Fat mass to fat-free mass ratio and its associations with clinical characteristics in asthma

•FM/FFM is associated with different clinical outcomes (factors) in adults with asthma.•Factors are corticosteroids, medication steps, lung function and physical activity.•Those with higher FM/FFM are more likely to be in stages 4–5 and physically inactive. Fat mass to fat-free mass ratio (FM/FFM) a...

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Vydáno v:	Heart & lung Ročník 56; s. 154 - 160
Hlavní autoři:	Rugila, Diery Fernandes, Oliveira, Joice Mara, Machado, Felipe Vilaça Cavallari, Correia, Natielly Soares, Puzzi, Vitória Cavalheiro, Passos, Natália Febrini Piassi, Freitas, Patrícia Duarte, Pitta, Fabio, Carvalho, Celso Ricardo Fernandes, Furlanetto, Karina Couto
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Elsevier Inc 01.11.2022
Témata:	ACQ, Asthma Control Questionnaire AQLQ, Asthma Quality of Life Questionnaire Asthma BMI, Body mass index Body composition Cardiovascular Critical Care Drug therapy FEV1, Forced expiratory volume in the first second FEV1/FVC, Forced expiratory volume in the first second to forced vital capacity ratio FFM, Fat-free mass FM, Fat mass FM/FFM, Fat mass to fat-free mass ratio FVC, Forced vital capacity GINA, Global Initiative for Asthma HADS, Hospital Anxiety and Depression Scale Motor activity PADL, Physical Activity in Daily Life Pulmonary/Respiratory Respiratory function tests AQLQ, Asthma Quality of Life Questionnaire FEV1, Forced expiratory volume in the first second Motor activity BMI, Body mass index HADS, Hospital Anxiety and Depression Scale Body composition FVC, Forced vital capacity Asthma FFM, Fat-free mass PADL, Physical Activity in Daily Life ACQ, Asthma Control Questionnaire FM/FFM, Fat mass to fat-free mass ratio FEV1/FVC, Forced expiratory volume in the first second to forced vital capacity ratio FM, Fat mass GINA, Global Initiative for Asthma Drug therapy Respiratory function tests FEV 1/FVC, Forced expiratory volume in the first second to forced vital capacity ratio FEV 1, Forced expiratory volume in the first second
ISSN:	0147-9563, 1527-3288, 1527-3288
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Shrnutí:	•FM/FFM is associated with different clinical outcomes (factors) in adults with asthma.•Factors are corticosteroids, medication steps, lung function and physical activity.•Those with higher FM/FFM are more likely to be in stages 4–5 and physically inactive. Fat mass to fat-free mass ratio (FM/FFM) assesses the combined effect of the balance between fat mass and fat-free mass. Aims: to evaluate the associations beetween FM/FFM and clinical outcomes in asthma and to compare clinical characteristics between individuals with higher and lower FM/FFM. 128 participants with asthma underwent anthropometric, spirometry and bioelectrical impedance assessments. Physical activity in daily life (PADL) was assessed by the Actigraph for 7 days. Daily dose of inhaled medication, steps of pharmacological treatment, Asthma Control Questionnaire, Asthma Quality of Life Questionnaire and Hospital Anxiety and Depression Scale were also assessed. Participants were classified into two groups according to the 50th percentile of reference values for FM/FFM. Individuals with higher FM/FFM (n=75) used higher daily doses of inhaled corticosteroids, had worse lung function and fewer steps/day when compared to those with lower FM/FFM (n=53) (P≤0.021). Associations were found between absolute values of FM/FFM with lung function (FEV1 and FVC [liters]): R2=0.207 and 0.364;P<0.0001), and between the categories of lower or higher FM/FFM with steps of medication treatment (Cramer's V=0.218;P=0.016) and level of PADL (Cramer's V=0.236;P=0.009). The highest FM/FFM was a determining factor of physical inactivity (OR: 3.21;95%CI:1.17–8.78) and highest steps of pharmacological treatment (OR: 8.89;95%CI:1.23–64.08). Higher FM/FFM is significantly associated with worse clinical characteristics in individuals with asthma, such as higher doses of inhaled corticosteroids, worse lung function and fewer steps/day. Moreover, higher FM/FFM is a determining factor of physical inactivity and the highest steps of pharmacological treatment for asthma.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0147-9563 1527-3288 1527-3288
DOI:	10.1016/j.hrtlng.2022.07.006