The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth

Cell polarity is an important feature of many tissues and is often disrupted in cancer; the TNF receptor Grindelwald is now shown to have an important role in coordinating cell polarity and neoplastic growth in a Drosophila model. Linking cell polarity and neoplasia Cell polarity is an important fea...

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Bibliographic Details
Published in:	Nature (London) Vol. 522; no. 7557; pp. 482 - 486
Main Authors:	Andersen, Ditte S., Colombani, Julien, Palmerini, Valentina, Chakrabandhu, Krittalak, Boone, Emilie, Röthlisberger, Michael, Toggweiler, Janine, Basler, Konrad, Mapelli, Marina, Hueber, Anne-Odile, Léopold, Pierre
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.06.2015 Nature Publishing Group
Subjects:	631/80/304 Amino Acid Sequence Animals Apoptosis Apoptosis - genetics Biochemistry, Molecular Biology Cancer Cell Adhesion Molecules Cell Adhesion Molecules - metabolism Cell Division Cell Division - genetics Cell Polarity Cell Polarity - genetics Cell Transformation, Neoplastic Cell Transformation, Neoplastic - genetics Cloning Development Biology Disease Models, Animal Drosophila melanogaster Drosophila melanogaster - cytology Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins Drosophila Proteins - chemistry Drosophila Proteins - deficiency Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Genes Genomics Genotype & phenotype Humanities and Social Sciences Humans Insects JNK Mitogen-Activated Protein Kinases JNK Mitogen-Activated Protein Kinases - metabolism letter Life Sciences Male MAP Kinase Signaling System Matrix Metalloproteinase 1 Matrix Metalloproteinase 1 - metabolism Membrane Proteins Membrane Proteins - chemistry Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data multidisciplinary Neoplasm Invasiveness Neoplasm Invasiveness - genetics Neoplasms Neoplasms - enzymology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Proteins ras Proteins ras Proteins - genetics ras Proteins - metabolism Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor - chemistry Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Science Tumors
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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