Inverse association between serum free thyroxine levels and hepatic steatosis: results from the Study of Health in Pomerania

Associations between thyroid function and hepatic steatosis defined by enzymatic and sonographic criteria are largely unknown in the general population. Thus, the aim of the present study was to investigate the association between thyroid function tests and sonographic as well as enzymatic criteria...

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Vydáno v:Thyroid (New York, N.Y.) Ročník 22; číslo 6; s. 568
Hlavní autoři: Ittermann, Till, Haring, Robin, Wallaschofski, Henri, Baumeister, Sebastian E, Nauck, Matthias, Dörr, Marcus, Lerch, Markus M, Lerch, Markus, Meyer zu Schwabedissen, Henriette E, Rosskopf, Dieter, Völzke, Henry
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.06.2012
Témata:
Adult
Aged
Alanine Transaminase - blood
Cross-Sectional Studies
Fatty Liver - blood
Fatty Liver - epidemiology
Fatty Liver - ethnology
Female
Germany - epidemiology
Humans
Liver - diagnostic imaging
Male
Middle Aged
Prevalence
Risk Factors
Self Report
Thyroxine - blood
Ultrasonography
ISSN:1557-9077, 1557-9077
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Popis
Shrnutí:Associations between thyroid function and hepatic steatosis defined by enzymatic and sonographic criteria are largely unknown in the general population. Thus, the aim of the present study was to investigate the association between thyroid function tests and sonographic as well as enzymatic criteria of liver status in a large population-based study, the Study of Health in Germany (SHIP). Data from 3661 SHIP participants without a self-reported history of thyroid or liver disease were analyzed. Hepatic steatosis was defined as the presence of a hyperechogenic ultrasound pattern of the liver and increased serum alanine transferase concentrations. Serum thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) concentrations were associated with hepatic steatosis using multinomial regression models adjusted for sex, age, physical activity, alcohol consumption, waist circumference, and food intake pattern. We detected no consistent association of serum TSH and FT3 concentrations with hepatic steatosis. In contrast, serum FT4 concentrations were inversely associated with hepatic steatosis in men (odds ratio (OR)=0.04 [95% confidence interval (CI)=0.01; 0.17]) and women (OR=0.06 [95% CI=0.01; 0.42]). Results from the present cross-sectional study suggest that low FT4 concentrations are associated with hepatic steatosis. Longitudinal and intervention studies are warranted to investigate whether hypothyroidism increases the risk of hepatic steatosis or vice versa.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1557-9077
1557-9077
DOI:10.1089/thy.2011.0279