostatic effects in the tail amputation and liver scratch models; these effects may be associated with the exogenous coagulation pathway and activation of the brinogen system, according to the evaluation of the mouse coagulation parameters. This novel evaluation supports the material basis of STC use in traditional Chinese medicine, and this article is worthy of study by authors of clinical pharmacy. High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from Selaginella pulvinate Carbonisata (STC) for the first time. The haemostatic effect of STC-NPs prepared at 300, 350, and 400 °C were investigated in mouse tail amputation and liver scratch experiments. STC-NPs obtained at 400 °C had the strongest haemostatic effect, and were accordingly characterised by ultraviolet-visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. STC-NPs averaged 1.4-2.8 nm and exhibited a quantum yield of 6.06% at a maximum excitation wavelength of 332 nm and emission at 432 nm. STC-NPs displayed low toxicity against mouse monocyte macrophage RAW 264.7 cells by CCK-8 assay, and STC-NP treatment significantly shortened bleeding time in rat and mouse models. Coagulation assays showed that the haemostatic effects of STC-NPs were related to improving the fibrinogen and platelet contents, as well as decreasing the prothrombin time that resulted from stimulating extrinsic blood coagulation and activating the fibrinogen system. The STC-NPs had remarkable haemostatic effects in the tail amputation and liver scratch models; these effects may be associated with the exogenous coagulation pathway and activation of the brinogen system, according to the evaluation of the mouse coagulation parameters. This novel evaluation supports the material basis of STC use in traditional Chinese medicine, and this article is worthy of study by authors of clinical pharmacy.High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from Selaginella pulvinate Carbonisata (STC) for the first time. The haemostatic effect of STC-NPs prepared at 300, 350, and 400 °C were investigated in mouse tail amputation and liver scratch experiments. STC-NPs obtained at 400 °C had the strongest haemostatic effect, and were accordingly characterised by ultraviolet-visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. STC-NPs averaged 1.4-2.8 nm and exhibited a quantum yield of 6.06% at a maximum excitation wavelength of 332 nm and emission at 432 nm. STC-NPs displayed low toxicity against mouse monocyte macrophage RAW 264.7 cells by CCK-8 assay, and STC-NP treatment significantly shortened bleeding time in rat and mouse models. Coagulation assays showed that the haemostatic effects of STC-NPs were related to improving the fibrinogen and platelet contents, as well as decreasing the prothrombin time that resulted from stimulating extrinsic blood coagulation and activating the fibrinogen system. The STC-NPs had remarkable haemostatic effects in the tail amputation and liver scratch models; these effects may be associated with the exogenous coagulation pathway and activation of the brinogen system, according to the evaluation of the mouse coagulation parameters. This novel evaluation supports the material basis of STC use in traditional Chinese medicine, and this article is worthy of study by authors of clinical pharmacy. |
