Single-Step Methylation of Chitosan Using Dimethyl Carbonate as a Green Methylating Agent

N,N,N-Trimethyl chitosan (TMC) is one chitosan derivative that, because of its improved solubility, has been studied for industrial and pharmaceutic applications. Conventional methods for the synthesis of TMC involve the use of highly toxic and harmful reagents, such as methyl iodide and dimethyl su...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Molecules (Basel, Switzerland) Ročník 24; číslo 21; s. 3986
Hlavní autori: Hemming, Ellen B., Masters, Anthony F., Perosa, Alvise, Selva, Maurizio, Maschmeyer, Thomas
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 04.11.2019
MDPI
Predmet:
Cellulose
Chitosan - chemistry
dimethyl carbonate
Formates - chemistry
green methylating agents
ionic liquids
Ionic Liquids - chemistry
n-methylation
Polymers
Reagents
Solvents
trimethyl chitosan
dimethyl carbonate
N-methylation
green methylating agents
ionic liquids
trimethyl chitosan
ISSN:1420-3049, 1420-3049
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:N,N,N-Trimethyl chitosan (TMC) is one chitosan derivative that, because of its improved solubility, has been studied for industrial and pharmaceutic applications. Conventional methods for the synthesis of TMC involve the use of highly toxic and harmful reagents, such as methyl iodide and dimethyl sulfate (DMS). Although the methylation of dimethylated chitosan to TMC by dimethyl carbonate (DMC, a green and benign methylating agent) was reported recently, it involved a formaldehyde-based procedure. In this paper we report the single-step synthesis of TMC from chitosan using DMC in an ionic liquid. The TMC synthesised was characterised by 1H NMR spectroscopy and a functionally meaningful degree of quaternisation of 9% was demonstrated after a 12-h reaction time.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24213986