Novel Carbon Dots Derived from Puerariae lobatae Radix and Their Anti-Gout Effects

Gout is a disease with a high incidence and causing great harm, and the current treatment drugs are not satisfactory. In this study, novel water-soluble carbon dots (CDs) with anti-gout effect, named Puerariae lobatae Radix CDs (PLR-CDs), are reported. PLR-CDs were synthesized with an improved pyrol...

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Published in:	Molecules (Basel, Switzerland) Vol. 24; no. 22; p. 4152
Main Authors:	Wang, Xiaoke, Zhang, Yue, Zhang, Meiling, Kong, Hui, Wang, Suna, Cheng, Jinjun, Qu, Huihua, Zhao, Yan
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 16.11.2019 MDPI
Subjects:	Animals Biocompatibility Biological activity Biopsy Carbon Carbon - chemistry carbon dots Cell Survival - drug effects Cytotoxicity Disease Models, Animal Drugs Gout - drug therapy Gout - etiology Gout - pathology Gout Suppressants - chemistry Gout Suppressants - pharmacology gouty hyperuricemia Mice Nanomaterials Nanoparticles - chemistry Nanoparticles - ultrastructure new agents Optical properties pueraria Pueraria - chemistry Quantum Dots - chemistry Quantum Dots - ultrastructure Rats RAW 264.7 Cells Rheumatism Spectrum Analysis Uric acid carbon dots hyperuricemia new agents gouty uric acid Pueraria
ISSN:	1420-3049, 1420-3049
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Abstract	Gout is a disease with a high incidence and causing great harm, and the current treatment drugs are not satisfactory. In this study, novel water-soluble carbon dots (CDs) with anti-gout effect, named Puerariae lobatae Radix CDs (PLR-CDs), are reported. PLR-CDs were synthesized with an improved pyrolysis method at 300 °C, and their characterization was performed with multifaceted approaches, such as transmission electron microscopy (TEM) and ultraviolet–visible (UV–vis) and Fourier-transform infrared (FTIR) spectroscopy. In addition, the biocompatibility of PLR-CDs was studied using the cell counting kit (CCK)-8 in LO2 cells and RAW264.7 cells, and the anti-gout activity of PLR-CDs was examined on animal models of hyperuricemia and gouty arthritis. The characterization of PLR-CDs indicated that they were nearly spherical, with diameters ranging from 3.0 to 10.0 nm, and the lattice spacing was 0.283 nm. The toxicity experiment revealed that PLR-CDs were non-poisonous for LO2 cells and RAW264.7 cells at concentrations below 250 μg/mL. The results of pharmacodynamic experiments showed that PLR-CDs could lower the blood uric acid level in model rats by inhibiting the activity of xanthine oxidase and reduce the degree of swelling and pathological damage of gouty arthritis. Thus, PLR-CDs with anti-gout biological activity and good biocompatibility have the prospect of clinical application for the treatment of gout.
AbstractList	Gout is a disease with a high incidence and causing great harm, and the current treatment drugs are not satisfactory. In this study, novel water-soluble carbon dots (CDs) with anti-gout effect, named Puerariae lobatae Radix CDs (PLR-CDs), are reported. PLR-CDs were synthesized with an improved pyrolysis method at 300 °C, and their characterization was performed with multifaceted approaches, such as transmission electron microscopy (TEM) and ultraviolet-visible (UV-vis) and Fourier-transform infrared (FTIR) spectroscopy. In addition, the biocompatibility of PLR-CDs was studied using the cell counting kit (CCK)-8 in LO2 cells and RAW264.7 cells, and the anti-gout activity of PLR-CDs was examined on animal models of hyperuricemia and gouty arthritis. The characterization of PLR-CDs indicated that they were nearly spherical, with diameters ranging from 3.0 to 10.0 nm, and the lattice spacing was 0.283 nm. The toxicity experiment revealed that PLR-CDs were non-poisonous for LO2 cells and RAW264.7 cells at concentrations below 250 μg/mL. The results of pharmacodynamic experiments showed that PLR-CDs could lower the blood uric acid level in model rats by inhibiting the activity of xanthine oxidase and reduce the degree of swelling and pathological damage of gouty arthritis. Thus, PLR-CDs with anti-gout biological activity and good biocompatibility have the prospect of clinical application