Generation of short-term follow-up chest CT images using a latent diffusion model in COVID-19

Purpose Despite a global decrease in the number of COVID-19 patients, early prediction of the clinical course for optimal patient care remains challenging. Recently, the usefulness of image generation for medical images has been investigated. This study aimed to generate short-term follow-up chest C...

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Vydáno v:	Japanese journal of radiology Ročník 43; číslo 4; s. 622 - 633
Hlavní autoři:	Kawata, Naoko, Iwao, Yuma, Matsuura, Yukiko, Higashide, Takashi, Okamoto, Takayuki, Sekiguchi, Yuki, Nagayoshi, Masaru, Takiguchi, Yasuo, Suzuki, Takuji, Haneishi, Hideaki
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Singapore Springer Nature Singapore 01.04.2025 Springer Nature B.V
Témata:	Adult Aged Chest Coders Computed tomography COVID-19 COVID-19 - diagnostic imaging Cross correlation Diffusion Diffusion models Female Follow-Up Studies Humans Image processing Imaging Lung - diagnostic imaging Male Medical imaging Medicine Medicine & Public Health Middle Aged Nuclear Medicine Original Original Article Parameters Patients Pneumonia Radiographic Image Interpretation, Computer-Assisted - methods Radiography, Thoracic - methods Radiology Radiomics Radiotherapy Respiratory diseases Retrospective Studies SARS-CoV-2 Signal to noise ratio Similarity Tomography, X-Ray Computed - methods Training COVID-19 Deep learning Chest CT images Prognostic image generation Latent diffusion model
ISSN:	1867-1071, 1867-108X, 1867-108X
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Abstract	Purpose Despite a global decrease in the number of COVID-19 patients, early prediction of the clinical course for optimal patient care remains challenging. Recently, the usefulness of image generation for medical images has been investigated. This study aimed to generate short-term follow-up chest CT images using a latent diffusion model in patients with COVID-19. Materials and methods We retrospectively enrolled 505 patients with COVID-19 for whom the clinical parameters (patient background, clinical symptoms, and blood test results) upon admission were available and chest CT imaging was performed. Subject datasets ( n = 505) were allocated for training ( n = 403), and the remaining ( n = 102) were reserved for evaluation. The image underwent variational autoencoder (VAE) encoding, resulting in latent vectors. The information consisting of initial clinical parameters and radiomic features were formatted as a table data encoder. Initial and follow-up latent vectors and the initial table data encoders were utilized for training the diffusion model. The evaluation data were used to generate prognostic images. Then, similarity of the prognostic images (generated images) and the follow-up images (real images) was evaluated by zero-mean normalized cross-correlation (ZNCC), peak signal-to-noise ratio (PSNR), and structural similarity (SSIM). Visual assessment was also performed using a numerical rating scale. Results Prognostic chest CT images were generated using the diffusion model. Image similarity showed reasonable values of 0.973 ± 0.028 for the ZNCC, 24.48 ± 3.46 for the PSNR, and 0.844 ± 0.075 for the SSIM. Visual evaluation of the images by two pulmonologists and one radiologist yielded a reasonable mean score. Conclusions The similarity and validity of generated predictive images for the course of COVID-19-associated pneumonia using a diffusion model were reasonable. The generation of prognostic images may suggest potential utility for early prediction of the clinical course in COVID-19-associated pneumonia and other respiratory diseases.
