Novel therapies for metastatic castrate-resistant prostate cancer

Recent advances in tumor biology have made remarkable achievements in the development of therapy for metastatic castrate-resistant prostate cancer. These advances reflect a growing appreciation for the role of the tumor microenvironment in promoting prostate cancer progression. Prostate cancer is no...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute Jg. 103; H. 22; S. 1665
Hauptverfasser:	Dayyani, Farshid, Gallick, Gary E, Logothetis, Christopher J, Corn, Paul G
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 16.11.2011
Schlagworte:	Androstenes Androstenols - pharmacology Angiogenesis Inhibitors - pharmacology Anilides - pharmacology Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized - pharmacology Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Agents, Hormonal - pharmacology Atrasentan Bevacizumab Biomarkers, Tumor - blood Bone Remodeling - drug effects Cancer Vaccines - immunology Cancer Vaccines - pharmacology Clinical Trials as Topic Clusterin - pharmacology Dasatinib Denosumab Endothelin-1 - antagonists & inhibitors Humans Immunotherapy - methods Indoles - pharmacology Ipilimumab Male Mice Mice, SCID Molecular Targeted Therapy - methods Orchiectomy Phenylthiohydantoin - analogs & derivatives Phenylthiohydantoin - pharmacology Prostate-Specific Antigen - blood Prostatic Neoplasms - drug therapy Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Pyridines - pharmacology Pyrimidines - pharmacology Pyrroles - pharmacology Pyrrolidines - pharmacology RANK Ligand - antagonists & inhibitors RANK Ligand - pharmacology Receptor Cross-Talk - drug effects Receptors, Androgen - drug effects Signal Transduction - drug effects Sunitinib Taxoids - pharmacology Thiazoles - pharmacology Tissue Extracts - pharmacology Treatment Failure Tumor Microenvironment - drug effects Xenograft Model Antitumor Assays
ISSN:	1460-2105, 1460-2105
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