for the treatment of gout.Gout is a disease with a high incidence and causing great harm, and the current treatment drugs are not satisfactory. In this study, novel water-soluble carbon dots (CDs) with anti-gout effect, named Puerariae lobatae Radix CDs (PLR-CDs), are reported. PLR-CDs were synthesized with an improved pyrolysis method at 300 °C, and their characterization was performed with multifaceted approaches, such as transmission electron microscopy (TEM) and ultraviolet-visible (UV-vis) and Fourier-transform infrared (FTIR) spectroscopy. In addition, the biocompatibility of PLR-CDs was studied using the cell counting kit (CCK)-8 in LO2 cells and RAW264.7 cells, and the anti-gout activity of PLR-CDs was examined on animal models of hyperuricemia and gouty arthritis. The characterization of PLR-CDs indicated that they were nearly spherical, with diameters ranging from 3.0 to 10.0 nm, and the lattice spacing was 0.283 nm. The toxicity experiment revealed that PLR-CDs were non-poisonous for LO2 cells and RAW264.7 cells at concentrations below 250 μg/mL. The results of pharmacodynamic experiments showed that PLR-CDs could lower the blood uric acid level in model rats by inhibiting the activity of xanthine oxidase and reduce the degree of swelling and pathological damage of gouty arthritis. Thus, PLR-CDs with anti-gout biological activity and good biocompatibility have the prospect of clinical application for the treatment of gout. Gout is a disease with a high incidence and causing great harm, and the current treatment drugs are not satisfactory. In this study, novel water-soluble carbon dots (CDs) with anti-gout effect, named Radix CDs (PLR-CDs), are reported. PLR-CDs were synthesized with an improved pyrolysis method at 300 °C, and their characterization was performed with multifaceted approaches, such as transmission electron microscopy (TEM) and ultraviolet-visible (UV-vis) and Fourier-transform infrared (FTIR) spectroscopy. In addition, the biocompatibility of PLR-CDs was studied using the cell counting kit (CCK)-8 in LO2 cells and RAW264.7 cells, and the anti-gout activity of PLR-CDs was examined on animal models of hyperuricemia and gouty arthritis. The characterization of PLR-CDs indicated that they were nearly spherical, with diameters ranging from 3.0 to 10.0 nm, and the lattice spacing was 0.283 nm. The toxicity experiment revealed that PLR-CDs were non-poisonous for LO2 cells and RAW264.7 cells at concentrations below 250 μg/mL. The results of pharmacodynamic experiments showed that PLR-CDs could lower the blood uric acid level in model rats by inhibiting the activity of xanthine oxidase and reduce the degree of swelling and pathological damage of gouty arthritis. Thus, PLR-CDs with anti-gout biological activity and good biocompatibility have the prospect of clinical application for the treatment of gout. Gout is a disease with a high incidence and causing great harm, and the current treatment drugs are not satisfactory. In this study, novel water-soluble carbon dots (CDs) with anti-gout effect, named Puerariae lobatae Radix CDs (PLR-CDs), are reported. PLR-CDs were synthesized with an improved pyrolysis method at 300 °C, and their characterization was performed with multifaceted approaches, such as transmission electron microscopy (TEM) and ultraviolet−visible (UV−vis) and Fourier-transform infrared (FTIR) spectroscopy. In addition, the biocompatibility of PLR-CDs was studied using the cell counting kit (CCK)-8 in LO2 cells and RAW264.7 cells, and the anti-gout activity of PLR-CDs was examined on animal models of hyperuricemia and gouty arthritis. The characterization of PLR-CDs indicated that they were nearly spherical, with diameters ranging from 3.0 to 10.0 nm, and the lattice spacing was 0.283 nm. The toxicity experiment revealed that PLR-CDs were non-poisonous for LO2 cells and RAW264.7 cells at concentrations below 250 μg/mL. The results of pharmacodynamic experiments showed that PLR-CDs could lower the blood uric acid level in model rats by inhibiting the activity of xanthine oxidase and reduce the degree of swelling and pathological damage of gouty arthritis. Thus, PLR-CDs with anti-gout biological activity and good biocompatibility have the prospect of