Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation

Astrocytes are instrumental in maintaining central nervous system (CNS) homeostasis and responding to injury. A major limitation of studying neurodegenerative diseases like multiple sclerosis (MS) is lack of human pathological specimens obtained during the acute stages, thereby relegating research t...

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Veröffentlicht in:	Frontiers in molecular neuroscience Jg. 15; S. 874299
Hauptverfasser:	Smith, Matthew D., Chamling, Xitiz, Gill, Alexander J., Martinez, Hector, Li, Weifeng, Fitzgerald, Kathryn C., Sotirchos, Elias S., Moroziewicz, Dorota, Bauer, Lauren, Paull, Daniel, Gharagozloo, Marjan, Bhargava, Pavan, Zack, Donald J., Fossati, Valentina, Calabresi, Peter A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Research Foundation 06.05.2022 Frontiers Media S.A
Schlagworte:	Alzheimer's disease astrocyte Astrocytes Cell differentiation Cytokines Cytotoxicity Gene expression Genotype & phenotype Glial stem cells Homeostasis induced pluripotent stem cell (iPSC) Inflammation Interleukin 1 Leukocytes Molecular Neuroscience Multiple sclerosis Myelin Myelination Nervous system Neurodegeneration Neurodegenerative diseases Neurotoxicity oligodendrocyte Oligodendrocytes Ontology Pluripotency Principal components analysis Stem cell transplantation Stem cells Transcription Transcriptomes Tumor necrosis factor induced pluripotent stem cell (iPSC) neurotoxicity astrocyte multiple sclerosis oligodendrocyte
ISSN:	1662-5099, 1662-5099
Online-Zugang:	Volltext
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