Important Flavonoids and Their Role as a Therapeutic Agent
Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuropr...
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| Vydané v: | Molecules (Basel, Switzerland) Ročník 25; číslo 22; s. 5243 |
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| Hlavní autori: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Switzerland
MDPI AG
11.11.2020
MDPI |
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| ISSN: | 1420-3049, 1420-3049 |
| On-line prístup: | Získať plný text |
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| Abstract | Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health. |
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| AbstractList | Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health. Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health. |
| Author | Munir, Sidra Emwas, Abdul-Hamid Badshah, Syed Lal Poulson, Benjamin Gabriel Ghani, Lubna Khan, Noreen Jaremko, Mariusz Ullah, Asad |
| AuthorAffiliation | 1 Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan; asad_icp@yahoo.com (A.U.); saries92@gmail.com (S.M.); noreenkhattak777@gmail.com (N.K.) 3 Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia; benjamingabriel.poulson@kaust.edu.sa 4 Core Labs, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia; abdelhamid.emwas@kaust.edu.sa 2 Department of Chemistry, The University of Azad Jammu and Kashmir, Muzaffarabad, Azad Kashmir 13230, Pakistan; lubnaghani41@gmail.com |
| AuthorAffiliation_xml | – name: 4 Core Labs, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia; abdelhamid.emwas@kaust.edu.sa – name: 2 Department of Chemistry, The University of Azad Jammu and Kashmir, Muzaffarabad, Azad Kashmir 13230, Pakistan; lubnaghani41@gmail.com – name: 3 Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia; benjamingabriel.poulson@kaust.edu.sa – name: 1 Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan; asad_icp@yahoo.com (A.U.); saries92@gmail.com (S.M.); noreenkhattak777@gmail.com (N.K.) |
| Author_xml | – sequence: 1 givenname: Asad orcidid: 0000-0002-0142-8565 surname: Ullah fullname: Ullah, Asad – sequence: 2 givenname: Sidra orcidid: 0000-0002-0976-0554 surname: Munir fullname: Munir, Sidra – sequence: 3 givenname: Syed Lal orcidid: 0000-0002-0229-1425 surname: Badshah fullname: Badshah, Syed Lal – sequence: 4 givenname: Noreen surname: Khan fullname: Khan, Noreen – sequence: 5 givenname: Lubna surname: Ghani fullname: Ghani, Lubna – sequence: 6 givenname: Benjamin Gabriel orcidid: 0000-0001-8149-9023 surname: Poulson fullname: Poulson, Benjamin Gabriel – sequence: 7 givenname: Abdul-Hamid orcidid: 0000-0002-9231-3850 surname: Emwas fullname: Emwas, Abdul-Hamid – sequence: 8 givenname: Mariusz surname: Jaremko fullname: Jaremko, Mariusz |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33187049$$D View this record in MEDLINE/PubMed |
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| Keywords | polyphenols quercetin antioxidative flavonoids neuroprotective |
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| SubjectTerms | Alzheimer Disease - drug therapy Alzheimer Disease - prevention & control Angiogenesis Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antifungal Agents - chemistry Antifungal Agents - pharmacology Antimalarials - chemistry Antimalarials - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidants Antioxidants - chemistry Antioxidants - pharmacology antioxidative Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral drugs Breast cancer Cancer therapies Cardiovascular System - drug effects Cell cycle Cell growth Colorectal cancer Cytotoxicity Drug dosages Flavonoids Flavonoids - chemistry Flavonoids - economics Flavonoids - pharmacology Fruits Humans Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Kinases Liver cancer Metabolism Metabolites Mice Nanoparticles Nervous System - drug effects Neurons - drug effects neuroprotective Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Phytochemicals Plant Extracts - pharmacology Plant Leaves - chemistry Plants - chemistry Polyphenols Polyphenols - chemistry Polyphenols - pharmacology quercetin Quercetin - chemistry Quercetin - pharmacology Rats Rats, Sprague-Dawley Rats, Wistar Review Stroke - drug therapy Stroke - prevention & control Vascular endothelial growth factor |
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| Title | Important Flavonoids and Their Role as a Therapeutic Agent |
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