Trends in Next-Generation Sequencing and a New Era for Whole Genome Sequencing

This article is a mini-review that provides a general overview for next-generation sequencing (NGS) and introduces one of the most popular NGS applications, whole genome sequencing (WGS), developed from the expansion of human genomics. NGS technology has brought massively high throughput sequencing...

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Vydáno v:International neurourology journal Ročník 20; číslo Suppl 2; s. S76 - 83
Hlavní autoři: Park, Sang Tae, Kim, Jayoung
Médium: Journal Article
Jazyk:angličtina
Vydáno: Korea (South) Korean Continence Society 01.11.2016
대한배뇨장애요실금학회
Témata:
Epigenomics
Genomics
High-Throughput Nucleotide Sequencing
Human Genome Project
Review
Sequence Analysis, RNA
비뇨기과학
High-Throughput Nucleotide Sequencing
Epigenomics
Sequence Analysis, RNA
Human Genome Project
Genomics
ISSN:2093-6931, 2093-4777, 2093-6931
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Shrnutí:This article is a mini-review that provides a general overview for next-generation sequencing (NGS) and introduces one of the most popular NGS applications, whole genome sequencing (WGS), developed from the expansion of human genomics. NGS technology has brought massively high throughput sequencing data to bear on research questions, enabling a new era of genomic research. Development of bioinformatic software for NGS has provided more opportunities for researchers to use various applications in genomic fields. genome assembly and large scale DNA resequencing to understand genomic variations are popular genomic research tools for processing a tremendous amount of data at low cost. Studies on transcriptomes are now available, from previous-hybridization based microarray methods. Epigenetic studies are also available with NGS applications such as whole genome methylation sequencing and chromatin immunoprecipitation followed by sequencing. Human genetics has faced a new paradigm of research and medical genomics by sequencing technologies since the Human Genome Project. The trend of NGS technologies in human genomics has brought a new era of WGS by enabling the building of human genomes databases and providing appropriate human reference genomes, which is a necessary component of personalized medicine and precision medicine.
Bibliografie:ObjectType-Article-2
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G704-001728.2016.20..017
ISSN:2093-6931
2093-4777
2093-6931
DOI:10.5213/inj.1632742.371