Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo

Platelets play a central role in thrombosis, hemostasis, and inflammation. We show that activated platelets release inorganic polyphosphate (polyP), a polymer of 60-100 phosphate residues that directly bound to and activated the plasma protease factor XII. PolyP-driven factor XII activation triggere...

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Bibliographic Details

Published in:	Cell Vol. 139; no. 6; p. 1143
Main Authors:	Müller, Felicitas, Mutch, Nicola J, Schenk, Wolfdieter A, Smith, Stephanie A, Esterl, Lucie, Spronk, Henri M, Schmidbauer, Stefan, Gahl, William A, Morrissey, James H, Renné, Thomas
Format:	Journal Article
Language:	English
Published:	United States 11.12.2009
Subjects:	Animals Blood Platelets - metabolism Bradykinin - metabolism Factor XII - genetics Factor XII - metabolism Fibrin - metabolism Hermanski-Pudlak Syndrome - metabolism Humans Inflammation Mediators - metabolism Mice Peptide Hydrolases - metabolism Plasma Polyphosphates - metabolism Receptors, Bradykinin - metabolism Thrombosis - metabolism
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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