Chemical Composition, Antimicrobial, Antioxidant, and Antiproliferative Properties of Grapefruit Essential Oil Prepared by Molecular Distillation

Grapefruit essential oil has been proven to have wide range of bioactivities. However, bioactivity of its molecular distillate has not been well studied. In this study, a light phase oil was obtained by molecular distillation from cold-pressed grapefruit essential oil and GC-MS was used to identify...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 25; no. 1; p. 217
Main Authors: Deng, Weihui, Liu, Ke, Cao, Shan, Sun, Jingyu, Zhong, Balian, Chun, Jiong
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 05.01.2020
MDPI
Subjects:
anticancer activity
antimicrobial
Antimicrobial agents
antioxidant
Antioxidants
Bacteria
Biological activity
By products
Cancer
Citrus fruits
Cold
Colorectal cancer
E coli
Essential oils
Food preservation
gc-ms
grapefruit essential oil
Microorganisms
molecular distillation
Oils & fats
Phytochemicals
GC-MS
antimicrobial
grapefruit essential oil
antioxidant
anticancer activity
molecular distillation
ISSN:1420-3049, 1420-3049
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Grapefruit essential oil has been proven to have wide range of bioactivities. However, bioactivity of its molecular distillate has not been well studied. In this study, a light phase oil was obtained by molecular distillation from cold-pressed grapefruit essential oil and GC-MS was used to identify its chemical composition. The antimicrobial activity of the light phase oil was tested by filter paper diffusion method, and the anticancer activity was determined by the Cell Counting Kit-8 (CCK-8) assay. Twenty-four components were detected with a total relative content of 99.74%, including 97.48% of terpenes and 1.66% of oxygenated terpenes. The light phase oil had the best antimicrobial effect on Bacillus subtilis, followed by Escherichia coli, Staphylococcus aureus and Salmonellaty phimurium. DPPH and ABTS assays demonstrated that the light phase oil had good antioxidant activity. The CCK-8 assay of cell proliferation showed that the light phase oil had a good inhibitory effect on the proliferation of HepG2 liver cancer cells and HCT116 colon cancer cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25010217