| Author | Kong, Hui Zhang, Yue Cheng, Jinjun Zhao, Yusheng Zhang, Meiling Luo, Juan Zhao, Yan Qu, Huihua |
| AuthorAffiliation | 2 School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China 1 School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China; 16688091339@163.com 3 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; doris7629@126.com (H.K.); 18811790361@163.com (M.Z.); carlosjjcheng@163.com (J.C.); luojuan1010@163.com (J.L.); zhaoyandr@163.com (Y.Z.) 4 Centre of Scientific Experiment, Beijing University of Chinese Medicine, Beijing 100029, China |
| AuthorAffiliation_xml | – name: 2 School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China – name: 3 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; doris7629@126.com (H.K.); 18811790361@163.com (M.Z.); carlosjjcheng@163.com (J.C.); luojuan1010@163.com (J.L.); zhaoyandr@163.com (Y.Z.) – name: 4 Centre of Scientific Experiment, Beijing University of Chinese Medicine, Beijing 100029, China – name: 1 School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China; 16688091339@163.com |
| Author_xml | – sequence: 1 givenname: Yusheng surname: Zhao fullname: Zhao, Yusheng – sequence: 2 givenname: Yue surname: Zhang fullname: Zhang, Yue – sequence: 3 givenname: Hui surname: Kong fullname: Kong, Hui – sequence: 4 givenname: Meiling surname: Zhang fullname: Zhang, Meiling – sequence: 5 givenname: Jinjun surname: Cheng fullname: Cheng, Jinjun – sequence: 6 givenname: Juan surname: Luo fullname: Luo, Juan – sequence: 7 givenname: Yan surname: Zhao fullname: Zhao, Yan – sequence: 8 givenname: Huihua surname: Qu fullname: Qu, Huihua |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31973222$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kk1v1DAQhi1URD_gB3BBkbhwCfgzsS9IdKEfUgUH4MDJmjj24lViL3ayUv89DrtFbREnj8fvPHo9M6foKMRgEXpJ8FvGFH43xsGaebCZCsww580TdEI4xXW5qKN78TE6zXmDMSWciGfomBHVMkrpCfpxBXaMeYLJm-ozhLiFVMLCrD_a5He2r859BDP5nZ9uq-gql-JYfbUDrH2wwwDVBCMkn40PUK0gdTH4DBM8R08dDNm-OJxn6PvFp2-rq_rmy-X16sNNbbhiUw2d48oaLowUXLYgKRjmXC9UQ1QDQhFKDZOubZWUjvSka4UCp5QFzgkGdoau99w-wkZvky9ubnUEr_8kYlrrw5d0J7Dp-95aTCXHAqRoKLiOUdMTIWVTWO_3rO3cjbY3NkwJhgfQhy_B_9TruNMtZk0rFsCbAyDFX7PNkx5LZ5Y2BRvnrCnjnLaCEVKkrx9JN3FOobRKU84aIRWmtKhe3Xf018rdBIug3QtMijkn67TxyzTjYtAPmmC97Ir-Z1dKJXlUeQf_f81vUfTFtg |
| CitedBy_id | crossref_primary_10_1002_cbdv_202300387 crossref_primary_10_1016_j_addr_2023_114764 crossref_primary_10_1017_erm_2023_21 crossref_primary_10_3389_fmolb_2025_1530469 crossref_primary_10_1016_j_jep_2021_114444 crossref_primary_10_3389_fmolb_2023_1223621 crossref_primary_10_1007_s11101_021_09743_7 crossref_primary_10_1002_smll_202303498 crossref_primary_10_2147_IJN_S289515 crossref_primary_10_1088_1748_605X_acdeb8 crossref_primary_10_2147_IJN_S497892 crossref_primary_10_3390_molecules26061512 |
