Large-scale independent validation of the nuclear factor-kappa B p65 prognostic biomarker in prostate cancer

Over the last decade, we and others have uncovered a robust association between the nuclear localisation of nuclear factor-kappa B (NF-κB) p65, prostate cancer (PCa) aggressiveness and biochemical recurrence (BCR). Our goal was to validate these results in a large independent cohort of PCa patients...

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Bibliographic Details
Published in:	European journal of cancer (1990) Vol. 49; no. 10; pp. 2441 - 2448
Main Authors:	Gannon, Philippe O., Lessard, Laurent, Stevens, Louis-Mathieu, Forest, Valérie, Bégin, Louis R., Minner, Sarah, Tennstedt, Pierre, Schlomm, Thorsten, Mes-Masson, Anne-Marie, Saad, Fred
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 01.07.2013 Elsevier
Subjects:	Aged Biochemical recurrence Biological and medical sciences Biological marker Biomarkers, Tumor - analysis Cell Nucleus - metabolism Cohort Studies Disease Progression Disease-Free Survival Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Immunohistochemistry - statistics & numerical data Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Multivariate Analysis Neoplasm Recurrence, Local Nuclear factor-kappa B (NF-κB) Pharmacology. Drug treatments Prognosis Proportional Hazards Models Prostate - metabolism Prostate - pathology Prostate - surgery Prostate-Specific Antigen - analysis Prostatectomy - methods Prostatic Neoplasms - diagnosis Prostatic Neoplasms - metabolism Prostatic Neoplasms - surgery Seminal Vesicles - metabolism Seminal Vesicles - pathology Sensitivity and Specificity Severity of Illness Index Tissue Array Analysis - statistics & numerical data Transcription Factor RelA - analysis Tumors Immunohistochemistry Biological marker Nuclear factor-kappa B (NF-κB) Biochemical recurrence Validation Urinary system disease Prognosis Prostate disease Malignant tumor Anatomic pathology Cancerology Transcription factor NFκB Male genital diseases Prostate cancer Cancer
ISSN:	0959-8049, 1879-0852, 1879-0852
Online Access:	Get full text
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