A dandelion polysaccharide and its selenium nanoparticles: Structure features and evaluation of anti-tumor activity in zebrafish models

In this study, an inulin fructan (TMP50-2) with moderate anti-tumor activity was obtained from dandelion. To further improve the anti-tumor activity of TMP50-2, a monodisperse and stable spherical nanoparticle (Tw-TMP-SeNP, 50 nm) was fabricated. Physico-chemical analysis revealed that TMP50-2 and T...

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Veröffentlicht in:	Carbohydrate Polymers Jg. 270; S. 118365
Hauptverfasser:	Zhang, Shaojie, Song, Ziteng, Shi, Lijuan, Zhou, Linan, Zhang, Jie, Cui, Jianlin, Li, Yuhao, Jin, Da-Qing, Ohizumi, Yasushi, Xu, Jing, Guo, Yuanqiang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 15.10.2021 Elsevier BV
Schlagworte:	A549 Cells angiogenesis Animals Anti-tumor activity antineoplastic activity Antineoplastic Agents Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cell Proliferation Cell Proliferation - drug effects Danio rerio dose response Fructan Fructans Fructans - chemistry Fructans - pharmacology HeLa Cells Hep G2 Cells Humans hydrogen Hydrogen Bonding inulin Nanoparticles Nanoparticles - chemistry Neoplasms Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Polysaccharides Polysaccharides - chemistry Polysaccharides - pharmacology polysorbates Selenium Selenium - chemistry Selenium - pharmacology Selenium nanoparticles Taraxacum Taraxacum - chemistry Taraxacum mongolicum Hand.-Mazz Zebrafish Zebrafish Fructan Selenium nanoparticles Taraxacum mongolicum Hand.-Mazz Anti-tumor activity
ISSN:	0144-8617, 1879-1344, 1879-1344
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Abstract	In this study, an inulin fructan (TMP50-2) with moderate anti-tumor activity was obtained from dandelion. To further improve the anti-tumor activity of TMP50-2, a monodisperse and stable spherical nanoparticle (Tw-TMP-SeNP, 50 nm) was fabricated. Physico-chemical analysis revealed that TMP50-2 and Tween 80 were tightly wrapped on the surface of SeNPs by forming CO⋯Se bonds or through hydrogen bonding interaction (OH⋯Se). In vitro anti-tumor assay showed that Tw-TMP-SeNP treatment could significantly inhibit the proliferation of cancer cells (HepG2, A549, and HeLa) in a dose-dependent manner, while HepG2 cells were more susceptible to Tw-TMP-SeNP with an IC50 value of 46.8 μg/mL. The apoptosis induction of HepG2 cells by Tw-TMP-SeNP was evidenced by increasing the proportion of apoptotic cells ranging from 12.5% to 27.4%. Furthermore, in vivo zebrafish model confirmed the anti-tumor activity of Tw-TMP-SeNP by inhibiting the proliferation and migration of tumor cells as well as the angiogenesis of zebrafish embryos. •An inulin fructan, TMP50-2, was purified and characterized from dandelion.•A fructan-based nanoparticle (Tw-TMP-SeNP) was designed, fabricated, and characterized.•Tw-TMP-SeNP exerted anti-tumor activity by inducing apoptosis.•Tw-TMP-SeNP blocked tumor proliferation and migration in the zebrafish xenograft model.•Tw-TMP-SeNP inhibited angiogenesis in the transgenic zebrafish model.