| Cites_doi | 10.1016/j.bios.2016.02.064 10.1039/C6CP06377B 10.1186/s12951-017-0296-z 10.1039/C7NR04436D 10.1039/c2cc33844k 10.1186/1556-276X-8-122 10.1111/ijlh.12640 10.1016/S0254-6272(17)30028-6 10.1056/NEJMra0801082 10.1016/j.jcis.2017.09.007 10.2217/nnm-2018-0285 10.1016/j.saa.2017.10.054 10.1039/c3tb20859a 10.1016/j.drudis.2018.01.006 10.1002/tcr.201402090 10.1039/c2cc33796g 10.1039/C3TB21750G 10.3866/PKU.WHXB201903052 10.1039/c3nj01325a 10.3390/molecules24010128 10.1016/j.snb.2017.03.123 10.1021/acsnano.6b00043 10.1039/C8RA06340K 10.1016/j.jep.2011.03.063 10.1016/j.snb.2018.02.141 10.1016/j.jep.2019.112364 10.2217/nnm-2017-0297 10.1155/2016/4939582 10.1039/C7NR02128C 10.1016/j.jep.2011.06.018 10.1038/srep37860 10.1080/13880209.2017.1421673 10.1039/C7RA12069A 10.1016/j.msec.2013.03.018 |
| ContentType | Journal Article |
| Copyright | 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 by the authors. 2020 |
| Copyright_xml | – notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2020 by the authors. 2020 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.3390/molecules25030446 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central ProQuest One Community College ProQuest Central Korea ProQuest Health & Medical Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database Proquest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals (DOAJ) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1420-3049 |
| ExternalDocumentID | oai_doaj_org_article_b50cdddee028405a8562afb32cd15886 PMC7036756 31973222 10_3390_molecules25030446 |
| Genre | Journal Article |
| GeographicLocations | China |
| GeographicLocations_xml | – name: China |
| GroupedDBID | --- 0R~ 123 2WC 53G 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ A8Z AADQD AAFWJ AAHBH AAYXX ABDBF ABUWG ACGFO ACIWK ACPRK ACUHS AEGXH AENEX AFFHD AFKRA AFPKN AFRAH AFZYC AIAGR ALMA_UNASSIGNED_HOLDINGS BENPR BPHCQ BVXVI CCPQU CITATION CS3 D1I DIK DU5 E3Z EBD EMOBN ESTFP ESX FYUFA GROUPED_DOAJ GX1 HH5 HMCUK HYE HZ~ I09 IHR KQ8 LK8 M1P MODMG O-U O9- OK1 P2P PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO RPM SV3 TR2 TUS UKHRP ~8M ALIPV CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c493t-abf49ec45c85487a82ac3ffd596196a59122c38f77988f1d1b759af99ea4410a3 |
| IEDL.DBID | PIMPY |
| ISICitedReferencesCount | 12 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000515384800016&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1420-3049 |
| IngestDate | Fri Oct 03 12:43:25 EDT 2025 Tue Nov 04 01:59:48 EST 2025 Sun Sep 28 08:53:48 EDT 2025 Mon Oct 20 03:00:29 EDT 2025 Mon Jul 21 05:57:00 EDT 2025 Tue Nov 18 21:14:23 EST 2025 Sat Nov 29 07:10:20 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | haemostasis nanoparticles Selaginella pulvinate Carbonisata |
| Language | English |
| License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c493t-abf49ec45c85487a82ac3ffd596196a59122c38f77988f1d1b759af99ea4410a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://www.proquest.com/publiccontent/docview/2436589022?pq-origsite=%requestingapplication% |
| PMID | 31973222 |
| PQID | 2436589022 |
| PQPubID | 2032355 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_b50cdddee028405a8562afb32cd15886 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7036756 proquest_miscellaneous_2344275311 proquest_journals_2436589022 pubmed_primary_31973222 crossref_citationtrail_10_3390_molecules25030446 crossref_primary_10_3390_molecules25030446 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-01-21 |
