Simultaneous selection of multiple important single nucleotide polymorphisms in familial genome wide association studies data

We propose a resampling-based fast variable selection technique for detecting relevant single nucleotide polymorphisms (SNP) in a multi-marker mixed effect model. Due to computational complexity, current practice primarily involves testing the effect of one SNP at a time, commonly termed as ‘single...

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Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; pp. 8476 - 13
Main Authors:	Majumdar, Subhabrata, Basu, Saonli, McGue, Matt, Chatterjee, Snigdhansu
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.05.2023 Nature Publishing Group Nature Portfolio
Subjects:	631/208/205/2138 639/705/531 Alcohol Alcohol Drinking Association analysis Computer applications Datasets Feature selection Generation X Genetic analysis Genetic diversity Genetic variance Genome-wide association studies Genome-Wide Association Study - methods Genomes Humanities and Social Sciences Humans Hypotheses Hypothesis testing Information processing Methods Minnesota Models, Genetic multidisciplinary Phenotype Polymorphism, Single Nucleotide Sample size Science Science (multidisciplinary) Single-nucleotide polymorphism Twins Minnesota
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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