Stroma in normal and cancer wound healing

It is currently believed that stroma, the connective framework of biological tissues, plays a central role in normal wound healing and in cancer. In both these contexts, stromal cellular components such as activated fibroblasts interact with complex protein networks that include growth factors, stru...

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Veröffentlicht in:The FEBS journal Jg. 286; H. 15; S. 2909 - 2920
Hauptverfasser: Huet, Eric, Jaroz, Camille, Nguyen, Hoang Quy, Belkacemi, Yazid, Taille, Alexandre, Stavrinides, Vasilis, Whitaker, Hayley
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Blackwell Publishing Ltd 01.08.2019
Schlagworte:
Animals
Cancer
cancer‐associated fibroblasts
Cell proliferation
Cellular communication
Connective Tissue - metabolism
Connective Tissue - pathology
Connective Tissue - radiation effects
Crosstalk
EMMPRIN
Extracellular Matrix Proteins - genetics
Extracellular Matrix Proteins - metabolism
FAPα
Fibroblasts
fibrosis
Growth factors
Humans
Metastases
metastasis
myofibroblasts
neoplasm cells
neoplasms
Neoplasms - metabolism
Neoplasms - radiotherapy
proteinases
Proteins
Radiation Injuries - etiology
Radiation Injuries - metabolism
Radiation therapy
radiotherapy
Radiotherapy - adverse effects
Signal Transduction
structural proteins
TGFβ
Therapeutic applications
tissue repair
Tissues
tumour microenvironment
Wound Healing
cancer-associated fibroblasts
fibroblasts
wound healing
TGFβ
radiotherapy
EMMPRIN
fibrosis
tumour microenvironment
FAPα
myofibroblasts
ISSN:1742-464X, 1742-4658, 1742-4658
Online-Zugang:Volltext
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Zusammenfassung:It is currently believed that stroma, the connective framework of biological tissues, plays a central role in normal wound healing and in cancer. In both these contexts, stromal cellular components such as activated fibroblasts interact with complex protein networks that include growth factors, structural protein or proteinases in order to initiate and sustain an extensive remodelling process. However, although this process is usually spatially and temporally self‐limited, it is unregulated in the case of cancer and leads to uncontrolled cell proliferation and invasion within tissues, metastasis and therapeutic resistance. In this review, we outline the role of stroma in normal healing, cancer and post radiotherapy, with a particular focus on the crosstalk between normal or cancer cells and fibroblasts. Understanding these mechanisms is particularly important as several stromal components have been proposed as potential therapeutic targets. Stromal modification, a key step in the control of wound healing, tumour progression and radiation‐induced fibrosis, is characterized by the differentiation of quiescent fibroblasts into an activated state, which results in crosstalk among fibroblasts and normal or cancer cells. Understanding these activation mechanisms, which involve extracellular matrix metalloproteinase inducer and transforming growth factor beta, is important because several stromal components are potential therapeutic targets.
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ISSN:1742-464X
1742-4658
1742-4658
DOI:10.1111/febs.14842