Confirmation of ProMisE: A simple, genomics‐based clinical classifier for endometrial cancer

BACKGROUND Classification of endometrial carcinomas (ECs) by morphologic features is irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE), a molecular classification system based on The Cancer Genome Atl...

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Bibliographic Details
Published in:	Cancer Vol. 123; no. 5; pp. 802 - 813
Main Authors:	Talhouk, Aline, McConechy, Melissa K., Leung, Samuel, Yang, Winnie, Lum, Amy, Senz, Janine, Boyd, Niki, Pike, Judith, Anglesio, Michael, Kwon, Janice S., Karnezis, Anthony N., Huntsman, David G., Gilks, C. Blake, McAlpine, Jessica N.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.03.2017
Subjects:	Adult Aged Biomarkers, Tumor - genetics Cancer Carcinoma Classification Classifiers Clinical trials Colorectal cancer Disease-Free Survival DNA Mismatch Repair - genetics DNA Polymerase II - genetics Endometrial cancer endometrial carcinoma Endometrial Neoplasms - classification Endometrial Neoplasms - genetics Endometrial Neoplasms - pathology Endometrium Exonuclease Feasibility studies Female Genetic disorders Genomes Genomics Health risks histotype Humans Immunohistochemistry Medical prognosis Medical research Microsatellite Instability Mismatch repair Missense mutation Mutation Mutation, Missense Neoplasm Staging Oncology p53 p53 Protein Pathology, Molecular Poly-ADP-Ribose Binding Proteins polymerase‐ɛ (POLE) Prognosis prognostic Proteins Risk analysis Risk Factors Risk groups Risk management risk‐stratification system Subgroups Survival The Cancer Genome Atlas (TCGA) Tumor Suppressor Protein p53 - genetics Tumors Uterine cancer prognostic polymerase-ɛ (POLE) risk-stratification system mismatch repair endometrial carcinoma The Cancer Genome Atlas (TCGA) histotype p53
ISSN:	0008-543X, 1097-0142
Online Access:	Get full text
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