AbstractList	Purpose Despite a global decrease in the number of COVID-19 patients, early prediction of the clinical course for optimal patient care remains challenging. Recently, the usefulness of image generation for medical images has been investigated. This study aimed to generate short-term follow-up chest CT images using a latent diffusion model in patients with COVID-19. Materials and methods We retrospectively enrolled 505 patients with COVID-19 for whom the clinical parameters (patient background, clinical symptoms, and blood test results) upon admission were available and chest CT imaging was performed. Subject datasets ( n = 505) were allocated for training ( n = 403), and the remaining ( n = 102) were reserved for evaluation. The image underwent variational autoencoder (VAE) encoding, resulting in latent vectors. The information consisting of initial clinical parameters and radiomic features were formatted as a table data encoder. Initial and follow-up latent vectors and the initial table data encoders were utilized for training the diffusion model. The evaluation data were used to generate prognostic images. Then, similarity of the prognostic images (generated images) and the follow-up images (real images) was evaluated by zero-mean normalized cross-correlation (ZNCC), peak signal-to-noise ratio (PSNR), and structural similarity (SSIM). Visual assessment was also performed using a numerical rating scale. Results Prognostic chest CT images were generated using the diffusion model. Image similarity showed reasonable values of 0.973 ± 0.028 for the ZNCC, 24.48 ± 3.46 for the PSNR, and 0.844 ± 0.075 for the SSIM. Visual evaluation of the images by two pulmonologists and one radiologist yielded a reasonable mean score. Conclusions The similarity and validity of generated predictive images for the course of COVID-19-associated pneumonia using a diffusion model were reasonable. The generation of prognostic images may suggest potential utility for early prediction of the clinical course in COVID-19-associated pneumonia and other respiratory diseases. PurposeDespite a global decrease in the number of COVID-19 patients, early prediction of the clinical course for optimal patient care remains challenging. Recently, the usefulness of image generation for medical images has been investigated. This study aimed to generate short-term follow-up chest CT images using a latent diffusion model in patients with COVID-19.Materials and methodsWe retrospectively enrolled 505 patients with COVID-19 for whom the clinical parameters (patient background, clinical symptoms, and blood test results) upon admission were available and chest CT imaging was performed. Subject datasets (n = 505) were allocated for training (n = 403), and the remaining (n = 102) were reserved for evaluation. The image underwent variational autoencoder (VAE) encoding, resulting in latent vectors. The information consisting of initial clinical parameters and radiomic features were formatted as a table data encoder. Initial and follow-up latent vectors and the initial table data encoders were utilized for training the diffusion model. The evaluation data were used to generate prognostic images. Then, similarity of the prognostic images (generated images) and the follow-up images (real images) was evaluated by zero-mean normalized cross-correlation (ZNCC), peak signal-to-noise ratio (PSNR), and structural similarity (SSIM). Visual assessment was also performed using a numerical rating scale.ResultsPrognostic chest CT images were generated using the diffusion model. Image similarity showed reasonable values of 0.973 ± 0.028 for the ZNCC, 24.48 ± 3.46 for the PSNR, and 0.844 ± 0.075 for the SSIM. Visual evaluation of the images by two pulmonologists and one radiologist yielded a reasonable mean score.ConclusionsThe similarity and validity of generated predictive images for the course of COVID-19-associated pneumonia using a diffusion model were reasonable. The generation of prognostic images may suggest potential utility for early prediction of the clinical course in COVID-19-associated pneumonia and other respiratory diseases. Despite a global decrease in the number of COVID-19 patients, early prediction of the clinical course for optimal patient care remains challenging. Recently, the usefulness of image generation for medical images has been investigated. This study aimed to generate short-term follow-up chest CT images using a latent diffusion model in patients with COVID-19.PURPOSEDespite a global decrease in the number of COVID-19 patients, early prediction of the clinical course for optimal patient care remains challenging. Recently, the usefulness of image generation for medical images has been investigated. This study aimed to generate short-term follow-up chest CT images using a latent diffusion model in patients with COVID-19.We retrospectively enrolled 505 patients with COVID-19 for whom the clinical parameters (patient background, clinical symptoms, and blood test results) upon admission were available and chest CT imaging was performed. Subject datasets (n = 505) were allocated for training (n = 403), and the remaining (n = 102) were reserved for evaluation. The image underwent variational autoencoder (VAE) encoding, resulting in latent vectors. The information consisting of initial clinical parameters and radiomic features were formatted as a table data encoder. Initial and follow-up latent vectors and the initial table data encoders were utilized for training the diffusion model. The evaluation data were used to generate prognostic images. Then, similarity of the prognostic images (generated images) and the follow-up images (real images) was evaluated by zero-mean normalized cross-correlation (ZNCC), peak signal-to-noise ratio (PSNR), and structural similarity (SSIM). Visual assessment was also performed using a numerical rating scale.MATERIALS AND METHODSWe retrospectively enrolled 505 patients with