Long-term follow-up study of clear cell papulosis

Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown. The aim of this study was to review cases of CCP diagnosed at our institution and to investigate thei...

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Published in:Journal of the American Academy of Dermatology Vol. 63; no. 2; pp. 266 - 273
Main Authors: Tseng, Fang-Wen, Kuo, Tseng-Tong, Lu, Pei-Hsuan, Chan, Heng-Leong, Chan, Ming-Jing, Hui, Rosaline Chung-Yee
Format: Journal Article
Language:English
Published: New York, NY Mosby, Inc 01.08.2010
Elsevier
Subjects:
Biological and medical sciences
Carcinoembryonic Antigen - metabolism
Child, Preschool
clear cell papulosis
clear cells of Toker
Dermatology
Disease Progression
extramammary Paget disease
Female
Follow-Up Studies
Humans
Hypopigmentation - metabolism
Hypopigmentation - pathology
Immunohistochemistry
Infant
long-term follow-up
Male
Medical sciences
milk line
Mucin-1 - metabolism
Paget Disease, Extramammary - pathology
Pigmentary diseases of the skin
Remission, Spontaneous
Retrospective Studies
Skin - metabolism
Skin - pathology
Skin Diseases, Papulosquamous - metabolism
Skin Diseases, Papulosquamous - pathology
Staining and Labeling
Time Factors
MPD
CCP
milk line
PAS
clear cells of Toker
long-term follow-up
EMA
clear cell papulosis
EMPD
extramammary Paget disease
CEA
carcinoembryonic antigen
periodic acid–Schiff
mammary Paget disease
epithelial membrane antigen
Skin disease
Pigmentation disorder
Clear cell papulosis
Dermatology
Follow up study
Long term
ISSN:0190-9622, 1097-6787, 1097-6787
Online Access:Get full text
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Summary:Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown. The aim of this study was to review cases of CCP diagnosed at our institution and to investigate their outcome. Nineteen patients given a diagnosis of CCP more than 6 years previously were identified. Their medical records and histopathologic findings were reviewed. With a median follow-up duration of 11.5 years, regression of skin lesions was observed in 85.7% of patients. Persistence of skin lesions 11.5 years after diagnosis was confirmed histopathologically in one case, with a reduction in clear cell density. Retrospective nature of the study is a limitation. No treatment is necessary for CCP because the skin lesions are asymptomatic and most patients experience at least partial regression.
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ISSN:0190-9622
1097-6787
1097-6787
DOI:10.1016/j.jaad.2009.08.056