Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions

Lecithin-based nanoemulsions are colloidal drug delivery systems which offer fundamental advantages in topical therapy, such as excellent skin permeation of lipophilic drugs; however, their physicochemical long-term stability is usually rather poor without the use of additional synthetic surfactants...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 393; no. 1; pp. 153 - 161
Main Authors:	Klang, Victoria, Matsko, Nadejda, Zimmermann, Anna-Maria, Vojnikovic, Emina, Valenta, Claudia
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 30.06.2010 Elsevier
Subjects:	alpha-Cyclodextrins - pharmacology Animals beta-Cyclodextrins - pharmacology Biological and medical sciences Calorimetry, Differential Scanning Chemistry, Pharmaceutical Cryoelectron Microscopy Cyclodextrin Cyclodextrins - chemistry Cyclodextrins - pharmacology Drug Compounding Drug Stability Emulsions Excipients - chemistry Excipients - pharmacology gamma-Cyclodextrins - pharmacology General pharmacology Medical sciences Microscopy, Electron, Transmission Nanoemulsion Nanoparticles Permeability Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Progesterone Progesterone - chemistry Progesterone - metabolism Skin - drug effects Skin - metabolism Skin Absorption - drug effects Sphingosine - analogs & derivatives Sphingosine - chemistry Submicron emulsion Sucrose - analogs & derivatives Sucrose - chemistry Sucrose - pharmacology Sucrose stearate Surface Properties Swine Technology, Pharmaceutical - methods Time Factors Submicron emulsion Cyclodextrin Progesterone Nanoemulsion Sucrose stearate Stability Pharmaceutical technology Sucrose Permeation Stearate Progestagen Emulsion Oside polymer Skin Inclusion compound Sex steroid hormone Physicochemical properties
ISSN:	0378-5173, 1873-3476, 1873-3476
Online Access:	Get full text
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