| PublicationDateYYYYMMDD | 2020-01-21 |
| PublicationDate_xml | – month: 01 year: 2020 text: 2020-01-21 day: 21 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | Molecules (Basel, Switzerland) |
| PublicationTitleAlternate | Molecules |
| PublicationYear | 2020 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Shen (ref_21) 2017; 248 Zheng (ref_37) 2011; 137 Mewada (ref_18) 2013; 33 Feng (ref_26) 2016; 10 Zhu (ref_35) 2020; 36 Vanblerk (ref_42) 2017; 39 Sahu (ref_27) 2012; 48 Liu (ref_22) 2017; 9 Zhang (ref_8) 2018; 56 Li (ref_10) 2011; 26 Himaja (ref_32) 2015; 15 Liu (ref_12) 2018; 13 Qian (ref_4) 2010; 2 Pramanik (ref_36) 2018; 191 Ding (ref_41) 2017; 9 Chen (ref_2) 2017; 37 Xin (ref_33) 2014; 11 Li (ref_23) 2018; 263 Zhang (ref_17) 2016; 6 Chen (ref_1) 2015; 2015 Zhang (ref_5) 2018; 46 Zhao (ref_6) 2010; 35 Luo (ref_30) 2018; 8 Liu (ref_16) 2016; 2016 Mishra (ref_9) 2018; 23 Tu (ref_28) 2014; 2 Zhang (ref_11) 2018; 8 Fan (ref_40) 2011; 3 Wei (ref_13) 2014; 38 Wang (ref_24) 2013; 8 Zhu (ref_14) 2012; 48 Xin (ref_39) 2011; 135 Yang (ref_34) 2018; 509 Jahanbakhshi (ref_15) 2016; 81 Chen (ref_7) 2019; 249 Yan (ref_29) 2017; 15 ref_3 Pereira (ref_25) 2019; 30 Li (ref_20) 2017; 19 Cheng (ref_31) 2019; 14 Saha (ref_19) 2013; 1 Furie (ref_38) 2008; 359 |
| References_xml | – volume: 81 start-page: 143 year: 2016 ident: ref_15 article-title: A novel and facile synthesis of carbon quantum dots via salep hydrothermal treatment as the silver nanoparticles support: Application to electroanalytical determination of H2O2 in fetal bovine serum publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2016.02.064 – volume: 19 start-page: 11631 year: 2017 ident: ref_20 article-title: Electrochemical synthesis of phosphorus-doped graphene quantum dots for free radical scavenging publication-title: Phys. Chem. Chem. Phys. doi: 10.1039/C6CP06377B – volume: 15 start-page: 60 year: 2017 ident: ref_29 article-title: Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots publication-title: J. Nanobiotechnol. doi: 10.1186/s12951-017-0296-z – volume: 9 start-page: 14031 year: 2017 ident: ref_41 article-title: Rare earth ions enhanced near infrared fluorescence of Ag2S quantum dots for the detection of fluoride ions in living cells publication-title: Nanoscale doi: 10.1039/C7NR04436D – volume: 48 start-page: 9367 year: 2012 ident: ref_14 article-title: Bifunctional fluorescent carbon nanodots: Green synthesis via soy milk and application as metal-free electrocatalysts for oxygen reduction publication-title: Chem. Commun. doi: 10.1039/c2cc33844k – volume: 8 start-page: 122 year: 2013 ident: ref_24 article-title: Systematic safety evaluation on photoluminescent carbon dots publication-title: Nanos. Res. Lett. doi: 10.1186/1556-276X-8-122 – volume: 39 start-page: 402 year: 2017 ident: ref_42 article-title: Influence of apixaban on commonly used coagulation assays: Results from the Belgian national External Quality Assessment Scheme publication-title: Int. J. Lab. Hematol. doi: 10.1111/ijlh.12640 – volume: 37 start-page: 64 year: 2017 ident: ref_2 article-title: Effect on platelet aggregation activity: Extracts from 31 Traditional Chinese Medicines with the property of activating blood