Green Synthesis of Silver Nanoparticles Using Salvia verticillata and Filipendula ulmaria Extracts: Optimization of Synthesis, Biological Activities, and Catalytic Properties

The study’s objective was to obtain silver nanoparticles (SVAgNP and FUAgNP) using aqueous extracts of Salvia verticillata and Filipendula ulmaria. The optimal conditions for nanoparticle synthesis were determined and obtained; nanoparticles were then characterized using UV-Vis, Fourier-transform in...

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Vydáno v:Molecules (Basel, Switzerland) Ročník 28; číslo 2; s. 808
Hlavní autoři: Mihailović, Vladimir, Srećković, Nikola, Nedić, Zoran P., Dimitrijević, Silvana, Matić, Miloš, Obradović, Ana, Selaković, Dragica, Rosić, Gvozden, Katanić Stanković, Jelena S.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 13.01.2023
MDPI
Témata:
Acids
Anti-Bacterial Agents - chemistry
antimicrobial activity
Antimicrobial agents
antioxidant activity
Antioxidants
cell viability
Colorectal cancer
Filipendula
Flavonoids
Humans
meadowsweet
Metal Nanoparticles - chemistry
Nanoparticles
Nanotechnology
Phytochemicals
Plant Extracts - chemistry
Plant Extracts - pharmacology
Salvia
Silver
Silver - chemistry
silver nanoparticles
Spectroscopy, Fourier Transform Infrared
meadowsweet
cell viability
antimicrobial activity
silver nanoparticles
Salvia
antioxidant activity
ISSN:1420-3049, 1420-3049
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Shrnutí:The study’s objective was to obtain silver nanoparticles (SVAgNP and FUAgNP) using aqueous extracts of Salvia verticillata and Filipendula ulmaria. The optimal conditions for nanoparticle synthesis were determined and obtained; nanoparticles were then characterized using UV-Vis, Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), Dynamic Light Scattering (DLS), Scanning Electron Microscopy with Energy Dispersive Spectroscopy (SEM/EDS). SVAgNP and FUAgNP possessed a crystalline structure with 48.42% and 60.41% silver weight, respectively. The highest percentage of nanoparticles in the solution had a diameter between 40 and 70 nm. In DPPH˙ and ABTS˙+ methods, FUAgNP (IC50 15.82 and 59.85 µg/mL, respectively) demonstrated a higher antioxidant capacity than SVAgNP (IC50 73.47 and 79.49 µg/mL, respectively). Obtained nanoparticles also showed pronounced antibacterial activity (MIC ˂ 39.1 µg/mL for most of the tested bacteria), as well as high biocompatibility with the human fibroblast cell line MRC-5 and significant cytotoxicity on some cancer cell lines, especially on the human colon cancer HCT-116 cells (IC50 31.50 and 66.51 µg/mL for SVAgNP and FUAgNP, respectively). The nanoparticles demonstrated high catalytic effectiveness in degrading Congo red dye with NaBH4. The results showed a rapid and low-cost methodology for the synthesis of AgNPs using S. verticillata and F. ulmaria with promising biological potential.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28020808