Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score regression (LDSC) and genomic restricted maximum likelihood (GREML). The massively...

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Veröffentlicht in:	American journal of human genetics Jg. 102; H. 6; S. 1185
Hauptverfasser:	Ni, Guiyan, Moser, Gerhard, Wray, Naomi R, Lee, S Hong
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 07.06.2018
Schlagworte:	Adult Body Height - genetics Computer Simulation Databases, Genetic Genome, Human Genotype Haplotypes - genetics Humans Inheritance Patterns - genetics Likelihood Functions Linkage Disequilibrium - genetics Phenotype Polymorphism, Single Nucleotide - genetics Regression Analysis Schizophrenia - genetics biasedness genome-wide SNPs body mass index linkage disequilibrium score regression accuracy genetic correlation schizophrenia genomic restricted maximum likelihood SNP heritability height
ISSN:	1537-6605, 1537-6605
Online-Zugang:	Weitere Angaben
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