Romanian Wormwood (Artemisia absinthium L.): Physicochemical and Nutraceutical Screening

Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. absinthium L. as well as the biological potential (antioxidan...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 24; no. 17; p. 3087
Main Authors: Moacă, Elena-Alina, Pavel, Ioana Zinuca, Danciu, Corina, Crăiniceanu, Zorin, Minda, Daliana, Ardelean, Florina, Antal, Diana Simona, Ghiulai, Roxana, Cioca, Andreea, Derban, Mihnea, Simu, Sebastian, Chioibaş, Raul, Szuhanek, Camelia, Dehelean, Cristina-Adriana
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 25.08.2019
MDPI
Subjects:
Acids
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Artemisia absinthium - chemistry
Artemisia absinthium L
Biological activity
Breast cancer
Calorimetry, Differential Scanning
Cell Line, Tumor
Cytotoxicity
Dietary Supplements - analysis
Drug Discovery
Free radicals
HaCaT cells
Humans
inflammation
Inhibitory Concentration 50
Investigations
Melanoma
melanoma and breast cancer cell line
Metabolites
Oils & fats
Phytochemicals - chemistry
Phytochemicals - pharmacology
Plant Extracts - chemistry
Plant Extracts - pharmacology
Spectrum Analysis
total phenolic content
Tumor necrosis factor-TNF
total phenolic content
HaCaT cells
antioxidants
inflammation
melanoma and breast cancer cell line
Artemisia absinthium L
cytotoxicity
ISSN:1420-3049, 1420-3049
Online Access:Get full text
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Summary:Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. absinthium L. as well as the biological potential (antioxidant activity, cytotoxic, anti-migratory and anti-inflammatory properties). Both plant materials showed quite similar thermogravimetric, FT-IR phenolic profile (high chlorogenic acid) with mild antioxidant capacity [ascorbic acid (0.02–0.1) > leaves (0.1–2.0) > stem (0.1–2.0)]. Alcoholic extracts from these plant materials showed a cytotoxic effect against A375 (melanoma) and MCF7 (breast adenocarcinoma) and affected less the non-malignant HaCaT cells (human keratinocytes) at 72 h post-stimulation and this same trend was observed in the anti-migratory (A375, MCF7 > HaCat) assay. Lastly, extracts ameliorated the pro-inflammatory effect of TPA (12-O-tetradecanoylphorbol-13-acetate) in mice ears, characterized by a diffuse neutrophil distribution with no exocytosis or micro-abscesses.
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These authors contributed equally to this work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24173087