AbstractList	In this study, an inulin fructan (TMP50-2) with moderate anti-tumor activity was obtained from dandelion. To further improve the anti-tumor activity of TMP50-2, a monodisperse and stable spherical nanoparticle (Tw-TMP-SeNP, 50 nm) was fabricated. Physico-chemical analysis revealed that TMP50-2 and Tween 80 were tightly wrapped on the surface of SeNPs by forming CO⋯Se bonds or through hydrogen bonding interaction (OH⋯Se). In vitro anti-tumor assay showed that Tw-TMP-SeNP treatment could significantly inhibit the proliferation of cancer cells (HepG2, A549, and HeLa) in a dose-dependent manner, while HepG2 cells were more susceptible to Tw-TMP-SeNP with an IC value of 46.8 μg/mL. The apoptosis induction of HepG2 cells by Tw-TMP-SeNP was evidenced by increasing the proportion of apoptotic cells ranging from 12.5% to 27.4%. Furthermore, in vivo zebrafish model confirmed the anti-tumor activity of Tw-TMP-SeNP by inhibiting the proliferation and migration of tumor cells as well as the angiogenesis of zebrafish embryos. In this study, an inulin fructan (TMP50-2) with moderate anti-tumor activity was obtained from dandelion. To further improve the anti-tumor activity of TMP50-2, a monodisperse and stable spherical nanoparticle (Tw-TMP-SeNP, 50 nm) was fabricated. Physico-chemical analysis revealed that TMP50-2 and Tween 80 were tightly wrapped on the surface of SeNPs by forming CO⋯Se bonds or through hydrogen bonding interaction (OH⋯Se). In vitro anti-tumor assay showed that Tw-TMP-SeNP treatment could significantly inhibit the proliferation of cancer cells (HepG2, A549, and HeLa) in a dose-dependent manner, while HepG2 cells were more susceptible to Tw-TMP-SeNP with an IC50 value of 46.8 μg/mL. The apoptosis induction of HepG2 cells by Tw-TMP-SeNP was evidenced by increasing the proportion of apoptotic cells ranging from 12.5% to 27.4%. Furthermore, in vivo zebrafish model confirmed the anti-tumor activity of Tw-TMP-SeNP by inhibiting the proliferation and migration of tumor cells as well as the angiogenesis of zebrafish embryos.In this study, an inulin fructan (TMP50-2) with moderate anti-tumor activity was obtained from dandelion. To further improve the anti-tumor activity of TMP50-2, a monodisperse and stable spherical nanoparticle (Tw-TMP-SeNP, 50 nm) was fabricated. Physico-chemical analysis revealed that TMP50-2 and Tween 80 were tightly wrapped on the surface of SeNPs by forming CO⋯Se bonds or through hydrogen bonding interaction (OH⋯Se). In vitro anti-tumor assay showed that Tw-TMP-SeNP treatment could significantly inhibit the proliferation of cancer cells (HepG2, A549, and HeLa) in a dose-dependent manner, while HepG2 cells were more susceptible to Tw-TMP-SeNP with an IC50 value of 46.8 μg/mL. The apoptosis induction of HepG2 cells by Tw-TMP-SeNP was evidenced by increasing the proportion of apoptotic cells ranging from 12.5% to 27.4%. Furthermore, in vivo zebrafish model confirmed the anti-tumor activity of Tw-TMP-SeNP by inhibiting the proliferation and migration of tumor cells as well as the angiogenesis of zebrafish embryos. In this study, an inulin fructan (TMP50-2) with moderate anti-tumor activity was obtained from dandelion. To further improve the anti-tumor activity of TMP50-2, a monodisperse and stable spherical nanoparticle (Tw-TMP-SeNP, 50 nm) was fabricated. Physico-chemical analysis revealed that TMP50-2 and Tween 80 were tightly wrapped on the surface of SeNPs by forming CO⋯Se bonds or through hydrogen bonding interaction (OH⋯Se). In vitro anti-tumor assay showed that Tw-TMP-SeNP treatment could significantly inhibit the proliferation of cancer cells (HepG2, A549, and HeLa) in a dose-dependent manner, while HepG2 cells were more susceptible to Tw-TMP-SeNP with an IC₅₀ value of 46.8 μg/mL. The apoptosis induction of HepG2 cells by Tw-TMP-SeNP was evidenced by increasing the proportion of apoptotic cells ranging from 12.5% to 27.4%. Furthermore, in vivo zebrafish model confirmed the anti-tumor activity of Tw-TMP-SeNP by inhibiting the proliferation and migration of tumor cells as well as the angiogenesis of zebrafish embryos. In this study, an inulin fructan (TMP50-2) with moderate anti-tumor activity was obtained from dandelion. To further improve the anti-tumor activity of TMP50-2, a monodisperse and stable spherical nanoparticle (Tw-TMP-SeNP, 50 nm) was fabricated. Physico-chemical analysis revealed that TMP50-2 and Tween 80 were tightly wrapped on the surface of SeNPs by forming CO⋯Se bonds or through hydrogen bonding interaction (OH⋯Se). In vitro anti-tumor assay showed that Tw-TMP-SeNP treatment could significantly inhibit the proliferation of cancer cells (HepG2, A549, and HeLa) in a dose-dependent manner, while HepG2 cells were more susceptible to Tw-TMP-SeNP with an IC50 value of 46.8 μg/mL. The apoptosis induction of HepG2 cells by Tw-TMP-SeNP was evidenced by increasing the proportion of apoptotic cells ranging from 12.5% to 27.4%. Furthermore, in vivo zebrafish model confirmed the anti-tumor activity of Tw-TMP-SeNP by inhibiting the proliferation and migration of tumor cells as well as the angiogenesis of zebrafish embryos. •An inulin fructan, TMP50-2, was purified and characterized from dandelion.•A fructan-based nanoparticle (Tw-TMP-SeNP) was designed, fabricated, and characterized.•Tw-TMP-SeNP exerted anti-tumor activity by inducing apoptosis.•Tw-TMP-SeNP blocked tumor proliferation and migration in the zebrafish xenograft model.•Tw-TMP-SeNP inhibited angiogenesis in the transgenic zebrafish model.