clinical application for the treatment of gout. Gout is a disease with a high incidence and causing great harm, and the current treatment drugs are not satisfactory. In this study, novel water-soluble carbon dots (CDs) with anti-gout effect, named Puerariae lobatae Radix CDs (PLR-CDs), are reported. PLR-CDs were synthesized with an improved pyrolysis method at 300 °C, and their characterization was performed with multifaceted approaches, such as transmission electron microscopy (TEM) and ultraviolet–visible (UV–vis) and Fourier-transform infrared (FTIR) spectroscopy. In addition, the biocompatibility of PLR-CDs was studied using the cell counting kit (CCK)-8 in LO2 cells and RAW264.7 cells, and the anti-gout activity of PLR-CDs was examined on animal models of hyperuricemia and gouty arthritis. The characterization of PLR-CDs indicated that they were nearly spherical, with diameters ranging from 3.0 to 10.0 nm, and the lattice spacing was 0.283 nm. The toxicity experiment revealed that PLR-CDs were non-poisonous for LO2 cells and RAW264.7 cells at concentrations below 250 μg/mL. The results of pharmacodynamic experiments showed that PLR-CDs could lower the blood uric acid level in model rats by inhibiting the activity of xanthine oxidase and reduce the degree of swelling and pathological damage of gouty arthritis. Thus, PLR-CDs with anti-gout biological activity and good biocompatibility have the prospect of clinical application for the treatment of gout.
Author	Kong, Hui Zhang, Yue Cheng, Jinjun Zhang, Meiling Wang, Xiaoke Wang, Suna Qu, Huihua Zhao, Yan
AuthorAffiliation	2 School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100102, China; 201801024@bucm.edu.cn 3 Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing 100102, China; quhuihuadr@163.com 1 School of Preclinical Medicine, Beijing Key Laboratory, Beijing University of Chinese Medicine, Beijing 100102, China; wangxiaoke@bucm.edu.cn (X.W.); 18811790361@163.com (M.Z.); doris7629@126.com (H.K.); wsn8212@163.com (S.W.); carlosjjcheng@163.com (J.C.)
AuthorAffiliation_xml	– name: 1 School of Preclinical Medicine, Beijing Key Laboratory, Beijing University of Chinese Medicine, Beijing 100102, China; wangxiaoke@bucm.edu.cn (X.W.); 18811790361@163.com (M.Z.); doris7629@126.com (H.K.); wsn8212@163.com (S.W.); carlosjjcheng@163.com (J.C.) – name: 2 School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100102, China; 201801024@bucm.edu.cn – name: 3 Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing 100102, China; quhuihuadr@163.com
Author_xml	– sequence: 1 givenname: Xiaoke surname: Wang fullname: Wang, Xiaoke – sequence: 2 givenname: Yue surname: Zhang fullname: Zhang, Yue – sequence: 3 givenname: Meiling surname: Zhang fullname: Zhang, Meiling – sequence: 4 givenname: Hui surname: Kong fullname: Kong, Hui – sequence: 5 givenname: Suna surname: Wang fullname: Wang, Suna – sequence: 6 givenname: Jinjun surname: Cheng fullname: Cheng, Jinjun – sequence: 7 givenname: Huihua surname: Qu fullname: Qu, Huihua – sequence: 8 givenname: Yan surname: Zhao fullname: Zhao, Yan
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31744056$$D View this record in MEDLINE/PubMed
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Copyright	2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 by the authors. 2019
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Keywords	carbon dots hyperuricemia new agents gouty uric acid Pueraria
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SubjectTerms	Animals Biocompatibility Biological activity Biopsy Carbon Carbon - chemistry carbon dots Cell Survival - drug effects Cytotoxicity Disease Models, Animal Drugs Gout - drug therapy Gout - etiology Gout - pathology Gout Suppressants - chemistry Gout Suppressants - pharmacology gouty hyperuricemia Mice Nanomaterials Nanoparticles - chemistry Nanoparticles - ultrastructure new agents Optical properties pueraria Pueraria - chemistry Quantum Dots - chemistry Quantum Dots - ultrastructure Rats RAW 264.7 Cells Rheumatism Spectrum Analysis Uric acid
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Title	Novel Carbon Dots Derived from Puerariae lobatae Radix and Their Anti-Gout Effects
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