Choroidal thickness under pilocarpine versus cyclopentolate

Bruch´s membrane (BM) is firmly connected posteriorly to the optic nerve head through the peripapillary choroidal border tissue, and anteriorly through the longitudinal ciliary muscle to the scleral spur. We assessed, whether a difference in the contractile state of the ciliary muscle influences the...

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Bibliographic Details
Published in:Scientific reports Vol. 15; no. 1; pp. 2221 - 7
Main Authors: Bikbov, Mukharram M., Kazakbaeva, Gyulli M., Panda-Jonas, Songhomitra, Mustafina, Gulshat R., Jonas, Jost B.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 17.01.2025
Nature Publishing Group
Nature Portfolio
Subjects:
692/308/1426
692/308/2056
Adolescent
Adult
Axial elongation
Axial myopia
Biometrics
Bruch Membrane - drug effects
Choroid - anatomy & histology
Choroid - diagnostic imaging
Choroid - drug effects
Choroidal thickness
Ciliary muscle
Cyclopentolate - administration & dosage
Cyclopentolate - pharmacology
Eye
Female
Humanities and Social Sciences
Humans
Male
multidisciplinary
Muscle contraction
Myopia
Normal distribution
Ophthalmology
Optic nerve
Optics
Pilocarpine
Pilocarpine - administration & dosage
Pilocarpine - pharmacology
Research centers
Science
Science (multidisciplinary)
Standard deviation
Statistical analysis
Tomography
Tomography, Optical Coherence
Young Adult
Young adults
Axial myopia
Choroidal thickness
333
Axial elongation
Ciliary muscle
Myopia
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Bruch´s membrane (BM) is firmly connected posteriorly to the optic nerve head through the peripapillary choroidal border tissue, and anteriorly through the longitudinal ciliary muscle to the scleral spur. We assessed, whether a difference in the contractile state of the ciliary muscle influences the position of the posterior BM by lifting the posterior BM pole, i.e., induces changes in the subfoveal choroidal thickness (SFCT). Healthy young adult individuals received one drop of cyclopentolate 1% into their right eyes and one drop of pilocarpine 1% into their left eyes. Using optical coherence tomography (OCT), three examiners measured independently SFCT and choroidal thickness in the fundus midperiphery at baseline and 30 min after eye drop instillation. The study included 21 healthy individuals (age:21.9 ± 2.6 years; range:15.7–25.8 years; axial length:24.4 ± 1.2 mm). In the right eyes, SFCT changed by 8.7 ± 34.9 μm (examiner 1), -2.9 ± 18.6 μm (examiner 2), and 10.5 ± 21.8 μm (examiner 3), respectively, and the midperipheral choroidal thickness changed by -10.6 ± 25.9 μm (examiner 1), 0.9 ± 17.5 μm (examiner 2), and 4.2 ± 24.7 μm (examiner 3), respectively, without significant differences between the measurements taken before and after eye drop application (all P  > 0.05). In the left eyes, SFCT changed by 5.8 ± 22.2 μm (examiner 1), 5.5 ± 36.5 μm (examiner 2), and 3.9 ± 29.5 μm (examiner 3), respectively, and the midperipheral choroidal thickness changed by -6.9 ± 47.9 μm (examiner 1), -3.5 ± 28.7 μm (examiner 2), and 16.0 ± 28.2 μm (examiner3), respectively, without significant differences between baseline and study end (all P  > 0.05). Application of cyclopentolate 1% and of pilocarpine 1% did not result in a statistically significant change in choroidal thickness in young healthy adults.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-025-85712-w