Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors

The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reaction. The nucleoside analogues (NA) hydroxyl functiona...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 27; no. 2; p. 564
Main Authors:	Manchoju, Amarender, Zelli, Renaud, Wang, Gang, Eymard, Carla, Oo, Adrian, Nemer, Mona, Prévost, Michel, Kim, Baek, Guindon, Yvan
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 17.01.2022 MDPI
Subjects:	Alcohol Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Carbon Carbon - chemistry Coronaviruses COVID-19 Enzymes epoxidation Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - pharmacology Laboratories nucleoside analogues Nucleotides - chemical synthesis Nucleotides - chemistry Nucleotides - pharmacology Phosphorylation quaternary stereocenter RdRp RNA polymerase RNA-Dependent RNA Polymerase - antagonists & inhibitors SARS-CoV-2 SARS-CoV-2 - drug effects SARS-CoV-2 - enzymology Severe acute respiratory syndrome coronavirus 2 Stereoisomerism Viruses COVID-19 SARS-CoV-2 epoxidation RdRp nucleoside analogues quaternary stereocenter glycosylation triphosphorylation
ISSN:	1420-3049, 1420-3049
Online Access:	Get full text
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