and resolving stasis publication-title: J. Tradit. Chin. Med. doi: 10.1016/S0254-6272(17)30028-6 – volume: 359 start-page: 938 year: 2008 ident: ref_38 article-title: Mechanisms of thrombus formation publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0801082 – volume: 509 start-page: 515 year: 2018 ident: ref_34 article-title: iRGD-decorated red shift emissive carbon nanodots for tumor targeting fluorescence imaging publication-title: J. Colloid Interface Sci. doi: 10.1016/j.jcis.2017.09.007 – volume: 14 start-page: 431 year: 2019 ident: ref_31 article-title: Hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots publication-title: Nanomedicine doi: 10.2217/nnm-2018-0285 – volume: 191 start-page: 498 year: 2018 ident: ref_36 article-title: Solvatochromism in highly luminescent environmental friendly carbon quantum dots for sensing applications: Conversion of bio-waste into bio-asset publication-title: Spectrochim. Acta A Mol. Biomol. Spectrosc. doi: 10.1016/j.saa.2017.10.054 – volume: 35 start-page: 2346 year: 2010 ident: ref_6 article-title: Pharmacology experimental study of new hematischesis compounds after Flos Sophorae carbonized publication-title: Zhongguo Zhong Yao Za Zhi – volume: 1 start-page: 6312 year: 2013 ident: ref_19 article-title: Fe Doped CdTeS Magnetic Quantum Dots for Bioimaging publication-title: J. Mater. Chem. B doi: 10.1039/c3tb20859a – volume: 23 start-page: 1219 year: 2018 ident: ref_9 article-title: Carbon dots: Emerging theranostic nanoarchitectures publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2018.01.006 – volume: 2015 start-page: 876426 year: 2015 ident: ref_1 article-title: Natural Products for Antithrombosis publication-title: Evid. Based Complement. Alternat. Med. – volume: 15 start-page: 595 year: 2015 ident: ref_32 article-title: Carbon Dots: The Newest Member of the Carbon Nanomaterials Family publication-title: Chem. Rec. doi: 10.1002/tcr.201402090 – volume: 48 start-page: 8835 year: 2012 ident: ref_27 article-title: Simple one-step synthesis of highly luminescent carbon dots from orange juice: Application as excellent bio-imaging agents publication-title: Chem. Commun. doi: 10.1039/c2cc33796g – volume: 2 start-page: 2184 year: 2014 ident: ref_28 article-title: PEGylated carbon nanoparticles for efficient in vitro photothermal cancer therapy publication-title: J. Mater.Chem. B doi: 10.1039/C3TB21750G – volume: 11 start-page: 1620 year: 2014 ident: ref_33 article-title: Glowing Graphene Quantum Dots and Carbon Dots: Properties, Syntheses, and Biological Applications publication-title: Small. – volume: 36 start-page: 1 year: 2020 ident: ref_35 article-title: Application of Carbon-/Graphene Quantum Dots for Supercapacitors publication-title: Acta Phys. Chim. Sin. doi: 10.3866/PKU.WHXB201903052 – volume: 46 start-page: 1562 year: 2018 ident: ref_5 article-title: Novel carbon dots derived from Schizonepetae Herba Carbonisata and investigation of their haemostatic efficacy publication-title: Artif. Cells Nanomed. Biotechnol. – volume: 3 start-page: 31 year: 2011 ident: ref_40 article-title: Study on HPLC Fingerprint Chromatogram of Selaginella tamariscina and Selaginella pulvinate and Amentoflavone Determination