Development of metastatic HER2+ breast cancer is independent of the adaptive immune system

The tumour‐modulating effects of the endogenous adaptive immune system are rather paradoxical. Whereas some clinical and experimental observations offer compelling evidence for the existence of immunosurveillance, other studies have revealed promoting effects of the adaptive immune system on primary...

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Bibliographic Details
Published in:	The Journal of pathology Vol. 224; no. 1; pp. 56 - 66
Main Authors:	Ciampricotti, Metamia, Vrijland, Kim, Hau, Cheei-Sing, Pemovska, Tea, Doornebal, Chris W, Speksnijder, Ewoud N, Wartha, Katharina, Jonkers, Jos, de Visser, Karin E
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01.05.2011 Wiley
Subjects:	adaptive immune system Adaptive Immunity - immunology Animal models Animals Biological and medical sciences Breast cancer Carcinogenesis Cell Transformation, Neoplastic - immunology ErbB-2 protein Female Gynecology. Andrology. Obstetrics Her2/neu Humans Hyperplasia Immune system Immune Tolerance - immunology Immunologic Surveillance - immunology Immunosurveillance innate immune system Investigative techniques, diagnostic techniques (general aspects) Lung Lung Neoplasms - immunology Lung Neoplasms - secondary Lymphocyte Subsets - immunology Lymphocytes B Mammary gland diseases Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - metabolism Medical sciences Metastases metastasis Mice Mice, Transgenic Neoplasm Transplantation Oncogenes Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptor, ErbB-2 - metabolism Tumor Microenvironment - immunology Tumorigenesis Tumors Breast disease Her2/neu erbB2 Gene Natural immunity Breast cancer Malignant tumor Metastasis adaptive immune system immunosurveillance innate immune system Mammary gland diseases Immunological surveillance Anatomic pathology Development Advanced stage Metastatic Cancer Immune system
ISSN:	0022-3417, 1096-9896, 1096-9896
Online Access:	Get full text
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