Romanian Wormwood (Artemisia absinthium L.): Physicochemical and Nutraceutical Screening

Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. absinthium L. as well as the biological potential (antioxidan...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Jg. 24; H. 17; S. 3087
Hauptverfasser:	Moacă, Elena-Alina, Pavel, Ioana Zinuca, Danciu, Corina, Crăiniceanu, Zorin, Minda, Daliana, Ardelean, Florina, Antal, Diana Simona, Ghiulai, Roxana, Cioca, Andreea, Derban, Mihnea, Simu, Sebastian, Chioibaş, Raul, Szuhanek, Camelia, Dehelean, Cristina-Adriana
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 25.08.2019 MDPI
Schlagworte:	Acids Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Artemisia absinthium - chemistry Artemisia absinthium L Biological activity Breast cancer Calorimetry, Differential Scanning Cell Line, Tumor Cytotoxicity Dietary Supplements - analysis Drug Discovery Free radicals HaCaT cells Humans inflammation Inhibitory Concentration 50 Investigations Melanoma melanoma and breast cancer cell line Metabolites Oils & fats Phytochemicals - chemistry Phytochemicals - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Spectrum Analysis total phenolic content Tumor necrosis factor-TNF total phenolic content HaCaT cells antioxidants inflammation melanoma and breast cancer cell line Artemisia absinthium L cytotoxicity
ISSN:	1420-3049, 1420-3049
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Abstract	Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. absinthium L. as well as the biological potential (antioxidant activity, cytotoxic, anti-migratory and anti-inflammatory properties). Both plant materials showed quite similar thermogravimetric, FT-IR phenolic profile (high chlorogenic acid) with mild antioxidant capacity [ascorbic acid (0.02–0.1) > leaves (0.1–2.0) > stem (0.1–2.0)]. Alcoholic extracts from these plant materials showed a cytotoxic effect against A375 (melanoma) and MCF7 (breast adenocarcinoma) and affected less the non-malignant HaCaT cells (human keratinocytes) at 72 h post-stimulation and this same trend was observed in the anti-migratory (A375, MCF7 > HaCat) assay. Lastly, extracts ameliorated the pro-inflammatory effect of TPA (12-O-tetradecanoylphorbol-13-acetate) in mice ears, characterized by a diffuse neutrophil distribution with no exocytosis or micro-abscesses.
AbstractList	Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. absinthium L. as well as the biological potential (antioxidant activity, cytotoxic, anti-migratory and anti-inflammatory properties). Both plant materials showed quite similar thermogravimetric, FT-IR phenolic profile (high chlorogenic acid) with mild antioxidant capacity [ascorbic acid (0.02−0.1) > leaves (0.1−2.0) > stem (0.1−2.0)]. Alcoholic extracts from these plant materials showed a cytotoxic effect against A375 (melanoma) and MCF7 (breast adenocarcinoma) and affected less the non-malignant HaCaT cells (human keratinocytes) at 72 h post-stimulation and this same trend was observed in the anti-migratory (A375, MCF7 > HaCat) assay. Lastly, extracts ameliorated the pro-inflammatory effect of TPA (12-O-tetradecanoylphorbol-13-acetate) in mice ears, characterized by a diffuse neutrophil distribution with no exocytosis or micro-abscesses. Other secondary metabolites in wormwood include flavonoids (myricetin, quercetin, rutin, hesperidin), hydroxybenzoic acids (salicylic acid, gallic acid), hydroxycinnamic acids (caffeic acids, coumaric acids, ferulic acid), resveratrol, and other [7]. The current research aims to investigate in depth both the chemical composition as well as the biological activity of ethanolic extracts obtained from leaves and stems of wormwood collected from the Southern part of Romania in order to enhance the knowledge about the phytochemistry and bioactivity of this ancient medicinal plant with important medicinal potential. To this end, ethanol extracts of leaves and stems were investigated by liquid chromatography–mass spectrometry (LC-MS), thermal analysis (TG-DSC) and Fourier-transform infrared spectroscopy (FT-IR). [...]the AOA values of A. absinthium stem extract are slightly higher than the AOA values of A. absinthium leaves extract. Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. absinthium L. as well as the biological potential (antioxidant activity, cytotoxic, anti-migratory and anti-inflammatory properties). Both plant materials showed quite similar thermogravimetric, FT-IR phenolic profile (high chlorogenic acid) with mild antioxidant capacity [ascorbic acid (0.02-0.1) > leaves (0.1-2.0) > stem (0.1-2.0)]. Alcoholic extracts from these plant materials showed a cytotoxic effect against A375 (melanoma) and MCF7 (breast adenocarcinoma) and affected less the non-malignant HaCaT cells (human keratinocytes) at 72 h post-stimulation and this same trend was observed in the anti-migratory (A375, MCF7 > HaCat) assay. Lastly, extracts ameliorated the pro-inflammatory effect of TPA (12-o-tetradecanoylphorbol-13-acetate) in mice ears, characterized by a diffuse neutrophil distribution with no exocytosis or micro-abscesses.Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. absinthium L. as well as the biological potential (antioxidant activity, cytotoxic, anti-migratory and anti-inflammatory properties). Both plant materials showed quite similar thermogravimetric, FT-IR phenolic profile (high chlorogenic acid) with mild antioxidant capacity [ascorbic acid (0.02-0.1) > leaves (0.1-2.0) > stem (0.1-2.0)]. Alcoholic extracts from these plant materials showed a cytotoxic effect against A375 (melanoma) and MCF7 (breast adenocarcinoma) and affected less the non-malignant HaCaT cells (human keratinocytes) at 72 h post-stimulation and this same trend was observed in the anti-migratory (A375, MCF7 > HaCat) assay. Lastly, extracts ameliorated the pro-inflammatory effect of TPA (12-o-tetradecanoylphorbol-13-acetate) in mice ears, characterized by a diffuse neutrophil distribution with no exocytosis or micro-abscesses. Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. absinthium L. as well as the biological potential (antioxidant activity, cytotoxic, anti-migratory and anti-inflammatory properties). Both plant materials showed quite similar thermogravimetric, FT-IR phenolic profile (high chlorogenic acid) with mild antioxidant capacity [ascorbic acid (0.02–0.1) > leaves (0.1–2.0) > stem (0.1–2.0)]. Alcoholic extracts from these plant materials showed a cytotoxic effect against A375 (melanoma) and MCF7 (breast adenocarcinoma) and affected less the non-malignant HaCaT cells (human keratinocytes) at 72 h post-stimulation and this same trend was observed in the anti-migratory (A375, MCF7 > HaCat) assay. Lastly, extracts ameliorated the pro-inflammatory effect of TPA (12-O-tetradecanoylphorbol-13-acetate) in mice ears, characterized by a diffuse neutrophil distribution with no exocytosis or micro-abscesses. species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of L. as well as the biological potential (antioxidant activity, cytotoxic, anti-migratory and anti-inflammatory properties). Both plant materials showed quite similar thermogravimetric, FT-IR phenolic profile (high chlorogenic acid) with mild antioxidant capacity [ascorbic acid (0.02-0.1) > leaves (0.1-2.0) > stem (0.1-2.0)]. Alcoholic extracts from these plant materials showed a cytotoxic effect against A375 (melanoma) and MCF7 (breast adenocarcinoma) and affected less the non-malignant HaCaT cells (human keratinocytes) at 72 h post-stimulation and this same trend was observed in the anti-migratory (A375, MCF7 > HaCat) assay. Lastly, extracts ameliorated the pro-inflammatory effect of TPA (12-o-tetradecanoylphorbol-13-acetate) in mice ears, characterized by a diffuse neutrophil distribution with no exocytosis or micro-abscesses.
Author	Pavel, Ioana Zinuca Chioibaş, Raul Derban, Mihnea Antal, Diana Simona Crăiniceanu, Zorin Moacă, Elena-Alina Szuhanek, Camelia Danciu, Corina Ghiulai, Roxana Cioca, Andreea Minda, Daliana Dehelean, Cristina-Adriana Ardelean, Florina Simu, Sebastian
AuthorAffiliation	2 Department of Pharmacognosy, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania 1 Department of Toxicology and Drug Industry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania 7 Department of Physical Chemistry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania 4 Department of Botany, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania 8 CBS Medcom Hospital, 12 Popa Sapca Street, 300047 Timisoara, Romania 9 Department of Orthodontrics, Faculty of Dentistry, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timisoara, Romania 3 Department of Plastic and Reconstructive Surgery, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 3
AuthorAffiliation_xml	– name: 4 Department of Botany, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania – name: 3 Department of Plastic and Reconstructive Surgery, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania – name: 7 Department of Physical Chemistry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania – name: 9 Department of Orthodontrics, Faculty of Dentistry, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timisoara, Romania – name: 1 Department of Toxicology and Drug Industry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania – name: 2 Department of Pharmacognosy, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania – name: 6 Department of Pathology, CFR Clinical Hospital, 13-15, Tudor Vladimirescu, 300173 Timisoara, Romania – name: 8 CBS Medcom Hospital, 12 Popa Sapca Street, 300047 Timisoara, Romania – name: 5 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
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Keywords	total phenolic content HaCaT cells antioxidants inflammation melanoma and breast cancer cell line Artemisia absinthium L cytotoxicity
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Snippet	Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the... species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical... Other secondary metabolites in wormwood include flavonoids (myricetin, quercetin, rutin, hesperidin), hydroxybenzoic acids (salicylic acid, gallic acid),...
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SubjectTerms	Acids Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Artemisia absinthium - chemistry Artemisia absinthium L Biological activity Breast cancer Calorimetry, Differential Scanning Cell Line, Tumor Cytotoxicity Dietary Supplements - analysis Drug Discovery Free radicals HaCaT cells Humans inflammation Inhibitory Concentration 50 Investigations Melanoma melanoma and breast cancer cell line Metabolites Oils & fats Phytochemicals - chemistry Phytochemicals - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Spectrum Analysis total phenolic content Tumor necrosis factor-TNF
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Title	Romanian Wormwood (Artemisia absinthium L.): Physicochemical and Nutraceutical Screening
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