publication-title: Res. Pract. Chin. Med. – volume: 38 start-page: 906 year: 2014 ident: ref_13 article-title: Simple one-step synthesis of water-soluble fluorescent carbon dots from waste paper publication-title: New J. Chem. doi: 10.1039/c3nj01325a – ident: ref_3 doi: 10.3390/molecules24010128 – volume: 248 start-page: 92 year: 2017 ident: ref_21 article-title: Highly fluorescent N, S-co-doped carbon dots and their potential applications as antioxidants and sensitive probes for Cr (VI) detection publication-title: Sens. Actuators B Chem. doi: 10.1016/j.snb.2017.03.123 – volume: 10 start-page: 4410 year: 2016 ident: ref_26 article-title: Correction to Charge-Convertible Carbon Dots for Imaging-Guided Drug Delivery with Enhanced in Vivo Cancer Therapeutic Efficiency publication-title: ACS Nano doi: 10.1021/acsnano.6b00043 – volume: 8 start-page: 37707 year: 2018 ident: ref_30 article-title: Hemostatic effect of novel carbon dots derived from Cirsium setosum Carbonisata publication-title: RSC Adv. doi: 10.1039/C8RA06340K – volume: 135 start-page: 510 year: 2011 ident: ref_39 article-title: Dragon’s Blood extract has antithrombotic properties, affecting platelet aggregation functions and anticoagulation activities publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2011.03.063 – volume: 263 start-page: 426 year: 2018 ident: ref_23 article-title: Green synthesis of fluorescent carbon dots from Hongcaitai for selective detection of hypochlorite and mercuric ions and cell imaging publication-title: Sens. Actuators B Chem. doi: 10.1016/j.snb.2018.02.141 – volume: 249 start-page: 112364 year: 2019 ident: ref_7 article-title: Hemostatic action of lotus leaf charcoal is probably due to transformation of flavonol aglycons from flavonol glucosides in traditional Chinses medicine publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2019.112364 – volume: 13 start-page: 391 year: 2018 ident: ref_12 article-title: Novel Phellodendri Cortex (Huang Bo)-derived carbon dots and their hemostatic effect publication-title: Nanomedicine doi: 10.2217/nnm-2017-0297 – volume: 2016 start-page: 4939582 year: 2016 ident: ref_16 article-title: A Novel Ratiometric Probe Based on Nitrogen-Doped Carbon Dots and Rhodamine B Isothiocyanate for Detection of Fe(3+) in Aqueous Solution publication-title: J. Anal. Methods Chem. doi: 10.1155/2016/4939582 – volume: 30 start-page: 2536 year: 2019 ident: ref_25 article-title: (Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dots publication-title: J. Braz. Chem. Soc. – volume: 9 start-page: 7135 year: 2017 ident: ref_22 article-title: One-step hydrothermal synthesis of photoluminescent carbon nanodots with selective antibacterial activity against Porphyromonas gingivalis publication-title: Nanoscale doi: 10.1039/C7NR02128C – volume: 137 start-page: 662 year: 2011 ident: ref_37 article-title: Anti-diabetic activity and potential mechanism of total flavonoids of Selaginella tamariscina (Beauv.) Spring in rats induced by high fat diet and low dose STZ publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2011.06.018 – volume: 2 start-page: 157 year: 2010 ident: ref_4 article-title: Pharmacopoeia of the People’s Republic of China (2010 Edition): A