N-glycans and metastasis in galectin-3 transgenic mice

Poly-N-acetyl-lactosamine (polyLacNAc) on N-glycans facilitate lung specific metastasis of melanoma cells by serving as high affinity ligands for galectin-3, expressed in highest amounts in the lungs, on almost all its tissue compartments including on the surface of vascular endothelium. PolyLacNAc...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 460; no. 2; pp. 302 - 307
Main Authors:	More, Shyam K., Srinivasan, Nithya, Budnar, Srikanth, Bane, Sanjay M., Upadhya, Archana, Thorat, Rahul A., Ingle, Arvind D., Chiplunkar, Shubhada V., Kalraiya, Rajiv D.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.05.2015
Subjects:	Animals Base Sequence bone marrow carbohydrate binding Cell Line, Tumor chimerism DNA Primers endothelium Galectin 3 - genetics Galectin 3 - physiology Galectin-3 Galectin-3 transgenic mice immunity lactose lectins ligands Lung Neoplasms - secondary lungs melanoma Melanoma, Experimental - pathology metastasis Mice Mice, Transgenic Neoplasm Metastasis Organ specific metastasis Polymerase Chain Reaction Polysaccharides - physiology swainsonine transgenic animals Galectin-3 transgenic mice Organ specific metastasis Galectin-3
ISSN:	0006-291X, 1090-2104, 1090-2104
Online Access:	Get full text
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