The Aging Navigational System
The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain'...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Jg. 95; H. 5; S. 1019 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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United States
30.08.2017
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| ISSN: | 1097-4199, 1097-4199 |
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| Abstract | The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders. |
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| AbstractList | The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders.The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders. The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders. |
| Author | Wolbers, Thomas Wiener, Jan M Lester, Adam W Barnes, Carol A Moffat, Scott D |
| Author_xml | – sequence: 1 givenname: Adam W surname: Lester fullname: Lester, Adam W organization: Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ 85721, USA; Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85721, USA – sequence: 2 givenname: Scott D surname: Moffat fullname: Moffat, Scott D organization: School of Psychology, Georgia Institute of Technology, Atlanta, GA 30332 USA – sequence: 3 givenname: Jan M surname: Wiener fullname: Wiener, Jan M organization: Department of Psychology, Ageing and Dementia Institute, Bournemouth University, Poole BH12 5BB, UK – sequence: 4 givenname: Carol A surname: Barnes fullname: Barnes, Carol A organization: Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ 85721, USA; Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85721, USA; Departments of Psychology, Neurology, and Neuroscience, University of Arizona, Tucson, AZ 85721, USA – sequence: 5 givenname: Thomas surname: Wolbers fullname: Wolbers, Thomas email: thomas.wolbers@dzne.de organization: German Center for Neurodegenerative Diseases (DZNE), Aging and Cognition Research Group, 39120 Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), 39118 Magdeburg, Germany. Electronic address: thomas.wolbers@dzne.de |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28858613$$D View this record in MEDLINE/PubMed |
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