β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response of muscle to exercise. Muscle PGC-1α transgenic expression and exercise both increase the expression of thermogenic ge...

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Veröffentlicht in:	Cell metabolism Jg. 19; H. 1; S. 96
Hauptverfasser:	Roberts, Lee D, Boström, Pontus, O'Sullivan, John F, Schinzel, Robert T, Lewis, Gregory D, Dejam, Andre, Lee, Youn-Kyoung, Palma, Melinda J, Calhoun, Sondra, Georgiadi, Anastasia, Chen, Ming-Huei, Ramachandran, Vasan S, Larson, Martin G, Bouchard, Claude, Rankinen, Tuomo, Souza, Amanda L, Clish, Clary B, Wang, Thomas J, Estall, Jennifer L, Soukas, Alexander A, Cowan, Chad A, Spiegelman, Bruce M, Gerszten, Robert E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 07.01.2014
Schlagworte:	Adipocytes, Brown - drug effects Adipocytes, Brown - metabolism Adipocytes, Brown - pathology Adipocytes, White - drug effects Adipocytes, White - metabolism Adipocytes, White - pathology Adipose Tissue, Brown - cytology Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Adipose Tissue, White - cytology Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism Aminoisobutyric Acids - blood Aminoisobutyric Acids - pharmacology Animals Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cell Differentiation - drug effects Exercise Gene Expression Regulation - drug effects Glucose Tolerance Test Humans Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Liver - drug effects Liver - metabolism Metabolic Diseases - metabolism Metabolic Diseases - pathology Mice Organ Specificity - drug effects Organ Specificity - genetics Oxidation-Reduction - drug effects Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Phenotype Physical Conditioning, Animal PPAR alpha - metabolism Risk Factors Transcription Factors - metabolism Transcription, Genetic - drug effects Weight Gain - drug effects
ISSN:	1932-7420, 1932-7420
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