Milestone in Development of China’s Healthcare publication-title: China Med. Sci. Technol. Press – volume: 6 start-page: 37860 year: 2016 ident: ref_17 article-title: In vivo characterization of hair and skin derived carbon quantum dots with high quantum yield as long-term bioprobes in zebrafish publication-title: Sci. Rep. doi: 10.1038/srep37860 – volume: 56 start-page: 67 year: 2018 ident: ref_8 article-title: Comparing coagulation activity of Selaginella tamariscina before and after stir-frying process and determining the possible active constituents based on compositional variation publication-title: Pharm. Biol. doi: 10.1080/13880209.2017.1421673 – volume: 8 start-page: 1168 year: 2018 ident: ref_11 article-title: Berberine-based carbon dots for selective and safe cancer theranostics publication-title: RSC Adv. doi: 10.1039/C7RA12069A – volume: 26 start-page: 194 year: 2011 ident: ref_10 article-title: Comparison of Contents of Total Flavonoids in Different Processed Products of Selaginella publication-title: China J. Chin. Med. – volume: 33 start-page: 2914 year: 2013 ident: ref_18 article-title: Green synthesis of biocompatible carbon dots using aqueous extract of Trapa bispinosa peel publication-title: Mater. Sci. Eng. C doi: 10.1016/j.msec.2013.03.018 |
| SSID | ssj0021415 |
| Score | 2.3823018 |
| Snippet | High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 446 |
| SubjectTerms | Animals Biocompatible Materials - pharmacology Blood Coagulation - drug effects Carbon Cell Death - drug effects Cell Survival - drug effects Charcoal Chromatography, High Pressure Liquid Drug dosages haemostasis Hemostatics - pharmacology Liver Medical research Mice Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Photoelectron Spectroscopy Rats RAW 264.7 Cells selaginella pulvinate carbonisata Selaginellaceae - chemistry Spectrum analysis Temperature Traditional Chinese medicine |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals (DOAJ) dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEA9yCPoifls9pYJPQrjma5M8eqvHPcgh-MH5VCZpgoXb9tjt3d_vTNtdblX0xdcmhXRm0pkfk_x-jL0RIWYXbORYfWaupbbcQ6g4AHgTk5Rx5Nn-9tGenbnzc__phtQXnQmb6IEnwx0FU8UG92DCRIjFBThM2JCDkrERxrmRbBurni2YmqGWwLw09TAVgvqj1SQ1mzaY8BW1MPey0EjW_6cK89eDkjcyz8l9dm8uGct301IfsFupe8juLLdKbY_Y91NIq56uBrWxxN8l4uD5uBt_jwF2nZryuO3pBgMJRZR9LulSSfk5XZBEER1_KgdYkRphbDsol7AOPTW5B3jMvp58-LI85bNkAo_aq4FDyNqnqE10BEXASYgq58Z4BEoLMF6g9ZXLlmjKsmhEsMZD9j4B1kUVqCfsoOu79IyVvjFaVwmy00EbB26hdLIJXaGt1g0UrNqasI4znzjJWlzUiCvI6vVvVi_Y290rlxOZxt8mH5NfdhOJB3t8gNFRz2as_xUdBTvcerWeN-emllph3eWxeinY690w-ox6JdCl_grnKK0lQjkhCvZ0CoLdSvCvZalBVTC7Fx57S90f6dofI3U30Z1Zs3j-P77tBbsrCfxXgktxyA6G9VV6yW7H66HdrF-N--EnpJMVEw priority: 102 providerName: Directory of Open Access Journals |
| Title | Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31973222 https://www.proquest.com/docview/2436589022 https://www.proquest.com/docview/2344275311 https://pubmed.ncbi.nlm.nih.gov/PMC7036756 https://doaj.org/article/b50cdddee028405a8562afb32cd15886 |
| Volume | 25 |