ArticleNumber	118365
Author	Jin, Da-Qing Xu, Jing Guo, Yuanqiang Song, Ziteng Zhang, Shaojie Zhou, Linan Cui, Jianlin Zhang, Jie Ohizumi, Yasushi Shi, Lijuan Li, Yuhao
Author_xml	– sequence: 1 givenname: Shaojie surname: Zhang fullname: Zhang, Shaojie organization: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China – sequence: 2 givenname: Ziteng surname: Song fullname: Song, Ziteng organization: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China – sequence: 3 givenname: Lijuan surname: Shi fullname: Shi, Lijuan organization: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China – sequence: 4 givenname: Linan surname: Zhou fullname: Zhou, Linan organization: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China – sequence: 5 givenname: Jie surname: Zhang fullname: Zhang, Jie organization: Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, People's Republic of China – sequence: 6 givenname: Jianlin surname: Cui fullname: Cui, Jianlin organization: School of Medicine, Nankai University, Tianjin 300071, People's Republic of China – sequence: 7 givenname: Yuhao surname: Li fullname: Li, Yuhao organization: School of Medicine, Nankai University, Tianjin 300071, People's Republic of China – sequence: 8 givenname: Da-Qing surname: Jin fullname: Jin, Da-Qing organization: School of Medicine, Nankai University, Tianjin 300071, People's Republic of China – sequence: 9 givenname: Yasushi surname: Ohizumi fullname: Ohizumi, Yasushi organization: Kansei Fukushi Research Institute, Tohoku Fukushi University, Sendai 989-3201, Japan – sequence: 10 givenname: Jing surname: Xu fullname: Xu, Jing email: xujing611@nankai.edu.cn organization: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China – sequence: 11 givenname: Yuanqiang surname: Guo fullname: Guo, Yuanqiang email: victgyq@nankai.edu.cn organization: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China
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Keywords	Zebrafish Fructan Selenium nanoparticles Taraxacum mongolicum Hand.-Mazz Anti-tumor activity
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Snippet	In this study, an inulin fructan (TMP50-2) with moderate anti-tumor activity was obtained from dandelion. To further improve the anti-tumor activity of...
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SubjectTerms	A549 Cells angiogenesis Animals Anti-tumor activity antineoplastic activity Antineoplastic Agents Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cell Proliferation Cell Proliferation - drug effects Danio rerio dose response Fructan Fructans Fructans - chemistry Fructans - pharmacology HeLa Cells Hep G2 Cells Humans hydrogen Hydrogen Bonding inulin Nanoparticles Nanoparticles - chemistry Neoplasms Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Polysaccharides Polysaccharides - chemistry Polysaccharides - pharmacology polysorbates Selenium Selenium - chemistry Selenium - pharmacology Selenium nanoparticles Taraxacum Taraxacum - chemistry Taraxacum mongolicum Hand.-Mazz Zebrafish
Title	A dandelion polysaccharide and its selenium nanoparticles: Structure features and evaluation of anti-tumor activity in zebrafish models
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