Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta-analysis

Purpose: Aim of this study was to investigate the association between postdiagnosis body mass index (BMI) and all-cause mortality in colorectal cancer (CRC) survivors in a prospective study and meta-analysis. Methods: We conducted a prospective cohort study on 2,143 CRC survivors in Germany. Partici...

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Bibliographic Details
Published in:Cancer causes & control Vol. 25; no. 10; pp. 1407 - 1418
Main Authors: Schlesinger, Sabrina, Siegert, Sabine, Koch, Manja, Walter, Jessica, Heits, Nils, Hinz, Sebastian, Jacobs, Gunnar, Hampe, Jochen, Schafmayer, Clemens, Nöthlings, Ute
Format: Journal Article
Language:English
Published: Cham Springer 01.10.2014
Springer International Publishing
Springer Nature B.V
Subjects:
Aged
Alcohol drinking
Alcohol Drinking - epidemiology
Biobanks
Biomedical and Life Sciences
Biomedicine
Body Mass Index
Cancer
Cancer Research
Cause of Death
Cohort analysis
Cohort Studies
Colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - mortality
Comorbidity
Epidemiology
Female
Germany
Hematology
Hospitals
Humans
Incidence
Male
Medical research
Meta analysis
Middle Aged
Mortality
Obesity
Obesity - epidemiology
Oncology
Original Paper
Overweight
Overweight - epidemiology
Proportional Hazards Models
Prospective Studies
Public Health
Questionnaires
Risk Factors
Smoking - epidemiology
Surveys and Questionnaires
Survival Rate
Survivors - statistics & numerical data
Thinness - epidemiology
Thoracic surgery
Tobacco smoking
Underweight
Germany
Body mass index
Colorectal neoplasms
Mortality
Survivors
ISSN:0957-5243, 1573-7225, 1573-7225
Online Access:Get full text
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Summary:Purpose: Aim of this study was to investigate the association between postdiagnosis body mass index (BMI) and all-cause mortality in colorectal cancer (CRC) survivors in a prospective study and meta-analysis. Methods: We conducted a prospective cohort study on 2,143 CRC survivors in Germany. Participants were recruited to the study on average 4 years after diagnosis, and postdiagnosis BMI was assessed at recruitment using a self-administered questionnaire. CRC survivors were followed up for a mean time of 3.5 years. The association between BMI and all-cause mortality was investigated using multivariable Cox proportional hazards models. Additionally, we performed a meta-analysis of studies on postdiagnosis BMI and all-cause mortality (n = 5, including this study) by applying random-effects models. Results: In the prospective analysis, 349 participants died. BMI was not statistically significantly associated with all-cause mortality. Compared to normal weight survivors, the hazard ratios (HRs) [95 % confidence interval (CI)] for all-cause mortality in underweight, overweight and obese survivors were 1.65 (0.79–3.45), 0.80 (0.62–1.03) and 0.84 (0.62–1.14), respectively. In the meta-analysis, individuals with underweight were at increased risk for all-cause mortality [HR (95 % CI) 1.72 (1.18–2.49)], whereas individuals with overweight had a lower risk [HR (95 % CI) 0.79 (0.71–0.88)], compared to normal weight subjects. For obesity, the risk of mortality was also reduced with only borderline significance [HR (95 % CI) 0.88 (0.77–1.00)]. Conclusions: While the present study as well as single previously published studies showed that overweight was associated with a non-significant reduced risk for all-cause mortality, our meta-analysis indicated a decreased mortality risk among overweight CRC survivors.
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ISSN:0957-5243
1573-7225
1573-7225
DOI:10.1007/s10552-014-0435-x