| WOSCitedRecordID | wos000515384800016&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: DOA dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Health Medical collection customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: 7X7 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: BENPR dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: PIMPY dateStart: 19970101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwEB6xLRJceC8UlipInJCi5uHU9gnRsqtFgqripe4pmjg2RNomS5vd389MkgYKaE9cekjcyunnzMMz_j6Al2FmnMqk8Sn6dL6IhPQ1ZoGPiDoxNopMw7P99b1cLNRqpZfd8eht11a5s4mNoW7Znrlvm4zwJK8M75hPIhGT69TkgF5f_PBZQ4prrZ2gxgEMmXhLDWC4fPdhedYnYCF5q7ayGVOqP1m3ArR2S2FAzIXNPd_UUPj_K-78s33yN390cvf_Psk9uNPFpd6bdiHdhxu2fAC35js5uIdwdop2XfH5o8J4ZJMp2e566vy3tIqvbO7NioqPSbAahVc5j0-ueJ_sOesgcY-VV-OaJQ9NUaI3x01WcSW9xkfw5eT48_zU73QZfCN0XPuYOaGtEYlRnO-gitDEzuWJpmxsiokOCeJYOclcaC7Mw0wmGp3WFin4CjA-hEFZlfYJeDonoAKLTolMJArVNBZWWrK5QgqR4wiCHSKp6UjLWTvjPKXkhUFM_wJxBK_6r1y0jB3XDZ4xzP1AJttuLlSbb2n3N6ZZEpicpmQpFqP4FhXFjOiyODJ5mChFP3K0AzrtLMA2_YXrCF70twkzLshgaatLGhMLEVG-GIYjeNyuqX4mZBolV8FGIPdW295U9--UxfeGH5w51WQyfXr9tJ7B7Yj3DoLQj8IjGNSbS_scbpqruthuxnAgV7L5VGMYzo4Xy4_jZr9i3L1UPwF-hjQS |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELZKQSoX3o9AgSDBBSlqYjtr-4AQ3VJt1WWFREHLKUwcG1bqJsvutog_xW9kJo8tC6i3HrgmTjSJP8_DM56PsWdJbr3OlY3Q-_SR5FJFBvI4AgCTWse5rftsfxyq0UiPx-bdBvvZnYWhsspOJ9aKuqgs7ZHvcCnQWBo0Oa9m3yJijaLsakeh0cDi0P34jiHb4uXBHs7vc8733xz1B1HLKhBZacQygtxL46xMrSZvHTQHK7wvUoOxRA9Sk6CAQntFnbx8UiS5Sg14Yxyg6xCDwPdeYpdRjysqIVPjswAvQWvYZE6FMPHOtCG4dQt0MwQlTtdsX00R8C-_9s_yzN_s3f71_-1P3WDXWs86fN0shZtsw5W32Fa_I7S7zT4NwE0rOkE1sSFalWrWVQVGe7gOT10R7k4qOuhBfBph5UM6exO-d8fE5ERVYuESpkTaaCclhH2Y5xXVAizhDvtwIV92l22WVenus9AUqZSxA69lLlMNuiekUw6thlRSFhCwuJvzzLZt14n94zjD8Itgkv0Fk4C9WD0ya3qOnDd4l4C0GkjtwusL1fxL1v7GLE9jW6BIDr1J9NBBo9cLPhfcFkmqNb5ku4NS1uqwRXaGo4A9Xd3GOaOUEpSuOsExQkqOEW-SBOxeg9qVJKjcFeXxAqbW8Lwm6vqdcvK17nBOXeFU2ntwvlhP2Nbg6O0wGx6MDh-yq5x2QuIk4sk221zOT9wjdsWeLieL-eN6mYbs80Wj_RdQCX8- |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VgoALb0qggJHggmTF3l1ndw8I0YSoVauoEg-Fkzte79JIjR2StIi_xq9jxo-UAOqtB67x2pp4v935xjM7H2Mv48x6nSkbIvv0oeRShQayKAQAk1jHua36bH8-UKORHo_N4Qb72Z6FobLKdk-sNuq8tPSNvMulQGdp0OV0fVMWcTgYvp19C0lBijKtrZxGDZF99-M7hm-LN3sDnOtXnA_ff-zvho3CQGilEcsQMi-NszKxmpg7aA5WeJ8nBuOKHiQmRmOF9oq6evk4jzOVGPDGOEAaEYHA515hV5UQimQj1Pg82IvRM9ZZVCFM1J3WYrdugZRDUBJ1zQ9WcgH_4rh_lmr-5vuGt__nt3aH3WoYd_CuXiJ32YYr7rEb_Vbo7j77sgtuWtLJqokN0NuUs7ZaMBzg-jxzebAzKekACOlsBKUP6ExO8MGdkMITVY8FS5iSmKOdFBD0YZ6VVCOwhAfs06X8s4dssygL94gFJk-kjBx4LTOZaNA9IZ1y6E2kkjKHDova-U9t046dVEFOUgzLCDLpX5DpsNerW2Z1L5KLBu8QqFYDqY149UM5_5o2rzHNksjmaJJDlonMHTSyYfCZ4DaPE63xIdstrNJmb1uk55jqsBeryzhnlGqCwpWnOEZIyTESjuMO26oRvLIEN31F-b0OU2vYXjN1_UoxOa46n1O3OJX0Hl9s1nN2HUGeHuyN9p-wm5w-kERxyONttrmcn7qn7Jo9W04W82fVig3Y0WWD_Rc56Ify |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Haemostatic+Nanoparticles-Derived+Bioactivity+of+from+Selaginella+tamariscina+Carbonisata&rft.jtitle=Molecules+%28Basel%2C+Switzerland%29&rft.au=Zhao%2C+Yusheng&rft.au=Zhang%2C+Yue&rft.au=Kong%2C+Hui&rft.au=Zhang%2C+Meiling&rft.date=2020-01-21&rft.pub=MDPI+AG&rft.eissn=1420-3049&rft.volume=25&rft.issue=3&rft.spage=446&rft_id=info:doi/10.3390%2Fmolecules25030446&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1420-3049&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1420-3049&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1420-3049&client=summon |