Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase

Chronic stress is the key factor contributing to the development of depressive symptoms. Chronic restraint stress (CRS) is well validated and is one of the most commonly used models to induce depressive-like behavior in rodents. The present study aimed to evaluate whether fluoxetine (FLU 5 mg/kg) an...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 27; no. 1; p. 22
Main Authors:	Misztak, Paulina, Sowa-Kućma, Magdalena, Pańczyszyn-Trzewik, Patrycja, Szewczyk, Bernadeta, Nowak, Gabriel
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 21.12.2021 MDPI
Subjects:	an animal model of depression Animals Antidepressants Antidepressive Agents - pharmacology Anxiety Behavior Behavior, Animal - drug effects Brain chronic restraint stress Cytokines Depression - drug therapy Disease Models, Animal Dose-Response Relationship, Drug Epigenetics fluoxetine Fluoxetine - pharmacology Hindlimb Suspension Histone Deacetylases - metabolism Humans Male Mental depression Mental disorders Mice Mice, Inbred C57BL Oxidative stress Pyroptosis Stress, Psychological - metabolism zinc Zinc - pharmacology antidepressants chronic restraint stress fluoxetine an animal model of depression zinc
ISSN:	1420-3049, 1420-3049
Online Access:	Get full text
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