An LC/MS/MS method for stable isotope dilution studies of β-carotene bioavailability, bioconversion, and vitamin A status in humans

Isotope dilution is currently the most accurate technique in humans to determine vitamin A status and bioavailability/bioconversion of provitamin A carotenoids such as β-carotene. However, limits of MS detection, coupled with extensive isolation procedures, have hindered investigations of physiologi...

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Bibliographic Details
Published in:	Journal of lipid research Vol. 55; no. 2; pp. 319 - 328
Main Authors:	Oxley, Anthony, Berry, Philip, Taylor, Gordon A, Cowell, Joseph, Hall, Michael J, Hesketh, John, Lietz, Georg, Boddy, Alan V
Format:	Journal Article
Language:	English
Published:	United States Elsevier 01.02.2014
Subjects:	Adolescent Adult beta Carotene - blood beta Carotene - metabolism beta Carotene - pharmacokinetics Biological Availability Biotransformation carotenoid metabolism Chromatography, Liquid - methods Female Humans Isotopes Male Middle Aged retinol metabolism retinyl esters tandem mass spectrometry Tandem Mass Spectrometry - methods Time Factors Vitamin A - blood Vitamin A - metabolism Young Adult β-carotene 15,15′-monooxygenase tandem mass spectrometry retinyl esters carotenoid metabolism retinol metabolism β-carotene 15,15′-monooxygenase
ISSN:	1539-7262, 0022-2275, 1539-7262
Online Access:	Get full text
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