COVID-19 for whom the clinical parameters (patient background, clinical symptoms, and blood test results) upon admission were available and chest CT imaging was performed. Subject datasets (n = 505) were allocated for training (n = 403), and the remaining (n = 102) were reserved for evaluation. The image underwent variational autoencoder (VAE) encoding, resulting in latent vectors. The information consisting of initial clinical parameters and radiomic features were formatted as a table data encoder. Initial and follow-up latent vectors and the initial table data encoders were utilized for training the diffusion model. The evaluation data were used to generate prognostic images. Then, similarity of the prognostic images (generated images) and the follow-up images (real images) was evaluated by zero-mean normalized cross-correlation (ZNCC), peak signal-to-noise ratio (PSNR), and structural similarity (SSIM). Visual assessment was also performed using a numerical rating scale.Prognostic chest CT images were generated using the diffusion model. Image similarity showed reasonable values of 0.973 ± 0.028 for the ZNCC, 24.48 ± 3.46 for the PSNR, and 0.844 ± 0.075 for the SSIM. Visual evaluation of the images by two pulmonologists and one radiologist yielded a reasonable mean score.RESULTSPrognostic chest CT images were generated using the diffusion model. Image similarity showed reasonable values of 0.973 ± 0.028 for the ZNCC, 24.48 ± 3.46 for the PSNR, and 0.844 ± 0.075 for the SSIM. Visual evaluation of the images by two pulmonologists and one radiologist yielded a reasonable mean score.The similarity and validity of generated predictive images for the course of COVID-19-associated pneumonia using a diffusion model were reasonable. The generation of prognostic images may suggest potential utility for early prediction of the clinical course in COVID-19-associated pneumonia and other respiratory diseases.CONCLUSIONSThe similarity and validity of generated predictive images for the course of COVID-19-associated pneumonia using a diffusion model were reasonable. The generation of prognostic images may suggest potential utility for early prediction of the clinical course in COVID-19-associated pneumonia and other respiratory diseases. Despite a global decrease in the number of COVID-19 patients, early prediction of the clinical course for optimal patient care remains challenging. Recently, the usefulness of image generation for medical images has been investigated. This study aimed to generate short-term follow-up chest CT images using a latent diffusion model in patients with COVID-19. We retrospectively enrolled 505 patients with COVID-19 for whom the clinical parameters (patient background, clinical symptoms, and blood test results) upon admission were available and chest CT imaging was performed. Subject datasets (n = 505) were allocated for training (n = 403), and the remaining (n = 102) were reserved for evaluation. The image underwent variational autoencoder (VAE) encoding, resulting in latent vectors. The information consisting of initial clinical parameters and radiomic features were formatted as a table data encoder. Initial and follow-up latent vectors and the initial table data encoders were utilized for training the diffusion model. The evaluation data were used to generate prognostic images. Then, similarity of the prognostic images (generated images) and the follow-up images (real images) was evaluated by zero-mean normalized cross-correlation (ZNCC), peak signal-to-noise ratio (PSNR), and structural similarity (SSIM). Visual assessment was also performed using a numerical rating scale. Prognostic chest CT images were generated using the diffusion model. Image similarity showed reasonable values of 0.973 ± 0.028 for the ZNCC, 24.48 ± 3.46 for the PSNR, and 0.844 ± 0.075 for the SSIM. Visual evaluation of the images by two pulmonologists and one radiologist yielded a reasonable mean score. The similarity and validity of generated predictive images for the course of COVID-19-associated pneumonia using a diffusion model were reasonable. The generation of prognostic images may suggest potential utility for early prediction of the clinical course in COVID-19-associated pneumonia and other respiratory diseases.
Author	Matsuura, Yukiko Okamoto, Takayuki Haneishi, Hideaki Takiguchi, Yasuo Nagayoshi, Masaru Iwao, Yuma Higashide, Takashi Suzuki, Takuji Kawata, Naoko Sekiguchi, Yuki
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Keywords	COVID-19 Deep learning Chest CT images Prognostic image generation Latent diffusion model
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Snippet	Purpose Despite a global decrease in the number of COVID-19 patients, early prediction of the clinical course for optimal patient care remains challenging.... Despite a global decrease in the number of COVID-19 patients, early prediction of the clinical course for optimal patient care remains challenging. Recently,... PurposeDespite a global decrease in the number of COVID-19 patients, early prediction of the clinical course for optimal patient care remains challenging....
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SubjectTerms	Adult Aged Chest Coders Computed tomography COVID-19 COVID-19 - diagnostic imaging Cross correlation Diffusion Diffusion models Female Follow-Up Studies Humans Image processing Imaging Lung - diagnostic imaging Male Medical imaging Medicine Medicine & Public Health Middle Aged Nuclear Medicine Original Original Article Parameters Patients Pneumonia Radiographic Image Interpretation, Computer-Assisted - methods Radiography, Thoracic - methods Radiology Radiomics Radiotherapy Respiratory diseases Retrospective Studies SARS-CoV-2 Signal to noise ratio Similarity Tomography, X-Ray Computed - methods Training
Title	Generation of short-term follow-up chest CT images using a latent diffusion model in COVID-19
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