Tau Kinetics in Neurons and the Human Central Nervous System

We developed stable isotope labeling and mass spectrometry approaches to measure the kinetics of multiple isoforms and fragments of tau in the human central nervous system (CNS) and in human induced pluripotent stem cell (iPSC)-derived neurons. Newly synthesized tau is truncated and released from hu...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Jg. 97; H. 6; S. 1284
Hauptverfasser:	Sato, Chihiro, Barthélemy, Nicolas R, Mawuenyega, Kwasi G, Patterson, Bruce W, Gordon, Brian A, Jockel-Balsarotti, Jennifer, Sullivan, Melissa, Crisp, Matthew J, Kasten, Tom, Kirmess, Kristopher M, Kanaan, Nicholas M, Yarasheski, Kevin E, Baker-Nigh, Alaina, Benzinger, Tammie L S, Miller, Timothy M, Karch, Celeste M, Bateman, Randall J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.03.2018
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - metabolism Alzheimer Disease - pathology Amino Acid Sequence Biomarkers - cerebrospinal fluid Brain - metabolism Brain - pathology Cell Line Cells, Cultured Central Nervous System - metabolism Central Nervous System - pathology Female Humans Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Kinetics Male Middle Aged tau Proteins - cerebrospinal fluid tau Proteins - metabolism SILK amyloid Alzheimer’s disease induced pluripotent stem cell stable isotope labeling kinetics production rate tau positron emission tomography human phosphorylation PET isoform
ISSN:	1097-4199, 1097-4199
Online-Zugang:	Weitere Angaben
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