Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)

The systemic capillary leak syndrome (SCLS) is a rare disorder characterized by transient episodes of hypotensive shock and anasarca thought to arise from reversible microvascular barrier dysfunction. Although the high prevalence of a monoclonal gammopathy of unknown significance in SCLS suggests a...

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Bibliographic Details
Published in:	Blood Vol. 119; no. 18; p. 4321
Main Authors:	Xie, Zhihui, Ghosh, Chandra C, Patel, Roshni, Iwaki, Shoko, Gaskins, Donna, Nelson, Celeste, Jones, Nina, Greipp, Philip R, Parikh, Samir M, Druey, Kirk M
Format:	Journal Article
Language:	English
Published:	United States 03.05.2012
Subjects:	Acute Disease Adherens Junctions - drug effects Adherens Junctions - ultrastructure Adult Aged Angiopoietin-2 - antagonists & inhibitors Angiopoietin-2 - blood Antibodies, Monoclonal, Humanized - pharmacology Apoptosis - drug effects Bevacizumab Capillary Leak Syndrome - blood Capillary Leak Syndrome - etiology Capillary Leak Syndrome - physiopathology Capillary Permeability Cells, Cultured - drug effects Chronic Disease Convalescence Cytoskeleton - ultrastructure Endothelial Cells - drug effects Endothelium, Vascular - physiopathology Female Humans Immunoglobulins, Intravenous - therapeutic use Male Middle Aged Paraproteinemias - blood Paraproteinemias - complications Recombinant Proteins - pharmacology Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - pharmacology
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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