Stroma in normal and cancer wound healing

It is currently believed that stroma, the connective framework of biological tissues, plays a central role in normal wound healing and in cancer. In both these contexts, stromal cellular components such as activated fibroblasts interact with complex protein networks that include growth factors, stru...

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Bibliographic Details
Published in:	The FEBS journal Vol. 286; no. 15; pp. 2909 - 2920
Main Authors:	Huet, Eric, Jaroz, Camille, Nguyen, Hoang Quy, Belkacemi, Yazid, Taille, Alexandre, Stavrinides, Vasilis, Whitaker, Hayley
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.08.2019
Subjects:	Animals Cancer cancer‐associated fibroblasts Cell proliferation Cellular communication Connective Tissue - metabolism Connective Tissue - pathology Connective Tissue - radiation effects Crosstalk EMMPRIN Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism FAPα Fibroblasts fibrosis Growth factors Humans Metastases metastasis myofibroblasts neoplasm cells neoplasms Neoplasms - metabolism Neoplasms - radiotherapy proteinases Proteins Radiation Injuries - etiology Radiation Injuries - metabolism Radiation therapy radiotherapy Radiotherapy - adverse effects Signal Transduction structural proteins TGFβ Therapeutic applications tissue repair Tissues tumour microenvironment Wound Healing cancer-associated fibroblasts fibroblasts wound healing TGFβ radiotherapy EMMPRIN fibrosis tumour microenvironment FAPα myofibroblasts
ISSN:	1742-464X, 1742-4658, 1742-4658
Online Access:	Get full text
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